Collagen Analysis at Terahertz Band Using Double-Debye Parameter Extraction and Particle Swarm Optimisation

This paper focuses on the analysis of cultivated collagen samples at the terahertz (THz) band using double debye model parameter extraction. Based on measured electrical and optical parameters, we propose a model to describe such parameters extracted with a global optimisation method, namely, particle swarm optimisation. Comparing the measured data with ones in the open literature, it is evident that using only cultivated collagen is not sufficient to represent the performance of the epidermis layer of the skin tissue at the THz band of interest. The results show that the differences between the measured data and published ones are as high as 14 and 6 for the real and imaginary values of the dielectric constant, respectively. Our proposed double debye model agrees well with the measured data.

[1]  Hung T. Nguyen,et al.  A Dielectric Model of Human Breast Tissue in Terahertz Regime , 2015, IEEE Transactions on Biomedical Engineering.

[2]  Dustin G. Mixon,et al.  Electromagnetic properties of tissue in the optical region , 2007, SPIE BiOS.

[3]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[4]  Akram Alomainy,et al.  Advances in Body-Centric Wireless Communication: Applications and State-of-the-art , 2016 .

[5]  Shenghua Ye,et al.  Far-infrared signature of animal tissues characterized by terahertz time-domain spectroscopy , 2006 .

[6]  E. Pickwell‐MacPherson,et al.  Simulation of Terahertz Pulse Propagation in Biological Systems , 2004 .

[7]  Y. Hao,et al.  Numerical Analysis and Characterization of THz Propagation Channel for Body-Centric Nano-Communications , 2015, IEEE Transactions on Terahertz Science and Technology.

[8]  E. Heilweil,et al.  Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz , 2000 .

[9]  V. Wallace,et al.  In vivo study of human skin using pulsed terahertz radiation , 2004, Physics in medicine and biology.

[10]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[11]  Q. Abbasi,et al.  Terahertz Channel Characterization Inside the Human Skin for Nano-Scale Body-Centric Networks , 2016, IEEE Transactions on Terahertz Science and Technology.

[12]  M. Lindstrom,et al.  A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries , 2007, Physics in medicine and biology.

[13]  Akram Alomainy,et al.  Nano-Communication for Biomedical Applications: A Review on the State-of-the-Art From Physical Layers to Novel Networking Concepts , 2016, IEEE Access.

[14]  R. Pethig Dielectric Properties of Biological Materials: Biophysical and Medical Applications , 1984, IEEE Transactions on Electrical Insulation.

[15]  M. El-Shenawee,et al.  Terahertz spectroscopy for the characterization of excised human breast tissue , 2014, 2014 IEEE MTT-S International Microwave Symposium (IMS2014).

[16]  Akram Alomainy,et al.  Fibroblasts cell number density based human skin characterization at THz for in-body nanonetworks , 2016, Nano Commun. Networks.

[17]  Oleksandr Sushko,et al.  Terahertz dielectric study of bio-molecules using time-domain spectrometry and molecular dynamics simulations , 2014 .

[18]  Yang Hao,et al.  Effects of non-flat interfaces in human skin tissues on the in-vivo Tera-Hertz communication channel , 2016, Nano Commun. Networks.

[19]  J. M. Chamberlain,et al.  The interaction between Terahertz radiation and biological tissue. , 2001, Physics in medicine and biology.

[20]  Yang Hao,et al.  Towards Accurate Dielectric Property Retrieval of Biological Tissues for Blood Glucose Monitoring , 2014, IEEE Transactions on Microwave Theory and Techniques.

[21]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[22]  Peter M. Corridon,et al.  Time-domain terahertz spectroscopy of artificial skin , 2006, SPIE BiOS.

[23]  T. Manabe,et al.  A model for the complex permittivity of water at frequencies below 1 THz , 1991 .

[24]  Bao C. Q. Truong,et al.  The Potential of the Double Debye Parameters to Discriminate Between Basal Cell Carcinoma and Normal Skin , 2015, IEEE Transactions on Terahertz Science and Technology.

[25]  E. Pickwell‐MacPherson,et al.  Terahertz pulsed spectroscopy of freshly excised human breast cancer. , 2009, Optics express.

[26]  Shihua Ma,et al.  The Diagnosis of Human Liver Cancer by using THz Fiber-Scanning Near-Field Imaging , 2013 .

[27]  Hung T. Nguyen,et al.  Debye Parameter Extraction for Characterizing Interaction of Terahertz Radiation With Human Skin Tissue , 2013, IEEE Transactions on Biomedical Engineering.