KOMBINATORISCHE SYNTHESE NIEDERMOLEKULARER ORGANISCHER VERBINDUNGEN
暂无分享,去创建一个
Friedhelm Balkenhohl | Christoph-Sweder Eberhard Wilhelm von dem Bussche-Hünnefeld | Annegret Lansky | C. Zechel | Friedhelm Balkenhohl | Christoph von dem Bussche‐Hünnefeld | Annegret Lansky | Christian Zechel | Christian Zechel
[1] T. Gadek,et al. A surprising observation about Mitsunobu reactions in solid phase synthesis , 1994 .
[2] S. P. Fodor,et al. Light-directed, spatially addressable parallel chemical synthesis. , 1991, Science.
[3] K. Kaljuste,et al. Solid phase synthesis of 1,2,3,4-tetrahydro-β-carbolines; implications for combinatorial chemistry , 1995 .
[4] A. Mjalli,et al. A combinatorial method for the solid phase synthesis of α-amino phosphonates and phosphonic acids☆ , 1996 .
[5] J. Fréchet,et al. Bromination and lithiation: two important steps in the functionalization of polystyrene resins , 1976 .
[6] P. Keifer. Influence of Resin Structure, Tether Length, and Solvent upon the High-Resolution (1)H NMR Spectra of Solid-Phase-Synthesis Resins. , 1996, The Journal of organic chemistry.
[7] Xiaodong Cao,et al. Synthesis of Nh-acyl-α-aminoamides on rink resin: Inhibitors of the hematopoietic protein tyrosine phosphatase (HePTP) , 1995 .
[8] The use of insoluble polymer supports in general organic synthesis , 1978 .
[9] D. Kempf,et al. Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores. , 1995, Journal of medicinal chemistry.
[10] Lutz Weber,et al. Optimierung der biologischen Aktivität von kombinatorischen Verbindungsbibliotheken durch einen genetischen Algorithmus , 1995 .
[11] T. Carell,et al. New promise in combinatorial chemistry: synthesis, characterization, and screening of small-molecule libraries in solution. , 1995, Chemistry & biology.
[12] J. Pernerstorfer,et al. Rutheniumkatalysierte Metathese polymergebundener Olefine , 1996 .
[13] B. Karger,et al. Affinity Capillary Electrophoresis−Mass Spectrometry for Screening Combinatorial Libraries , 1996 .
[14] R. Zuckermann,et al. Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones , 1995 .
[15] K. Lam,et al. A new type of synthetic peptide library for identifying ligand-binding activity , 1992, Nature.
[16] Solution-phase synthesis in combinatorial chemistry: Applications in drug discovery , 1996 .
[17] J. Ellman,et al. AN EXPEDIENT AND HIGH-YIELDING METHOD FOR THE SOLID-PHASE SYNTHESIS OF DIVERSE 1,4-BENZODIAZEPINE-2,5-DIONES , 1995 .
[18] David W. Gordon,et al. The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317 , 1995 .
[19] Z. Rankovic,et al. A NOVEL LINKER STRATEGY FOR SOLID-PHASE SYNTHESIS , 1996 .
[20] E. Felder,et al. Solid support synthesis of highly functionalized pyrazoles and isoxazoles; Scaffolds for molecular diversity , 1996 .
[22] Robert W. Armstrong,et al. Molecular Diversity via a Convertible Isocyanide in the Ugi Four-Component Condensation , 1995 .
[23] Paul A. Keifer,et al. High-Resolution 1H NMR in Solid-Phase Organic Synthesis , 1994 .
[24] L. Tietze,et al. Stereoselektive Festphasensynthese von Cyclopentanen und Cyclohexanen durch Mehrkomponenten‐Domino‐Reaktion – Aufbau einer Substanzbibliothek durch kombinatorische Chemie , 1996 .
[25] K. Chapman,et al. Solid phase synthesis of aryl ethers via the mitsunobu reaction , 1995 .
[26] S. Kaldor,et al. Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization / cleavage step , 1996 .
[27] M. Gallop,et al. Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation , 1995 .
[28] Peter G. Schultz,et al. A Structure-Based Library Approach to Kinase Inhibitors , 1996 .
[29] A. W. Dean,et al. A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries , 1996 .
[30] I. Hachiya,et al. Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library , 1996 .
[31] A. W. Czarnik,et al. Combinatorial Organic Synthesis Using Parke-Davis's DIVERSOMER Method , 1996 .
