he Case for Shifting Borderline Personality isorder to Axis I

hrough reviewing what is known about the nature, course, and heritability of borderline personality disorder (BPD), we argue for a econceptualization of this disorder that would lead to its placement on Axis I. Borderline personality disorder is a prevalent and disabling ondition, and yet the empirical research into its nature and treatment has not been commensurate with the seriousness of the illness. We ot only review empirical evidence about the etiology, phenomenology, and course of the disorder in BPD but we also address fundamental isconceptions about BPD that we believe have contributed to misunderstanding and stigmatization of the disease. Finally, we suggest uture directions for research that might permit the identification of core features of this disorder, with a focus on the importance of aturalistic assessments and of assessments through the course of development.

[1]  Larry J Siever,et al.  Recent advances in the biological study of personality disorders. , 2008, The Psychiatric clinics of North America.

[2]  Jin Fan,et al.  Frontolimbic structural changes in borderline personality disorder. , 2008, Journal of psychiatric research.

[3]  J. Gunderson,et al.  Disturbed relationships as a phenotype for borderline personality disorder. , 2007, The American journal of psychiatry.

[4]  J. Paris The nature of borderline personality disorder: multiple dimensions, multiple symptoms, but one category. , 2007, Journal of personality disorders.

[5]  P. Pilkonis,et al.  Social domain dysfunction and disorganization in borderline personality disorder , 2007, Psychological Medicine.

[6]  J. Price,et al.  5HT2A Receptor Binding is Increased in Borderline Personality Disorder , 2007, Biological Psychiatry.

[7]  R. Kessler,et al.  DSM-IV Personality Disorders in the National Comorbidity Survey Replication , 2007, Biological Psychiatry.

[8]  K. Ressler,et al.  Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic , 2007, Nature Neuroscience.

[9]  Jin Fan,et al.  Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: An event-related fMRI study , 2007, Psychiatry Research: Neuroimaging.

[10]  D. Zuroff,et al.  Stability and variability of affective experience and interpersonal behavior in borderline personality disorder. , 2007, Journal of abnormal psychology.

[11]  C. Lejuez,et al.  Heightened sensitivity to facial expressions of emotion in borderline personality disorder. , 2006, Emotion.

[12]  J Douglas Bremner,et al.  Neuroimaging in borderline personality disorder. , 2006, Journal of psychiatric research.

[13]  T. McGlashan,et al.  Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. , 2006, The American journal of psychiatry.

[14]  M. Jovev,et al.  The relationship of borderline personality disorder, life events and functioning in an Australian psychiatric sample. , 2006, Journal of personality disorders.

[15]  M. Oquendo,et al.  Interpersonal precipitants and suicide attempts in borderline personality disorder. , 2006, Suicide & life-threatening behavior.

[16]  Klaus Scheffler,et al.  Neural correlates of antinociception in borderline personality disorder. , 2006, Archives of general psychiatry.

[17]  Min Yang,et al.  Prevalence and correlates of personality disorder in Great Britain , 2006, British Journal of Psychiatry.

[18]  J. Hennen,et al.  Prediction of the 10-year course of borderline personality disorder. , 2006, The American journal of psychiatry.

[19]  Jair C. Soares,et al.  Smaller Cingulate Volumes in Unipolar Depressed Patients , 2006, Biological Psychiatry.

[20]  Yueqin Huang,et al.  [A twin study of personality disorder heritability]. , 2006, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

[21]  J. Hennen,et al.  The McLean Study of Adult Development (MSAD): overview and implications of the first six years of prospective follow-up. , 2005, Journal of personality disorders.

[22]  R. Sullivan,et al.  Neurobiology of infant attachment. , 2005, Developmental psychobiology.

[23]  Monte S. Buchsbaum,et al.  Reduced Anterior and Posterior Cingulate Gray Matter in Borderline Personality Disorder , 2005, Biological Psychiatry.

[24]  Tomas Hajek,et al.  Neuroanatomical abnormalities as risk factors for bipolar disorder. , 2005, Bipolar disorders.

[25]  M. Zimmerman,et al.  The prevalence of DSM-IV personality disorders in psychiatric outpatients. , 2005, The American journal of psychiatry.

[26]  Nancy C Andreasen,et al.  Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications. , 2005, The American journal of psychiatry.

[27]  J. Paris Recent Advances in the Treatment of Borderline Personality Disorder , 2005 .

