Optical tomography for small volume absorbing inclusions

We present the asymptotic expansion of the solution to a diffusion equation with a finite number of absorbing inclusions of small volume. We use the first few terms in this expansion measured at the domain boundary to reconstruct the absorption parameters of the inclusions and certain geometrical characteristics. We demonstrate theoretically and numerically that the number of inclusions, their location and their capacity can be reconstructed in a stable way even from moderately noisy data. The reconstruction of the absorption parameter, which is important in optical tomography to discriminate between healthy and unhealthy tissues, requires us however to have far less noisy data. Since the reconstruction of absorption maps from boundary measurements is an extremely ill posed problem, the method of asymptotic expansions of small volume inclusions provides a useful framework to decide which information can be reconstructed from boundary measurements with a given noise level.

[1]  Edward W. Larsen,et al.  The inverse source problem in radiative transfer , 1975 .

[2]  V. Isakov Uniqueness and stability in multi-dimensional inverse problems , 1993 .

[3]  D K Smith,et al.  Numerical Optimization , 2001, J. Oper. Res. Soc..

[4]  N Ramanujam,et al.  Photon migration through fetal head in utero using continuous wave, near-infrared spectroscopy: development and evaluation of experimental and numerical models. , 2000, Journal of biomedical optics.

[5]  Jin Keun Seo,et al.  An accurate formula for the reconstruction of conductivity inhomogeneities , 2003, Adv. Appl. Math..

[6]  Mourad Choulli,et al.  LETTER TO THE EDITOR: Reconstruction of the coefficients of the stationary transport equation from boundary measurements , 1996 .

[7]  S. Arridge Optical tomography in medical imaging , 1999 .

[8]  A. Ishimura Wave Propagation and Scattering in Random Media , 1978 .

[9]  Yves Capdeboscq,et al.  A general representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction , 2003 .

[10]  A. Nachman,et al.  Reconstructions from boundary measurements , 1988 .

[11]  C. Vogel Computational Methods for Inverse Problems , 1987 .

[12]  Akira Ishimaru,et al.  Wave propagation and scattering in random media , 1997 .

[13]  Yves Capdeboscq,et al.  OPTIMAL ASYMPTOTIC ESTIMATES FOR THE VOLUME OF INTERNAL INHOMOGENEITIES IN TERMS OF MULTIPLE BOUNDARY MEASUREMENTS , 2003 .

[14]  Vadim A. Markel,et al.  Inverse problem in optical diffusion tomography. I. Fourier-Laplace inversion formulas. , 2001, Journal of the Optical Society of America. A, Optics, image science, and vision.

[15]  T. Kehoe Uniqueness and Stability , 1998 .

[16]  A. Klose,et al.  Optical tomography using the time-independent equation of radiative transfer-Part 1: Forward model , 2002 .

[17]  Y. Y. Belov,et al.  Inverse Problems for Partial Differential Equations , 2002 .

[18]  V. Isakov Appendix -- Function Spaces , 2017 .

[19]  D. Gilbarg,et al.  Elliptic Partial Differential Equa-tions of Second Order , 1977 .

[20]  Giovanni Alessandrini,et al.  Singular solutions of elliptic equations and the determination of conductivity by boundary measurements , 1990 .

[21]  H. Ammari,et al.  Boundary integral formulae for the reconstruction of electric and electromagnetic inhomogeneities of small volume , 2003 .

[22]  M. V. Rossum,et al.  Multiple scattering of classical waves: microscopy, mesoscopy, and diffusion , 1998, cond-mat/9804141.

[23]  G. Bal Inverse problems for homogeneous transport equations: II. The multidimensional case , 2000 .

[24]  B. Chance,et al.  Spectroscopy and Imaging with Diffusing Light , 1995 .

[25]  O Dorn,et al.  Scattering and absorption transport sensitivity functions for optical tomography. , 2000, Optics express.

[26]  Vadim A. Markel,et al.  Inverse problem in optical diffusion tomography. II. Role of boundary conditions. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[27]  Alexander D. Klose,et al.  Imaging of Rheumatoid Arthritis in Finger Joints by Sagittal Optical Tomography , 2001 .

[28]  Frank Natterer,et al.  Mathematical methods in image reconstruction , 2001, SIAM monographs on mathematical modeling and computation.

[29]  Robert V. Kohn,et al.  Determining conductivity by boundary measurements , 1984 .

[30]  Oliver Dorn,et al.  A transport-backtransport method for optical tomography , 1998 .

[31]  J. Vesecky,et al.  Wave propagation and scattering. , 1989 .

[32]  Michael Vogelius,et al.  Identification of conductivity imperfections of small diameter by boundary measurements. Continuous , 1998 .

[33]  J. Sylvester,et al.  A global uniqueness theorem for an inverse boundary value problem , 1987 .