[32] H. M. Geysen,et al. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[33] Birong Zhang,et al. Solid phase synthesis of alkenes using the horner-wadsworth-emmons reaction and monitoring by gel phase 31P NMR , 1995 .
[34] J. Baldwin,et al. Synthesis of a Small Molecule Combinatorial Library Encoded with Molecular Tags , 1995 .
[35] V. Rotello,et al. REVERSIBLE COVALENT ATTACHMENT OF C60 TO A POLYMER SUPPORT , 1994 .
[36] ALL-CIS CYCLOPENTANE SCAFFOLDING FOR COMBINATORIAL SOLID PHASE SYNTHESIS OF SMALL NON-PEPTIDE COMPOUNDS , 1994 .
[37] D. Bergbreiter,et al. Modification of substrate reactivity using soluble polymeric supports , 1995 .
[38] D. Wemmer,et al. Site-specific isotopic labeling of proteins for NMR studies , 1992 .
[39] G. Jung,et al. Organic Chemistry on Solid Supports , 1996 .
[40] M E Hemling,et al. Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. , 1996, Analytical chemistry.
[41] A. Mjalli,et al. Solid phase synthesis of pyrroles derived from a four component condensation , 1996 .
[42] Robert C. Anderson,et al. Analytical Techniques in Combinatorial Chemistry: MAS CH Correlation in Solvent-Swollen Resin , 1995 .
[43] J. A. Turner,et al. Acylation of ester enolates by N-methoxy-N-methylamides: an effective synthesis of .beta.-keto esters , 1989 .
[44] S. Wade,et al. Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[45] P. Wipf,et al. A SOLID PHASE PROTOCOL OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS SUITABLE FOR COMBINATORIAL CHEMISTRY , 1995 .
[46] F. Ledl,et al. Die Maillard‐Reaktion in Lebensmitteln und im menschlichen Körper – neue Ergebnisse zu Chemie, Biochemie und Medizin , 1990 .
[47] B. Buckman,et al. Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones , 1996 .
[48] J. J. Parlow. THE USE OF ANION EXCHANGE RESINS FOR THE SYNTHESIS OF COMBINATORIAL LIBRARIES CONTAINING ARYL AND HETEROARYL ETHERS , 1996 .
[49] Czarnik,et al. Automated synthesis and combinatorial chemistry. , 1995, Current opinion in biotechnology.
[50] R. Houghten,et al. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands. , 1993, Life sciences.
[51] A. W. Czarnik,et al. DIVERSOMERTM technology: Solid phase synthesis, automation, and integration for the generation of chemical diversity , 1994 .
[52] C. Holmes,et al. Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. , 1996, Journal of medicinal chemistry.
[53] J. Bolognese,et al. Sample size determination in combinatorial chemistry. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[54] R. H. Schlessinger,et al. Diastereoselective Diels-Alder reactions of nonracemic 3- and 4-amino furans bound to polystyrene. A comparison of these reactions to their solution state analogues , 1996 .
[55] K. Nicolaou,et al. Radiofrequenz‐verschlüsselte kombinatorische Chemie , 1995 .
[56] J. Boutin,et al. Combinatorial peptide synthesis: statistical evaluation of peptide distribution. , 1996, Trends in pharmacological sciences.
[57] G N Murshudov,et al. The structural basis of sequence-independent peptide binding by OppA protein. , 1994, Science.
[58] George Barany,et al. CLEAR : A NOVEL FAMILY OF HIGHLY CROSS-LINKED POLYMERIC SUPPORTS FOR SOLID-PHASE PEPTIDE SYNTHESIS , 1996 .
[59] Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library. , 1995, Chemistry & biology.
[60] I. Hachiya,et al. Aldol reactions on solid phase. Sc(OTf)3-Catalyzed aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol, β-hydroxy carboxylic acid, and β-hydroxy aldehyde libraries , 1996 .
[61] G. Manecke,et al. Synthese und Halbleitereigenschaften arylsubstituierter Imidazole , 1967 .
[62] N. Schore,et al. A polymer-supported C2-symmetric chiral auxiliary: Preparation of non-racemic 3,5-disubstituted-γ-butyrolactones , 1994 .
[63] M. Lebl,et al. Molecular Diversity and Libraries of Structures: Synthesis and Screening , 1996 .
[64] D C Spellmeyer,et al. Measuring diversity: experimental design of combinatorial libraries for drug discovery. , 1995, Journal of medicinal chemistry.
