Occurrence of Scopulariopsis and Scedosporium in nails and keratinous skin. A 5-year retrospective multi-center study.

A 5-year retrospective multicenter study was performed for microascaceous moulds (Microascaceae, Ascomycetes) in Finnish clinical specimens. The files from 1993-1997 of six clinical mycology laboratories in Finland were searched for reports of these fungi, mainly Scopulariopsis and Scedosporium anamorphs in keratinous specimens. From the 521 primary findings, 165 cases were selected for further study based on direct microscopy, colony numbers and accompanying fungi. The clinical records of 148 cases (141 Scopulariopsis, 7 Scedosporium) were studied. Of the nail infections from which Scopulariopsis was recovered, 39 cases were further separated which showed clinical or laboratory-based evidence of dermatophytosis. In the remaining 90 'non-dermatophyte' nail cases, Scopulariopsis spp. were the only documented fungal agents (c. 6 cases/million/year). The patients were mainly elderly, 66% of whom had problems involving their big toe nails. For 74% of them, the nail problem was mentioned as their reason for visiting the physician. However, only 18% had documented benefit from treatment. The Scopulariopsis nail infections seem to be treatment-resistant and the pathogenesis and etiological role of Scopulariopsis remain poorly understood.

[1]  R. Summerbell,et al.  Onychomycosis: a critical study of techniques and criteria for confirming the etiologic significance of nondermatophytes. , 2005, Medical mycology.

[2]  Maria José Figueras,et al.  Atlas of clinical fungi. , 2005 .

[3]  M. A. Malecha.  Fungal Keratitis Caused by Scopulariopsis brevicaulis Treated Successfully With Natamycin , 2004, Cornea.

[4]  E. Bouza,et al.  Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp. , 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[5]  J. Perfect,et al.  Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. , 2004, The Journal of infection.

[6]  L. Argaud,et al.  Fatal Microascus trigonosporus (Anamorph Scopulariopsis) Pneumonia in a Bone Marrow Transplant Recipient , 2004, European Journal of Clinical Microbiology and Infectious Diseases.

[7]  S. Arikan,et al.  Skin infection caused by Scedosporium apiospermum , 2003, Mycoses.

[8]  B. Piraccini,et al.  Treatment of nondermatophyte mold and Candida onychomycosis. , 2003, Dermatologic clinics.

[9]  C. K. Campbell,et al.  Relationships of Scopulariopsis based on LSU rDNA sequences. , 2003, Medical mycology.

[10]  S. Zárraga,et al.  Case Reports. Infection due to Scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by Pseudallescheria boydii/Sc. apiospermum , 2002, Mycoses.

[11]  Daniel Lucey,et al.  Primary Cutaneous Fungal Infections in Solid Organ Transplantation: A Case Series , 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[12]  F. Makni,et al.  [Otomycosis due to Scopulariopsis brevicaulis]. , 2002, Revue de laryngologie - otologie - rhinologie.

[13]  R. Summerbell,et al.  Utility of Inoculum Counting (Walshe and English Criteria) in Clinical Diagnosis of Onychomycosis Caused by Nondermatophytic Filamentous Fungi , 2001, Journal of Clinical Microbiology.

[14]  V. Filipello Marchisio,et al.  Scopulariopsis brevicaulis: a keratinophilic or a keratinolytic fungus? , 2000, Mycoses.

[15]  J. Guarro,et al.  Biology of dermatophytes and other keratinophilic fungi , 2000 .

[16]  J. Guarro,et al.  Epidemiology of nail infection due to keratinophilic fungi. , 2000 .

[17]  M. Richardson,et al.  Model Systems for the Study of Dermatophyte and Non-Dermatophyte Invasion of Human Keratin , 2000 .

[18]  J. Marley,et al.  Non‐dermatophytes in onychomycosis of the toenails , 1997, The British journal of dermatology.

[19]  S. Stubb,et al.  The prevalence of onychomycosis in Finland , 1995, The British journal of dermatology.

[20]  K. Domsch,et al.  Compendium of Soil Fungi , 1995 .

[21]  J. Uitto,et al.  Disseminated cutaneous Pseudallescheria boydii , 1995, The British journal of dermatology.

[22]  Joost A. Stalpers,et al.  Ainsworth and Bisby's dictionary of the fungi: 9th edition. , 1995 .

[23]  E. Haneke.  Fungal infections of the nail. , 1991, Seminars in dermatology.

[24]  R. C. Summerbell,et al.  Onychomycosis, Tinea Pedis and Tinea Manuum Caused by Non‐Dermatophytic Filamentous Fungi Nicht‐Dermatophyten‐Fadenpilze als Erreger von Onychomykosen, Tinea pedis und Tinea manuum , 1989, Mycoses.

[25]  J. Guarro,et al.  Sordariaceous Ascomycetes Without Ascospore Ejaculation , 1988 .

[26]  Mary P. Eenglish.  NAILS AND FUNGI , 1976 .

[27]  J. Rippon.  Medical mycology;: The pathogenic fungi and the pathogenic actinomycetes , 2013 .

[28]  David L. Hawksworth,et al.  Ainsworth & Bisby's Dictionary of the Fungi , 1972 .