[28]  T. McGlashan,et al.  Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: toward a hybrid model of axis II disorders. , 2005, The American journal of psychiatry.

[29]  Mark Slifstein,et al.  Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. , 2005, The American journal of psychiatry.

[30]  E. Rüther,et al.  Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls , 2005, Psychiatry Research.

[31]  F. Frankenburg,et al.  The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of health care utilization. , 2004, The Journal of clinical psychiatry.

[32]  Harvard Medical School,et al.  Associations in the course of personality disorders and Axis I disorders over time. , 2004, Journal of abnormal psychology.

[33]  J. Hennen,et al.  Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. , 2004, The American journal of psychiatry.

[34]  D. Kupfer,et al.  Reduced left anterior cingulate volumes in untreated bipolar patients , 2004, Biological Psychiatry.

[35]  J. Hennen,et al.  Borderline psychopathology in the first-degree relatives of borderline and axis II comparison probands. , 2004, Journal of personality disorders.

[36]  D. Black,et al.  Suicidal behavior in borderline personality disorder: prevalence, risk factors, prediction, and prevention. , 2004, Journal of personality disorders.

[37]  R. O. Friedel Dopamine Dysfunction in Borderline Personality Disorder: A Hypothesis , 2004, Neuropsychopharmacology.

[38]  Jesse G. Brand,et al.  Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression , 2004, Psychopharmacology.

[39]  T. McGlashan,et al.  Childhood maltreatment associated with adult personality disorders: findings from the Collaborative Longitudinal Personality Disorders Study. , 2004, Journal of personality disorders.

[40]  E. Falkum,et al.  An investigation of the prototype validity of the borderline DSM‐IV construct , 2004, Acta psychiatrica Scandinavica.

[41]  C. Schmahl,et al.  New developments in the neurobiology of borderline personality disorder , 2004, Current psychiatry reports.

[42]  John C Gore,et al.  Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation , 2003, Biological Psychiatry.

[43]  L. Siever,et al.  Abuse and Neglect in Childhood: Relationship to Personality Disorder Diagnoses , 2003, CNS Spectrums.

[44]  J. Russo,et al.  Factors associated with high use of public mental health services by persons with borderline personality disorder. , 2003, Psychiatric services.

[45]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[46]  Louis Lemieux,et al.  Frontolimbic brain abnormalities in patients with borderline personality disorder a volumetric magnetic resonance imaging study , 2003, Biological Psychiatry.

[47]  P. Skudlarski,et al.  A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. , 2003, Archives of general psychiatry.

[48]  J. Paris Personality disorders over time: precursors, course and outcome. , 2003, Journal of personality disorders.

[49]  John H Krystal,et al.  Frontotemporal neural systems in bipolar disorder. , 2002, Seminars in clinical neuropsychiatry.

[50]  L. Siever,et al.  The borderline diagnosis III: identifying endophenotypes for genetic studies , 2002, Biological Psychiatry.

[51]  R. Yehuda,et al.  The Relationship Between Psychological Trauma and Borderline Personality Disorder , 2002 .

[52]  J. McGloin,et al.  Resilience among abused and neglected children grown up , 2001, Development and Psychopathology.

[53]  R. Blair,et al.  A Selective Impairment in the Processing of Sad and Fearful Expressions in Children with Psychopathic Tendencies , 2001, Journal of abnormal child psychology.

[54]  J. Paris,et al.  A 27-year follow-up of patients with borderline personality disorder. , 2001, Comprehensive psychiatry.

[55]  D. Zuroff,et al.  The Effect of Tryptophan on Social Interaction in Everyday Life: A Placebo-Controlled Study , 2001, Neuropsychopharmacology.

[56]  T. McGlashan,et al.  Treatment utilization by patients with personality disorders. , 2001, The American journal of psychiatry.

[57]  F. Coolidge,et al.  Heritability of personality disorders in childhood: a preliminary investigation. , 2001, Journal of personality disorders.

[58]  T. McGlashan,et al.  The Collaborative Longitudinal Personality Disorders Study: baseline Axis I/II and II/II diagnostic co‐occurrence , 2000, Acta psychiatrica Scandinavica.

[59]  T. McGlashan,et al.  Factor analysis of the DSM-III-R borderline personality disorder criteria in psychiatric inpatients. , 2000, The American journal of psychiatry.

[60]  Carolyn C Meltzer,et al.  A fenfluramine-activated FDG-PET study of borderline personality disorder , 2000, Biological Psychiatry.