[65] V. Krchnak,et al. Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry. , 2009, International journal of peptide and protein research.
[66] C. Holmes,et al. REAGENTS FOR COMBINATORIAL ORGANIC SYNTHESIS : DEVELOPMENT OF A NEW O-NITROBENZYL PHOTOLABILE LINKER FOR SOLID PHASE SYNTHESIS , 1995 .
[67] Bing Yan,et al. INFRARED SPECTRUM OF A SINGLE RESIN BEAD FOR REAL-TIME MONITORING OF SOLID-PHASE REACTIONS , 1995 .
[68] D. Hangauer,et al. The design and synthesis of substituted biphenyl libraries. , 1996, Bioorganic & medicinal chemistry.
[69] Sydney Brenner,et al. Synthetic methods for the implementation of encoded combinatorial chemistry , 1993 .
[70] C Kempter,et al. Electrospray mass spectrometry and tandem mass spectrometry of synthetic multicomponent peptide mixtures: determination of composition and purity. , 1994, Analytical biochemistry.
[71] Combinatorial modification of natural products: preparation of unencoded and encoded libraries of Rauwolfia alkaloids. , 1996, Bioorganic & medicinal chemistry.
[72] I. Ugi,et al. The Passerini and Ugi Reactions , 1991 .
[73] E. Tate,et al. Generation and screening of an oligonucleotide-encoded synthetic peptide library. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[74] Roger A. Jones,et al. A universal allyl linker for solid-phase synthesis , 1996 .
[75] D. Gordon,et al. Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library , 1995 .
[76] H. Coste,et al. Orthogonal Combinatorial Chemical Libraries , 1995 .
[77] J. Ellman,et al. A General Solid-Phase Synthesis Strategy for the Preparation of 2-Pyrrolidinemethanol Ligands , 1995 .
[78] N. Schore,et al. POLYMER-SUPPORTED SYNTHESIS OF CYCLIC ETHERS : ELECTROPHILIC CYCLIZATION OF ISOXAZOLINES , 1995 .
[79] S. Teague. Facile synthesis of a o-nitrobenzyl photolabile linker for combinatorial chemistry , 1996 .
[80] E. Corey,et al. The Logic of Chemical Synthesis , 1989 .
[81] E. Bayer. Towards the Chemical Synthesis of Proteins , 1991 .
[82] Jonathan A. Ellman,et al. Straightforward and general method for coupling alcohols to solid supports , 1994 .
[83] M. Bradley,et al. Solid Phase Chemistry: Direct Monitoring by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. A Tool for Combinatorial Chemistry , 1995 .
[84] G. Wei,et al. Solid phase synthesis of benzimidazoles , 1996 .
[85] G A Petsko,et al. Interaction of a peptidomimetic aminimide inhibitor with elastase. , 1995, Science.
[86] Ken D. Shimizu,et al. ENTWICKLUNG VON CHIRALEN KATALYSATOREN DURCH KOMBINATORISCHE LIGANDENVARIATION : TI-KATALYSIERTE ENANTIOSELEKTIVE ADDITION VON TMSCN AN MESO-EPOXIDE , 1996 .
[87] Jeremy Green. Solid Phase Synthesis of Lavendustin A and Analogs , 1995 .
[88] S. Chan,et al. Synthesis and Photolysis Properties of a Photolabile Linker Based on 3‘-Methoxybenzoin† , 1996 .
[89] S. P. Fodor,et al. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. , 1994, Journal of medicinal chemistry.
[90] Yang Lihu,et al. Pictet-Spengler reaction on solid support , 1996 .
[91] Á. Furka,et al. General method for rapid synthesis of multicomponent peptide mixtures. , 2009, International journal of peptide and protein research.
[92] D. Tortolani,et al. A solid phase synthesis of miconazole analogs via an iodoetherification reaction , 1996 .
[93] W. Murray,et al. Solid-Phase Suzuki Coupling for C−C Bond Formation , 1996 .
[94] M. Meldal,et al. POEPOP AND POEPS : INERT POLYETHYLENE GLYCOL CROSSLINKED POLYMERIC SUPPORTS FOR SOLID SYNTHESIS , 1996 .
[95] Xiaodong Cao,et al. Combinatorial method for the synthesis of α-hydroxy phosphonates on Wang resin , 1996 .
