Neurogenic thoracic outlet syndrome in the overhead and throwing athlete: A narrative review

Thoracic outlet syndrome is an important cause of shoulder pain and dysfunction due to compression of neurovascular structures as they traverse the thoracic outlet. Symptoms are most commonly due to compression of the brachial plexus called neurogenic thoracic outlet syndrome (nTOS). Throwing athletes are at increased risk of nTOS because of a variety of biomechanical factors. However, because nTOS symptoms are often nonspecific, delayed diagnosis is common. Neurogenic thoracic outlet largely remains a diagnosis of exclusion with advanced imaging ruling out vascular involvement and diagnostic injections gaining favor in helping localize sites of compression. Although rehabilitation alone may improve symptoms in some athletes, many require surgical treatment for long‐term relief. This generally entails decompression of the thoracic outlet by some combination of muscle release, brachial plexus neurolysis, and first rib resection. Outcomes tend to be successful in athletes with most achieving resolution of symptoms and return to athletic activity. NTOS is an important cause of shoulder pain and dysfunction in throwing athletes. The history and physical examination should focus on activities that exacerbate symptoms. Treatment of nTOS generally requires surgical intervention and allows throwing athletes to return to sport.

[1]  Christopher D. Joyce,et al.  Performance in Major League Baseball Pitchers After Surgical Treatment of Thoracic Outlet Syndrome , 2021, The Physician and sportsmedicine.

[2]  K. Illig,et al.  The Incidence of Thoracic Outlet Syndrome. , 2020, Annals of vascular surgery.

[3]  Robert W. Thompson,et al.  Thoracic Outlet Syndrome in the Overhead Athlete: Diagnosis and Treatment Recommendations , 2020, Current Reviews in Musculoskeletal Medicine.

[4]  R. Gupta,et al.  Sonographically guided botulinum toxin injections in patients with neurogenic thoracic outlet syndrome: correlation with surgical outcomes , 2019, Skeletal Radiology.

[5]  K. Sakurai,et al.  The Gilliatt-Sumner hand: a diagnostic clue of neurogenic thoracic outlet syndrome. , 2018, QJM : monthly journal of the Association of Physicians.

[6]  B. Povlsen,et al.  Diagnosing Thoracic Outlet Syndrome: Current Approaches and Future Directions , 2018, Diagnostics.

[7]  G. Pearl,et al.  Midterm and long‐term follow‐up in competitive athletes undergoing thoracic outlet decompression for neurogenic thoracic outlet syndrome , 2017, Journal of vascular surgery.

[8]  A. Blum,et al.  Dynamic CT angiography for the diagnosis of patients with thoracic outlet syndrome: Correlation with patient symptoms. , 2017, Journal of cardiovascular computed tomography.

[9]  A. Padaki,et al.  Pectoralis Minor Contracture in Throwing Shoulders of Asymptomatic Adolescent Baseball Players , 2017, Orthopaedic journal of sports medicine.

[10]  S. Konno,et al.  The Prevalence and Characteristics of Thoracic Outlet Syndrome in High School Baseball Players , 2017 .

[11]  R. Sanders,et al.  Pectoralis Minor Syndrome: Subclavicular Brachial Plexus Compression , 2017, Diagnostics.

[12]  H. Smith,et al.  Ultrasonographic Diagnosis of Thoracic Outlet Syndrome Secondary to Brachial Plexus Piercing Variation , 2017, Diagnostics.

[13]  David P. Kuwayama,et al.  Choosing Surgery for Neurogenic TOS: The Roles of Physical Exam, Physical Therapy, and Imaging , 2017, Diagnostics.

[14]  C. G. Vos,et al.  Outcome of Surgical Treatment for Thoracic Outlet Syndrome: Systematic Review and Meta-Analysis. , 2017, Annals of vascular surgery.

[15]  M. Mulholland,et al.  Performance Metrics in Professional Baseball Pitchers before and after Surgical Treatment for Neurogenic Thoracic Outlet Syndrome. , 2017, Annals of vascular surgery.

