The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation

[1]  A. Murphy,et al.  Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. , 2010, Arthritis and rheumatism.

[2]  Y. Chan,et al.  Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. , 2010, Atherosclerosis.

[3]  P. Naccache,et al.  Crystal‐induced neutrophil activation , 2010, Immunology and cell biology.

[4]  R. Terkeltaub Update on gout: new therapeutic strategies and options , 2010, Nature Reviews Rheumatology.

[5]  N. Schlesinger,et al.  Serum Urate During Acute Gout , 2009, The Journal of Rheumatology.

[6]  K. Dresser,et al.  A Role of IgM Antibodies in Monosodium Urate Crystal Formation and Associated Adjuvanticity1 , 2009, The Journal of Immunology.

[7]  B. Rovin,et al.  Uric acid and cardiovascular risk. , 2009, The New England journal of medicine.

[8]  Karan Sharma,et al.  Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. , 2008, Immunity.

[9]  H. Hammad,et al.  Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome , 2008, The Journal of Immunology.

[10]  K. Rock,et al.  Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization , 2008, Nature Immunology.

[11]  Richard A. Flavell,et al.  Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants , 2008, Nature.

[12]  Henk C. Hoogsteden,et al.  Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells , 2008, The Journal of experimental medicine.

[13]  William A. Richardson,et al.  SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout , 2008, Nature Genetics.

[14]  S. Akira,et al.  Identification of a key pathway required for the sterile inflammatory response triggered by dying cells , 2007, Nature Medicine.

[15]  R. Terkeltaub,et al.  Engagement of CD14 Mediates the Inflammatory Potential of Monosodium Urate Crystals1 , 2006, The Journal of Immunology.

[16]  S. Akira,et al.  MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. , 2006, The Journal of clinical investigation.

[17]  F. Martinon,et al.  Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.

[18]  R. Terkeltaub,et al.  Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. , 2005, Arthritis and rheumatism.

[19]  R. Terkeltaub,et al.  TLR2 Signaling in Chondrocytes Drives Calcium Pyrophosphate Dihydrate and Monosodium Urate Crystal-Induced Nitric Oxide Generation1 , 2005, The Journal of Immunology.

[20]  R. Terkeltaub,et al.  Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. , 2004, Arthritis and rheumatism.

[21]  渡辺 励 Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity , 2004 .

[22]  James E. Evans,et al.  Molecular identification of a danger signal that alerts the immune system to dying cells , 2003, Nature.

[23]  T. Nakagawa,et al.  Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. , 2002, Hypertension.

[24]  Hirotaka Matsuo,et al.  Molecular identification of a renal urate–anion exchanger that regulates blood urate levels , 2002, Nature.

[25]  S. Bourgoin,et al.  Crystal‐induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals , 2001, Journal of leukocyte biology.

[26]  D. Haskard,et al.  Pathogenesis of crystal-induced inflammation , 2001, Current rheumatology reports.

[27]  T. H. Steele,et al.  Hyperuricemic nephropathies. , 1999, Nephron.

[28]  C. Smyth,et al.  Gout, Hyperuricemia, and Other Crystal-AsSociated Arthropathies , 1998 .

[29]  S. Bourgoin,et al.  Crystal‐induced neutrophil activation VI. Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  H. Koprowski,et al.  Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  L. Addadi,et al.  Specificity in the recognition of crystals by antibodies , 1994, Journal of molecular recognition : JMR.

[32]  H. Schumacher,et al.  Changes in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. , 1993, Arthritis and rheumatism.

[33]  L. Addadi,et al.  Antibodies against crystals , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  H. Iwata,et al.  Solubility of uric acid and supersaturation of monosodium urate: why is uric acid so highly soluble in urine? , 1989, The Journal of urology.

[35]  H. Schumacher,et al.  Immunoglobulin G coating on crystals and ceramics enhances polymorphonuclear cell superoxide production: correlation with immunoglobulin G adsorbed. , 1989, The Journal of rheumatology.

[36]  R. Terkeltaub,et al.  Plasma Protein Binding by Monosodium Urate Crystals , 1983 .

[37]  S. Abramson,et al.  Activation of the alternative pathway of complement by monosodium urate crystals. , 1983, Clinical immunology and immunopathology.

[38]  P. Calvert,et al.  Studies of urate crystallisation in relation to gout. , 1983, Annals of the rheumatic diseases.

[39]  R. Terkeltaub,et al.  Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis. , 1983, Arthritis and rheumatism.

[40]  A. Emery,et al.  Genes for super-intelligence? , 1981, Journal of medical genetics.

[41]  W. Wilcox,et al.  Studies on the nucleation of monsodium urate at 37°C , 1980 .

[42]  W. Wilcox,et al.  Studies on the nucleation of monosodium urate at 37 degrees c. , 1980, Arthritis and rheumatism.

[43]  D. Mccarty,et al.  Molecular orientation of immunoglobulin G adsorbed to microcrystalline monosodium urate monohydrate. , 1980, The Journal of laboratory and clinical medicine.

[44]  N. Mandel,et al.  The structural basis of crystal-induced membranolysis. , 1976, Arthritis and rheumatism.

[45]  W. Wilcox,et al.  Factors affecting urate solubility in vitro. , 1974, Annals of the rheumatic diseases.

[46]  G. Naff,et al.  Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals. , 1973, The Journal of laboratory and clinical medicine.

[47]  C. Duve,et al.  Functions of lysosomes. , 1966, Annual review of physiology.

[48]  S. Cobb,et al.  Social Class Gradient of Serum Uric Acid Levels in Males , 1963 .