[96] S. Torii,et al. Asymmetric multipoint control by palladium-catalyzed diastereoselective tandem carbon-carbon bond formation , 1992 .
[97] Gordon. Libraries of non-polymeric organic molecules. , 1995, Current opinion in biotechnology.
[98] R. Zuckermann,et al. THE SYNTHESIS OF 2-OXOPIPERAZINES BY INTRAMOLECULAR MICHAEL ADDITION ON SOLID SUPPORT , 1996 .
[99] C. Holmes,et al. The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries , 1996 .
[100] D. Boger,et al. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template. , 1996, Bioorganic & medicinal chemistry.
[101] R. Valerio,et al. Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry , 1996 .
[102] S. Larsen,et al. Synthesis and hypocholesterolemic activity of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-diones, novel inhibitors of acylCoA:cholesterol O-acyltransferase. , 1991, Journal of medicinal chemistry.
[103] M. Lebl,et al. Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support , 1993 .
[104] L. A. Randall,et al. "Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis , 1994 .
[105] R. Larock,et al. Organopalladium approaches to prostaglandins. 9. Synthesis of a prostaglandin endoperoxide analogue by allylpalladation-ozonolysis of norbornene , 1988 .
[106] J. Mason,et al. New perspectives in lead generation II: Evaluating molecular diversity , 1996 .
[107] R. W. Armstrong,et al. Synthesis of Tetrasubstituted Ethylenes on Solid Support via Resin Capture , 1996 .
[108] P. Dorff,et al. A solid phase CBZ chloride equivalent — a new matrix specific linker , 1995 .
[109] H. Rink. Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin. , 1987 .
[110] G. Jung,et al. Multiple Peptide Synthesis Methods and Their Applications. New Synthetic Methods (87) , 1992 .
[111] M. Arlt,et al. ARYL-ARYL CROSS COUPLING ON A SOLID SUPPORT USING ZINC ORGANIC REAGENTS AND PALLADIUM CATALYSIS , 1996 .
[112] S. Balasubramanian,et al. Solid phase reductive alkylation of secondary amines , 1996 .
[113] K. Janda,et al. Tagged versus untagged libraries: methods for the generation and screening of combinatorial chemical libraries. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[114] Jonathan A. Ellman,et al. Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner's "Safety-Catch" Linker , 1994 .
[115] Mark A. Gallop,et al. Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library , 1995 .
[116] Raju Mohan,et al. Pictet-Spengler reaction on solid support: Synthesis of 1,2,3,4-tetrahydro-β-carboline libraries , 1996 .
[117] S J Rodda,et al. A priori delineation of a peptide which mimics a discontinuous antigenic determinant. , 1986, Molecular immunology.
[118] L Wang,et al. Peptoids: a modular approach to drug discovery. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[119] M. Fournié-Zaluski,et al. Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. , 1993, Pharmacological reviews.
[120] R. W. Armstrong,et al. Postcondensation Modifications of Ugi Four-Component Condensation Products: 1-Isocyanocyclohexene as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture , 1996 .
[121] J. Sredy,et al. Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents. , 1992, Journal of medicinal chemistry.
[122] D. Siev,et al. Imidazole libraries on solid support , 1996 .
[123] S. Berets,et al. Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry , 1996 .
[124] Peter G. Schultz,et al. A Combinatorial Approach to Materials Discovery , 1995, Science.
[125] C. Holmes,et al. Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring , 1994 .
[126] R A Houghten,et al. Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings , 1994, Biopolymers.
[127] S. Brenner,et al. Recursive deconvolution of combinatorial chemical libraries. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[128] S. Brenner,et al. Liquid-phase combinatorial synthesis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[129] E. Schleicher,et al. New Aspects of the Maillard Reaction in Foods and in the Human Body , 1990 .
[130] G. Jung,et al. Ionenspray‐Massenspektrometrie und Hochleistungsflüssigkeitschromatographie ‐ Massenspektrometrie von synthetischen Peptidbibliotheken , 1993 .
[131] D. Boger,et al. Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules , 1996 .
[132] K. Chapman,et al. Solid phase synthesis of tetrahydroisoquinolines & tetrahydroimidazopyridines , 1996 .
[133] G. Posner. Multicomponent one-pot annulations forming 3 to 6 bonds , 1986 .
[134] M. Deshpande. Formation of carbon-carbon bond on solid support: Application of the stille reaction , 1994 .