[16]  D. Altchek,et al.  Exercise-Enhanced, Ultrasound-Guided Anterior Scalene Muscle/Pectoralis Minor Muscle Blocks Can Facilitate the Diagnosis of Neurogenic Thoracic Outlet Syndrome in the High-Performance Overhead Athlete , 2017, The American journal of sports medicine.

[17]  Z. Arányi,et al.  Ultrasonographic Identification of Fibromuscular Bands Associated with Neurogenic Thoracic Outlet Syndrome: The "Wedge-Sickle" Sign. , 2016, Ultrasound in medicine & biology.

[18]  J. Freischlag,et al.  Reporting standards of the Society for Vascular Surgery for thoracic outlet syndrome. , 2016, Journal of vascular surgery.

[19]  Constantine A Raptis,et al.  Imaging of the Patient with Thoracic Outlet Syndrome. , 2016, Radiographics : a review publication of the Radiological Society of North America, Inc.

[20]  M. Armon,et al.  The diagnosis of thoracic outlet syndrome , 2014 .

[21]  J. Freischlag,et al.  Diagnostic accuracy of physician and self-referred patients for thoracic outlet syndrome is excellent. , 2014, Annals of vascular surgery.

[22]  R. Sanders,et al.  Thoracic outlet and pectoralis minor syndromes. , 2014, Seminars in vascular surgery.

[23]  A. Weber,et al.  Relevance of bone anomalies in patients with thoracic outlet syndrome. , 2014, Annals of vascular surgery.

[24]  M. Ferrante,et al.  Electrodiagnostic features of true neurogenic thoracic outlet syndrome , 2014, Muscle & nerve.

[25]  F. Rybicki,et al.  Vascular thoracic outlet syndrome: protocol design and diagnostic value of contrast-enhanced 3D MR angiography and equilibrium phase imaging on 1.5- and 3-T MRI scanners. , 2012, AJR. American journal of roentgenology.

[26]  H. Finlayson,et al.  A Review of Thoracic Outlet Syndrome and the Possible Role of Botulinum Toxin in the Treatment of This Syndrome , 2012, Toxins.

[27]  J. Freischlag,et al.  Impact of anterior scalene lidocaine blocks on predicting surgical success in older patients with neurogenic thoracic outlet syndrome. , 2012, Journal of vascular surgery.

[28]  Neil T. Roach,et al.  The effect of humeral torsion on rotational range of motion in the shoulder and throwing performance , 2012, Journal of anatomy.

[29]  B. M. Sucher,et al.  Thoracic Outlet Syndrome—Postural Type: Ultrasound Imaging of Pectoralis Minor and Brachial Plexus Abnormalities , 2012, PM & R : the journal of injury, function, and rehabilitation.

[30]  Jason T. Lee,et al.  Early results of a highly selective algorithm for surgery on patients with neurogenic thoracic outlet syndrome. , 2011, Journal of vascular surgery.

[31]  H. Finlayson,et al.  Botulinum toxin injection for management of thoracic outlet syndrome: A double-blind, randomized, controlled trial , 2011, PAIN.

[32]  L. Padua,et al.  Brachial plexus and nerves about the shoulder. , 2010, Seminars in musculoskeletal radiology.

[33]  T. Hooper,et al.  Thoracic outlet syndrome: a controversial clinical condition. Part 2: non-surgical and surgical management , 2010, The Journal of manual & manipulative therapy.

[34]  L. Watson,et al.  Thoracic outlet syndrome part 2: conservative management of thoracic outlet. , 2010, Manual therapy.

[35]  Frank Birklein,et al.  Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome , 2010, PAIN.

[36]  R. Sanders,et al.  The forgotten pectoralis minor syndrome: 100 operations for pectoralis minor syndrome alone or accompanied by neurogenic thoracic outlet syndrome. , 2010, Annals of vascular surgery.

[37]  T. Hooper,et al.  Thoracic outlet syndrome: a controversial clinical condition. Part 1: anatomy, and clinical examination/diagnosis , 2010, The Journal of manual & manipulative therapy.

[38]  R. Gupta,et al.  Botulinum toxin injection in neurogenic thoracic outlet syndrome: results and experience using a ultrasound-guided approach , 2010, Skeletal Radiology.

