Moving research on resilience into the 21st century: Theoretical and methodological considerations in examining the biological contributors to resilience

Empirical investigations of resilience over the past 30 years have examined a wide range of psychosocial correlates of, and contributors to, this phenomenon. Thus far, theoretical treatments of resilience have focused almost exclusively on psychosocial levels of analysis to derive explanatory models. However, there have been no formal discussions of either theory or research that have examined the biological contributors to, or correlates of, competent functioning despite the experience of adversity. This paper seeks to fill this gap and sets forth a preliminary theoretical framework and outline of empirical strategies for studying the biological underpinnings of resilience. The initial sections of the paper discuss the particular suitability of a transactional organizational theoretical perspective as a conceptual foundation for including a biological level of analysis within the extant theoretical framework of resilience. Subsequently, other important theoretical considerations for the inclusion of a biological perspective on resilience are discussed, including the avoidance of an approach that would reduce resilience to merely a biological process, the application of the constructs of multifinality and equifinality to a biological perspective on resilience, as well as a general discussion of the potential for utilization of brain imaging and other technologies in the study of resilience. The possible relation between the mechanisms of neural plasticity and resilience are examined in some detail, with specific suggestions concerning research questions needed to examine this association. Sections of the paper discuss the likely relation of several areas of brain and biological functioning with resilience, including emotion, cognition, neuroendocrine and immune functioning, and genetics. The paper concludes with a discussion of the implications of a biological perspective on resilience for preventive interventions.

[1]  D. Cicchetti.  How a child builds a brain: Insights from normality and psychopathology: Child psychology in retrospect and prospect , 2014 .

[2]  C. Chabris,et al.  Neural mechanisms of general fluid intelligence , 2003, Nature Neuroscience.

[3]  T. Robinson,et al.  Brain Plasticity and Behavior , 2003, Annual review of psychology.

[4]  N. Abeles,et al.  Decline in verbal memory performance with advancing age: The role of frontal lobe functioning , 2002, Aging & mental health.

[5]  L. Rowland,et al.  Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder , 2002, Biological Psychiatry.

[6]  J. Warren.  Synaptic Self: How our Brains Become who we Are , 2002 .

[7]  D. Cicchetti,et al.  Diverse patterns of neuroendocrine activity in maltreated children , 2001, Development and Psychopathology.

[8]  M. Gunnar,et al.  Salivary cortisol levels in children adopted from Romanian orphanages , 2001, Development and Psychopathology.

[9]  M. D. Bellis.  Developmental traumatology: the psychobiological development of maltreated children and its implications for research, treatment, and policy. , 2001 .

[10]  N. Jausovec,et al.  Differences in EEG current density related to intelligence. , 2001, Brain research. Cognitive brain research.

[11]  Pat Levitt,et al.  Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse , 2001, Trends in Neurosciences.

[12]  A. Masten.  Ordinary magic. Resilience processes in development. , 2001, The American psychologist.

[13]  B. McEwen,et al.  Effects of adverse experiences for brain structure and function , 2000, Biological Psychiatry.

[14]  R. J. Seitz,et al.  A neural basis for general intelligence. , 2000, Science.

[15]  S. Luthar,et al.  The construct of resilience: a critical evaluation and guidelines for future work. , 2000, Child development.

[16]  Elizabeth Gould,et al.  Stress and hippocampal neurogenesis , 1999, Biological Psychiatry.

[17]  M. Koch,et al.  The neurobiology of startle , 1999, Progress in Neurobiology.

[18]  F. Collins,et al.  Mutational analysis using oligonucleotide microarrays , 1999, Journal of medical genetics.

[19]  M. Johnson.  Cortical plasticity in normal and abnormal cognitive development: Evidence and working hypotheses , 1999, Development and Psychopathology.

[20]  N. Birbaumer,et al.  Spatiotemporal organization of brain dynamics and intelligence: an EEG study in adolescents. , 1999, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[21]  J. Douglas Bremner,et al.  Does stress damage the brain? , 1999, Biological Psychiatry.

[22]  E. Kandel,et al.  Biology and the future of psychoanalysis: a new intellectual framework for psychiatry revisited. , 1999, The American journal of psychiatry.

[23]  A. D. de Crespigny,et al.  Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. , 1999, Archives of general psychiatry.

[24]  Scott D. Gest,et al.  Competence in the context of adversity: Pathways to resilience and maladaptation from childhood to late adolescence , 1999, Development and Psychopathology.

[25]  J. Allen,et al.  Resting frontal electroencephalographic asymmetry in depression: inconsistencies suggest the need to identify mediating factors. , 1998, Psychophysiology.

[26]  K. Peters.  Handbook of Child and Adolescent Psychiatry , 1998 .

[27]  E. Kandel,et al.  A new intellectual framework for psychiatry. , 1998, The American journal of psychiatry.

[28]  S. Paradiso.  The Emotional Brain: The Mysterious Underpinnings of Emotional Life , 1998 .