[135] F. Zaragoza. Solid-phase synthesis of substituted 3-aminothiophenes and 2-methylene-2,3-dihydrothiazoles , 1996 .
[136] Kevin Burgess,et al. New Catalysts and Conditions for a CH Insertion Reaction Identified by High Throughput Catalyst Screening , 1996 .
[137] F. W. Forman,et al. Solid-Phase Synthesis of Biaryls via the Stille Reaction , 1995 .
[138] G. Chiusoli,et al. One-pot palladium-catalyzed synthesis of 2,3-disubstituted bicyclo[2.2.1]heptanes and bicyclo[2.2.1]hept-5-enes , 1982 .
[139] A. Nickon,et al. A Direct Method for Reductive Deamination of Aliphatic Amines , 1964 .
[140] S. P. Fodor,et al. Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. , 1994, Journal of medicinal chemistry.
[141] J. C. Chabala. Solid-phase combinatorial chemistry and novel tagging methods for identifying leads. , 1995, Current opinion in biotechnology.
[142] Jonathan A. Ellman,et al. SIMULTANEOUS SOLID-PHASE SYNTHESIS OF BETA -TURN MIMETICS INCORPORATING SIDE-CHAIN FUNCTIONALITY , 1994 .
[143] G. Siuzdak,et al. Direct characterization of solid phase resin-bound molecules by mass spectrometry , 1996 .
[144] D A Konings,et al. Deconvolution of combinatorial libraries for drug discovery: a model system. , 1995, Journal of medicinal chemistry.
[145] S. Hanessian,et al. Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity , 1996 .
[146] J. Ellman,et al. Palladium-Mediated Three-Component Coupling Strategy for the Solid-Phase Synthesis of Tropane Derivatives(1). , 1996, The Journal of organic chemistry.
[147] R. Houghten. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[148] W. C. Still,et al. Discovery of Sequence-Selective Peptide Binding by Synthetic Receptors Using Encoded Combinatorial Libraries , 1996 .
[149] D. Ecker,et al. Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[150] E. Gordon,et al. Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines , 1996 .
[151] Robert W. Armstrong,et al. Multiple-Component Condensation Strategies for Combinatorial Library Synthesis , 1996 .
[152] I. Sucholeiki. Solid-phase photochemical C-S bond cleavage of thioethers-a new approach to the solid-phase production of non-peptide molecules , 1994 .
[153] Kevin Burgess,et al. Durch Screening ermittelte Katalysatoren und Reaktionsbedingungen für eine C‐H‐Insertionsreaktion , 1996 .
[154] R. Meloen,et al. Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[155] M. Bradley,et al. A simple multiple release system for combinatorial library and peptide analysis , 1996 .
[156] D. Santi,et al. Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[157] S. Gilbertson,et al. The combinatorial synthesis of chiral phosphine ligands , 1996 .
[158] Barry A. Bunin,et al. A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives , 1992 .
[159] Binäre Codierung von Verbindungsbibliotheken , 1994 .
[160] K. Chapman,et al. A strategy for urea linked diamine libraries , 1995 .
[161] R. B. Merrifield. Solid phase peptide synthesis. I. the synthesis of a tetrapeptide , 1963 .
[162] B. Hamper,et al. Solid-phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition , 1996 .
[163] M. Schroeder,et al. "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[164] Johann Gasteiger,et al. Bewertung der Ähnlichkeit und Vielfalt von Verbindungsbibliotheken mit räumlichen Autokorrelationsfunktionen und neuronalen Netzen , 1995 .
[165] K. Chapman,et al. Fischer indole synthesis on a solid support , 1996 .
[166] M. Wigler,et al. Complex synthetic chemical libraries indexed with molecular tags. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[167] Stephen B. H. Kent,et al. Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis , 1992 .
[168] Robert P. Sheridan,et al. Using a Genetic Algorithm To Suggest Combinatorial Libraries , 1995, J. Chem. Inf. Comput. Sci..
[169] E. Moran,et al. Synthesis of tetrasubstituted imidazoles via α-(N-acyl-N-alkylamino)-β-ketoamides on Wang resin , 1996 .
[170] K. W. Jung,et al. A linker that allows efficient formation of aliphatic CH bonds on polymeric supports , 1996 .
[171] Dinesh V. Patel,et al. Applications of small-molecule combinatorial chemistry to drug discovery , 1996 .
[172] D. Rice,et al. A Comparison of NMR Spectra Obtained for Solid-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes , 1996 .