[39]  M. Safran,et al.  Case Reports: Unusual Cause of Shoulder Pain in a Collegiate Baseball Player , 2009, Clinical orthopaedics and related research.

[40]  L. Thain,et al.  Humeral head retroversion in competitive baseball players and its relationship to glenohumeral rotation range of motion. , 2007, The Journal of orthopaedic and sports physical therapy.

[41]  P. Pillastrini,et al.  Conservative treatment of thoracic outlet syndrome. A review of the literature. , 2007, Europa medicophysica.

[42]  A. Cotten,et al.  Imaging assessment of thoracic outlet syndrome. , 2006, Radiographics : a review publication of the Radiological Society of North America, Inc.

[43]  N. Byl,et al.  An evidence-based review of magnetic resonance angiography for diagnosing arterial thoracic outlet syndrome. , 2006, Journal of hand therapy : official journal of the American Society of Hand Therapists.

[44]  Samuel S. Ahn,et al.  Thoracic outlet syndrome: pattern of clinical success after operative decompression. , 2005, Journal of vascular surgery.

[45]  A. Dilley,et al.  In vivo study of nerve movement and mechanosensitivity of the median nerve in whiplash and non-specific arm pain patients , 2005, Pain.

[46]  J. Remy,et al.  Diagnosing thoracic outlet syndrome: contribution of provocative tests, ultrasonography, electrophysiology, and helical computed tomography in 48 patients. , 2001, Joint, bone, spine : revue du rhumatisme.

[47]  G. Moneta,et al.  Long-term functional outcome of neurogenic thoracic outlet syndrome in surgically and conservatively treated patients. , 2001, Journal of vascular surgery.

[48]  S. Jordan,et al.  Diagnosis of Thoracic Outlet Syndrome Using Electrophysiologically Guided Anterior Scalene Blocks , 1998, Annals of Vascular Surgery.

[49]  W. Pearce,et al.  Helical computed tomography of the normal thoracic outlet. , 1997, Journal of vascular surgery.

[50]  K. Lindgren,et al.  Conservative treatment of thoracic outlet syndrome: a 2-year follow-up. , 1997, Archives of physical medicine and rehabilitation.

[51]  S. Mackinnon,et al.  Outcome following conservative management of thoracic outlet syndrome. , 1995, The Journal of hand surgery.

[52]  G. Fleisig,et al.  Kinetics of Baseball Pitching with Implications About Injury Mechanisms , 1995, The American journal of sports medicine.

[53]  A. Reiss,et al.  Syndrome , 1990, Biological Psychiatry.

[54]  J. Quintner A study of upper limb pain and paraesthesiae following neck injury in motor vehicle accidents: assessment of the brachial plexus tension test of Elvey. , 1989, British journal of rheumatology.

[55]  A. Warrens,et al.  Thoracic outlet compression syndrome: the lack of reliability of its clinical assessment. , 1987, Annals of the Royal College of Surgeons of England.

[56]  S. Jordan Differential Diagnosis in Patients with Possible NTOS , 2013 .

[57]  Julie Ann Freischlag A DECADE OF EXCELLENT OUTCOMES AFTER SURGICAL INTERVENTION: 538 PATIENTS WITH THORACIC OUTLET SYNDROME. , 2018, Transactions of the American Clinical and Climatological Association.

[58]  V. López,et al.  [Thoracic outlet syndrome]. , 2016, Medicina.

[59]  M. Thatte,et al.  Mini Series : Brachial Plexus Brachial plexus injury in adults : Diagnosis and surgical treatment strategies , 2013 .

[60]  P. I. Edgelow Chapter 7 – Neurovascular Consequences of Cumulative Trauma Disorders Affecting the Thoracic Outlet: A Patient-Centered Treatment Approach , 2004 .

[61]  J Sällström,et al.  Cervicobrachial disorders in certain occupations, with special reference to compression in the thoracic outlet. , 1984, American journal of industrial medicine.

[62]  Irving S. Wright,et al.  The neurovascular syndrome produced by hyperabduction of the arms , 1945 .