AQUEOUS EXTRACT OF LIVER: DEVELOPMENT AND USE IN TREATMENT OF PERNICIOUS ANEMIA

The enthusiasm of the medical profession of the entire world was aroused by the original publication of Minot and Murphy1on the brilliant results obtained by feeding liver in the treatment of pernicious anemia. Time has not lessened this enthusiasm; for one is safe in saying that no therapeutic procedure has ever had such universal reports of a consistently favorable character. The development of this therapeutic agency with an accurate description of its use and its limitations is most impressive and will stand as one of the notable achievements in the annals of modern medicine. Any work on this subject done by others can be nothing more than a supplement to that of these pioneers. We at once became interested in this work and, following the original procedure described, used whole liver with strikingly consistent results. No less consistent, however, was the difficulty encountered in maintaining an adequate amount