[173] M. Lyttle. Combinatorial chemistry: A conservative perspective , 1995 .
[175] B. Hamper,et al. Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones , 1996 .
[176] T. Keough,et al. Matrix-assisted laser desorption ionization for rapid determination of the sequences of biologically active peptides isolated from support-bound combinatorial peptide libraries. , 1994, Rapid communications in mass spectrometry : RCM.
[177] R. Frank. Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support , 1992 .
[178] J. Mayer,et al. Application of the Pictet-Spengler reaction in combinatorial chemistry , 1996 .
[179] Robert D Clark,et al. Neighborhood behavior: a useful concept for validation of "molecular diversity" descriptors. , 1996, Journal of medicinal chemistry.
[180] R. W. Armstrong,et al. Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B , 1995 .
[181] K. Shimizu,et al. Discovery of Chiral Catalysts through Ligand Diversity: Ti‐Catalyzed Enantioselective Addition of TMSCN to meso Epoxides , 1996 .
[182] R. Zuckermann,et al. Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures , 1995 .
[183] B. Karger,et al. Free Solution Identification of Candidate Peptides from Combinatorial Libraries by Affinity Capillary Electrophoresis/Mass Spectrometry , 1995 .
[184] Harry C. J. Ottenheijm,et al. Solid-phase organic reactions: A review of the recent literature , 1996 .
[185] M. Deshpande,et al. Heck reactions in solid phase synthesis , 1994 .
[186] Gnther Jung,et al. Combinatorial Peptide and Nonpeptide Libraries , 1996 .
[187] M. Lebl,et al. Polymer-Supported Mitsunobu Ether Formation and its Use in Combinatorial Chemistry , 1995 .
[188] Paul W. Finn,et al. Computer-based screening of compound databases for the identification of novel leads , 1996 .
[189] E. Bayer. Auf dem Weg zur chemischen Synthese von Proteinen , 1991 .
[190] R. Tanner,et al. Peptide synthesis by a combination of solid-phase and solution methods. I: A new very acid-labile anchor group for the solid phase synthesis of fully protected fragments , 1988 .
[191] Synthesis of ketones and aldehydes via reactions of Weinreb-type amides on solid support , 1996 .
[192] M. J. Gardner,et al. COMBINATORIAL SYNTHESIS : THE DESIGN OF COMPOUND LIBRARIES AND THEIR APPLICATION TO DRUG DISCOVERY , 1995 .
[193] Á. Furka. History of combinatorial chemistry , 1995 .
[194] D. Boger,et al. Generalized Dipeptidomimetic Template: Solution Phase Parallel Synthesis of Combinatorial Libraries , 1996 .
[195] R. Houghten,et al. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery , 1991, Nature.
[196] K. Nicolaou,et al. Radiofrequency Encoded Combinatorial Chemistry , 1995 .
[197] M. Lebl,et al. Solid-phase synthesis of “small” organic molecules based on thiazolidine scaffold , 1995 .
[198] N. Sigal,et al. A paradigm for drug discovery employing encoded combinatorial libraries. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[199] B. Yan,et al. Probing solid-phase reactions by monitoring the IR bands of compounds on a single “flattened” resin bead , 1996 .
[200] K. Kaljuste,et al. Solid-phase synthesis of peptide aminoalkylamides using an allyl linker , 1996 .
[201] F. Albericio,et al. Three-dimensional orthogonal protection scheme for solid-phase peptide synthesis under mild conditions , 1985 .
[202] T. Carell,et al. Characterization of the complexity of small-molecule libraries of electrospray ionization mass spectrometry. , 1995, Analytical chemistry.
[203] Jonathan A. Ellman,et al. Design, Synthesis, and Evaluation of Small-Molecule Libraries , 1996 .
[204] Matthew J. Plunkett,et al. A Silicon-Based Linker for Traceless Solid-Phase Synthesis , 1995 .
[205] M. Pirrung,et al. PREPARATION AND SCREENING AGAINST ACETYLCHOLINESTERASE OF A NON-PEPTIDE INDEXED COMBINATORIAL LIBRARY , 1995 .
[206] D. Cole,et al. Analytical Techniques for Combinatorial Chemistry: Quantitative Infrared Spectroscopic Measurements of Deuterium-Labeled Protecting Groups , 1996 .
[207] J. Ellman,et al. Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries. , 1995, Journal of medicinal chemistry.