[29]  M. Gunnar.  Quality of early care and buffering of neuroendocrine stress reactions: potential effects on the developing human brain. , 1998, Preventive medicine.

[30]  N. Fox,et al.  EEG activation in 1-month-old infants of depressed mothers , 1997, Development and Psychopathology.

[31]  F. Bloom,et al.  Child Development and Neuroscience. , 1997, Child development.

[32]  C. Grillon,et al.  Startle modulation in children at risk for anxiety disorders and/or alcoholism. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[33]  J E Richters,et al.  The Hubble hypothesis and the developmentalist's dilemma , 1997, Development and Psychopathology.

[34]  S. Orr,et al.  Physiologic responses to loud tones in israeli veterans of the 1973 yom kippur war , 1997, Biological Psychiatry.

[35]  M. Dawson,et al.  The varying time courses of attentional and affective modulation of the startle eyeblink reflex. , 1996, Psychophysiology.

[36]  R. Parritz,et al.  Behavioral inhibition and stress reactivity: the moderating role of attachment security. , 1996, Child development.

[37]  L. Eisenberg,et al.  The social construction of the human brain. , 1995, The American journal of psychiatry.

[38]  B. McEwen.  Steroid Hormone Actions on the Brain: When Is the Genome Involved? , 1994, Hormones and Behavior.

[39]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[40]  B. McEwen,et al.  Stress and the individual. Mechanisms leading to disease. , 1993, Archives of internal medicine.

[41]  R. Plomin,et al.  Families at risk for psychopathology: Who becomes affected and why? , 1993, Development and Psychopathology.

[42]  T. Field.  Infants of depressed mothers , 1992, Development and Psychopathology.

[43]  Jeffrey B. Henriques,et al.  Left frontal hypoactivation in depression. , 1991, Journal of abnormal psychology.

[44]  M. Bradley,et al.  Emotion, attention, and the startle reflex. , 1990, Psychological review.

[45]  P. Lang,et al.  The startle probe response: a new measure of emotion? , 1988, Journal of abnormal psychology.

[46]  M. Buchsbaum,et al.  Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography , 1988 .

[47]  Timothy D. Johnston,et al.  The persistence of dichotomies in the study of behavioral development , 1987 .

[48]  R. Nowakowski.  Basic concepts of CNS development. , 1987, Child development.

[49]  G. Robertson,et al.  The effect of the cold pressor test on vasopressin secretion in man , 1986, Psychoneuroendocrinology.

[50]  G. Schwartz,et al.  Differential lateralization for positive and negative emotion in the human brain: EEG spectral analysis , 1985, Neuropsychologia.

[51]  N. Fox,et al.  The psychobiology of affective development , 1985 .

[52]  S. Counce.  The Strategy of the Genes , 1958, The Yale Journal of Biology and Medicine.

[53]  M. Vanyukov,et al.  Re-Visiting the Validity of the Construct of Resilience , 2002 .

[54]  F. Gage,et al.  Activity-dependent regulation of neuronal plasticity and self repair. , 2000, Progress in brain research.

[55]  M. Kossut,et al.  [Brain plasticity]. , 2000, Neurologia i neurochirurgia polska.

[56]  M. Vrkljan,et al.  The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis. , 1999, Collegium antropologicum.

[57]  J. Bruer.  The Myth of the First Three Years , 1999 .

[58]  M. Glantz,et al.  Resilience and development: Positive life adaptations. , 1999 .

[59]  C. Watson,et al.  Membrane-initiated steroid actions and the proteins that mediate them. , 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[60]  M. Mascolo,et al.  Keeping the constructor in development: An epigenetic systems approach , 1997 .

[61]  Michael W. O'Boyle,et al.  Sex differences, hemispheric laterality, and associated brain activity in the intellectually gifted , 1995 .

[62]  P. Rakić.  Corticogenesis in human and nonhuman primates. , 1995 .

[63]  W. Singer.  Development and plasticity of cortical processing architectures. , 1995, Science.

[64]  Nathan A. Fox,et al.  The development of emotion regulation : biological and behavioral considerations , 1994 .

[65]  James E. Black,et al.  Induction of brain structure by experience: Substrates for cognitive development. , 1992 .

[66]  R. Hinde.  Developmental Psychology in the Context of Other Behavioral Sciences , 1992 .

[67]  D. Watson,et al.  Negative affectivity: the disposition to experience aversive emotional states. , 1984, Psychological bulletin.

[68]  R. Ader.  Developmental psychoneuroimmunology. , 1983, Developmental psychobiology.

[69]  E. Werner,et al.  Vulnerable, But Invincible , 1982 .

[70]  J. Russell.  Developmental psychology , 1980, Nature.

[71]  B. Debièc.  [Studies on child development]. , 1974, Pediatria polska.

[72]  N. Garmezy.  Vulnerability research and the issue of primary prevention. , 1971, The American journal of orthopsychiatry.

[73]  William A. Hunt,et al.  The startle pattern , 1939 .

[74]  Noah Webster,et al.  Webster's new collegiate dictionary , 1936 .