Effect of fish oil on blood pressure and blood lipids in men with mild to moderate hypertension.

Forty men with mild to moderate hypertension were given one of two dietary supplements for 6 weeks: 20 capsules of fish oil (MaxEPA) or placebo (olive and corn oil). The MaxEPA supplement provided about 7 g omega-3-fatty acids pr day, whereas the placebo contained about 7 g omega-6-fatty acids and only 0.2 g omega-3-fatty acids. A clinical insignificant reduction in blood pressure was noted in both groups. In the fish oil group, the serum triglyceride levels fell by 30%. A decrease in the ratio total cholesterol/high density lipoprotein (HDL-) cholesterol was noted in both groups, most pronounced in the placebo group. No significant effect on total serum cholesterol level was observed during this study.

[1]  J. Dyerberg,et al.  The composition of food consumed by Greenland Eskimos. , 2009, Acta medica Scandinavica.

[2]  K. Bønaa,et al.  [Can oil be used as an antihypertensive agent?]. , 1987, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[3]  B. Butland,et al.  Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, haemostatic and rheological variables. A double blind randomised controlled trial in healthy volunteers. , 1987, Atherosclerosis.

[4]  C. Taube,et al.  Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. , 1986, Atherosclerosis.

[5]  F. Cambien,et al.  Is the level of serum triglyceride a significant predictor of coronary death in "normocholesterolemic" subjects? The Paris Prospective Study. , 1986, American journal of epidemiology.

[6]  W. Castelli,et al.  The triglyceride issue: a view from Framingham. , 1986, American heart journal.

[7]  C. J. Jones,et al.  Opiate withdrawal: inpatient versus outpatient programmes and preferred versus random assignment to treatment. , 1986, British medical journal.

[8]  L. Wilkins Nonpharmacological approaches to the control of high blood pressure. Final report of the Subcommittee on Nonpharmacological Therapy of the 1984 Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. , 1986, Hypertension.

[9]  J. Kinsella,et al.  Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. , 1986, The American journal of clinical nutrition.

[10]  W. Harris,et al.  Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia , 1985 .

[11]  T. Sanders,et al.  A comparison of the influence on plasma lipids and platelet function of supplements of ω3 and ω6 polyunsaturated fatty acids , 1983, British Journal of Nutrition.

[12]  E. Schmidt,et al.  The Effect of N-6 and N-3 Polyunsaturated Fatty Acids on Hemostasis, Blood Lipids and Blood Pressure , 1983, Thrombosis and Haemostasis.

[13]  P. Weber,et al.  Platelet Function, Thromboxane Formation and Blood Pressure Control During Supplementation of the Western Diet with Cod Liver Oil , 1983, Circulation.

[14]  E. Vartiainen,et al.  CONTROLLED, RANDOMISED TRIAL OF THE EFFECT OF DIETARY FAT ON BLOOD PRESSURE , 1983, The Lancet.

[15]  M. Lopes-Virella,et al.  Cholesterol determination in high-density lipoproteins separated by three different methods. , 1977, Clinical chemistry.

[16]  E. Glasgow,et al.  Quartan malarial nephrotic syndrome. Collaborative clinicopathological study in Nigerian children. , 1972, Lancet.

[17]  J. Dyerberg,et al.  Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. , 1971, Lancet.

[18]  D. Allen,et al.  Clinical studies on the effect of dietary n − 6 and n − 6 fatty acids on serum lipids, haemostasis and GTN consumption , 1986 .

[19]  A. Wahlefeld Triglycerides Determination after Enzymatic Hydrolysis , 1974 .