[208] J. Krstenansky,et al. Solid phase synthesis of aryl and benzylpiperazines and their application in combinatorial chemistry , 1995 .
[209] R. W. Armstrong,et al. Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: Synthesis of α-acylaminoesters and pyrroles , 1996 .
[210] I. Ugi,et al. Multicomponent reactions in organic chemistry , 1994 .
[211] Edward P. Jaeger,et al. Application of Genetic Algorithms to Combinatorial Synthesis: A Computational Approach to Lead Identification and Lead Optimization†,∇ , 1996 .
[212] Ryoji Noyori,et al. Three-component coupling synthesis of prostaglandins. A simplified, general procedure , 1990 .
[213] R. Friesen,et al. Biaryl synthesis via suzuki coupling on a solid support , 1994 .
[214] H. Künzer,et al. Structurally diverse 2,6-disubstituted quinoline derivatives by solid-phase synthesis , 1996 .
[215] R. Valerio,et al. Grafted supports used with the multipin method of peptide synthesis , 1994 .
[216] K. Chapman,et al. A general method for the solid phase synthesis of ureas , 1994 .
[217] M. Cushman,et al. A study and mechanistic interpretation of the electronic and steric effects that determine the stereochemical outcome of the reaction of Schiff bases with homophthalic anhydride and 3-phenylsuccinic anhydride , 1987 .
[218] Jonathan A. Ellman,et al. Synthesis and Applications of Small Molecule Libraries. , 1996, Chemical reviews.
[219] L. Tietze,et al. Stereoselective Solid-Phase Synthesis of Cyclopentane and Cyclohexane Derivatives by Two-Component Domino Reactions: Generation of Combinatorial Libraries†‡ , 1996 .
[220] R. Larock,et al. Organopalladium approaches to prostaglandins. 4. Synthesis of the first interphenylene PGH2 analogs via benzylpalladation , 1985 .
[221] I. Ugi,et al. Isonitrile, II. Reaktion von Isonitrilen mit Carbonylverbindungen, Aminen und Stickstoffwasserstoffsäure , 1961 .
[222] C. Holmes,et al. Strategies for Combinatorial Organic Synthesis: Solution and Polymer-Supported Synthesis of 4-Thiazolidinones and 4-Metathiazanones Derived from Amino Acids , 1995 .
[223] N. Schore,et al. Polymer-supported synthesis of 2,5-disubstituted tetrahydrofurans , 1992 .
[224] S M Freier,et al. Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies. , 1996, Journal of medicinal chemistry.
[225] G. Jung,et al. Organische Chemie an fester Phase , 1996 .
[226] R. Petter,et al. 19F NMR monitoring of a SNAr reaction on solid support , 1996 .
[227] Dinesh V. Patel,et al. Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery , 1996 .
[228] L. A. Randall,et al. Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy , 1994 .
[229] W. Bannwarth,et al. A new linker for primary amines applicable to combinatorial approaches , 1996 .
[230] G. Whitesides,et al. Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry. , 1996, Journal of medicinal chemistry.
[231] R. Lerner,et al. Encoded combinatorial chemistry. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[232] Klaus Gubernator,et al. Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm , 1995 .
[233] J. Fauchère,et al. Combinatorial peptide libraries: robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques. , 1996, Analytical Biochemistry.
[234] I. Ugi,et al. Beyond peptide and nucleic acid combinatorial libraries-applying unions of multicomponent reactions towards the generation of carbohydrate combinatorial libraries , 1995 .
[235] Matthew J. Plunkett,et al. Solid-Phase Synthesis of Structurally Diverse 1,4-Benzodiazepine Derivatives Using the Stille Coupling Reaction , 1995 .
[236] Thomas Carell,et al. Screeningverfahren in Lösung zur Isolierung biologisch aktiver Verbindungen aus einer Molekülbibliothek , 1994 .
[237] B. J. Backes,et al. Activation Method to Prepare a Highly Reactive Acylsulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis1 , 1996 .
[238] R. W. Armstrong,et al. Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation , 1996 .
[239] P. Griffin,et al. Microchemical structural determination of a peptoid covalently bound to a polymeric bead by matrix-assisted laser desorption ionization time-of-flight mass spectrometry , 1994 .
[240] R. Zuckermann,et al. Encoded combinatorial peptide libraries containing non-natural amino acids , 1993 .
[241] S. D. Brown,et al. Parallele Festphasensynthesen durch Ugi‐Mehrkomponentenkondensation , 1996 .
[242] R. Cortese. Combinatorial libraries : synthesis, screening and application potential , 1996 .
[243] P. Leeson,et al. An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis , 1996 .
[244] H. Nestler,et al. Microautoradiographic identification of receptor-ligand interactions in bead-supported combinatorial libraries , 1996 .
[245] Thomas Rawson,et al. From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold , 1994 .
[246] S. Benkovic,et al. A mass spectrometric solution to the address problem of combinatorial libraries. , 1994, Science.
[247] P. Zhou,et al. Formation of CC bond in solid phase synthesis using the heck reaction , 1995 .
[248] G. Chiusoli,et al. Palladium- or nickel-catalyzed sequential reaction of organic bromides, bicyclo[2.2.1]hept-2-ene or bicyclo[2.2.1]hepta-2,5-diene and alkynes , 1984 .
[249] G. Breipohl,et al. Solid phase synthesis of peptide aminoalkylamides development and application of new linking agents , 1987 .
[250] J. Vilarrasa,et al. A fast procedure for the reduction of azides and nitro compounds based on the reducing ability of Sn(SR)3-species , 1990 .
[251] S. Rahman,et al. COMBINATORIAL CHEMISTRY : DIRECT ANALYSIS OF BEAD SURFACE ASSOCIATED MATERIALS , 1995 .
[252] E. Gordon,et al. APPROACHES TO COMBINATORIAL SYNTHESIS OF HETEROCYCLES : A SOLID-PHASE SYNTHESIS OF 1,4-DIHYDROPYRIDINES , 1996 .
[253] J. Westman,et al. Magic angle spinning NMR: A valuable tool for monitoring the progress of reactions in solid phase synthesis , 1996 .
[254] N. Schore,et al. Pauson-Khand cycloadditions of polymer-linked substrates , 1990 .
[255] P. Schultz. Lessons from the Immune System: From Catalysis to Materials , 1996 .
[256] S. S. Wang. p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments. , 1973, Journal of the American Chemical Society.
[257] Johann Gasteiger,et al. Assessing Similarity and Diversity of Combinatorial Libraries by Spatial Autocorrelation Functions and Neural Networks , 1996 .
[258] G. Jung,et al. Methoden der multiplen Peptidsynthese und ihre Anwendungen , 1992 .
[259] P. Schultz,et al. A Class of Cobalt Oxide Magnetoresistance Materials Discovered with Combinatorial Synthesis , 1995, Science.
[260] E. Gordon,et al. Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams , 1996 .
[261] P. Willett. Genetic algorithms in molecular recognition and design. , 1995, Trends in biotechnology.
[262] W. C. Still,et al. A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries , 1994 .
[263] Susanta K. Sarkar,et al. An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications , 1996 .
[264] The solid phase synthesis of dihydro- and tetrahydroisoquinolines , 1995 .
[265] F. Sebestyén,et al. Chemical synthesis of peptide libraries , 1993 .
[266] V. Gnau,et al. Ion‐Spray Mass Spectrometry and High‐Performance Liquid Chromatography—Mass Spectrometry of Synthetic Peptide Libraries , 1993 .
[267] K. Burgess,et al. Combinatorial technologies involving reiterative division/coupling/recombination: statistical considerations. , 1994, Journal of medicinal chemistry.
[268] N K Terrett,et al. Parallel-compound synthesis: methodology for accelerating drug discovery. , 1996, Bioorganic & medicinal chemistry.
[269] J. Rebek,et al. Solution-phase generation of tetraurea libraries. , 1996, Bioorganic & medicinal chemistry.
[270] Barry A. Bunin,et al. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[271] J. Adams,et al. Use of Spin Echo Magic Angle Spinning 1H NMR in Reaction Monitoring in Combinatorial Organic Synthesis , 1996 .
[272] M. Mutter,et al. Liquid Phase Synthesis of Peptides , 1972, Nature.
[273] Carl R. Johnson,et al. A two-step, three-component synthesis of PGE1: utilization of .alpha.-iodo enones in Pd(0)-catalyzed cross-couplings of organoboranes , 1993 .
[274] Thomas Carell,et al. Neuartiges Verfahren zur Herstellung von Bibliotheken kleiner organischer Moleküle , 1994 .
[275] J. Fréchet. Tetrahedron report number 103 , 1981 .