[61]  J. Paris Childhood precursors of borderline personality disorder. , 2000, The Psychiatric clinics of North America.

[62]  S. Torgersen,et al.  Genetics of patients with borderline personality disorder. , 2000, The Psychiatric clinics of North America.

[63]  L. Siever,et al.  Neurotransmitter dysfunction in patients with borderline personality disorder. , 2000, The Psychiatric clinics of North America.

[64]  S. Kosslyn,et al.  Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. , 1999, The American journal of psychiatry.

[65]  J. Bjork,et al.  Laboratory measures of aggression and impulsivity in women with borderline personality disorder , 1999, Psychiatry Research.

[66]  J. Paris Does Childhood Trauma Cause Personality Disorders in Adults? , 1998, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[67]  E. Coccaro,et al.  Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. , 1997, Archives of general psychiatry.

[68]  H. Reinherz,et al.  The long-term sequelae of child and adolescent abuse: a longitudinal community study. , 1996, Child abuse & neglect.

[69]  P. Links,et al.  Borderline Psychopathology and Recurrences of Clinical Disorders , 1995, The Journal of nervous and mental disease.

[70]  J. Paris Memories of Abuse in Borderline Patients: True or False? , 1995, Harvard review of psychiatry.

[71]  S. Charles Schulz,et al.  Positron-Emission Tomography and Personality Disorders , 1994, Neuropsychopharmacology.

[72]  L. Siever,et al.  The serotonin system and aggressive personality disorder , 1993, International clinical psychopharmacology.

[73]  T. Dinan,et al.  Blunted Prolactin Responses to d-Fenfluramine in Sociopathy , 1992, British Journal of Psychiatry.

[74]  K. Phillips,et al.  Functional impairment in personality disorders. , 1992 .

[75]  L. Siever,et al.  A psychobiological perspective on the personality disorders. , 1991, The American journal of psychiatry.

[76]  L. Siever,et al.  Affective and impulsive personality disorder traits in the relatives of patients with borderline personality disorder. , 1991, The American journal of psychiatry.

[77]  K. Phillips,et al.  A current view of the interface between borderline personality disorder and depression. , 1991, The American journal of psychiatry.

[78]  L. Siever,et al.  Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. , 1989, Archives of general psychiatry.

[79]  J. C. Perry,et al.  Childhood trauma in borderline personality disorder. , 1989, The American journal of psychiatry.

[80]  S. Hurt,et al.  Comorbidity of borderline personality disorder. , 1988, Archives of general psychiatry.

[81]  H. Akiskal,et al.  Borderline: an adjective in search of a noun. , 1985, The Journal of clinical psychiatry.

[82]  J. Oldham,et al.  Familial transmission of DSM-III borderline personality disorder. , 1982, Archives of general psychiatry.

[83]  T. Dietrich,et al.  Processing of autobiographical memory retrieval cues in borderline personality disorder. , 2007, Journal of affective disorders.

[84]  P. Pilkonis,et al.  Evidence for a single latent class of Diagnostic and Statistical Manual of Mental Disorders borderline personality pathology. , 2007, Comprehensive psychiatry.

[85]  J. Price,et al.  HT 2 A Receptor Binding is Increased in Borderline ersonality Disorder , 2007 .

[86]  Arthur W Toga,et al.  Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. , 2004, The American journal of psychiatry.

[87]  Michael J. Anderle,et al.  The neural substrates of affective processing in depressed patients treated with venlafaxine. , 2003, The American journal of psychiatry.

[88]  J. Kelsoe Arguments for the genetic basis of the bipolar spectrum. , 2003, Journal of affective disorders.

[89]  M Diksic,et al.  Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. , 2001, The American journal of psychiatry.

[90]  D. Klein,et al.  A family study of outpatients with borderline personality disorder and no history of mood disorder. , 2000, Journal of personality disorders.

[91]  M. Linehan,et al.  Facial expression recognition ability among women with borderline personality disorder: implications for emotion regulation? , 1999, Journal of personality disorders.

[92]  J. Bailey,et al.  Does childhood sexual abuse cause borderline personality disorder? , 1999, Journal of sex & marital therapy.

[93]  A. Fossati,et al.  Latent structure analysis of DSM-IV borderline personality disorder criteria. , 1999, Comprehensive psychiatry.

[94]  A. Fossati,et al.  Borderline Personality Disorder and childhood sexual abuse: a meta-analytic study. , 1999, Journal of personality disorders.

[95]  F. Frankenburg,et al.  Pathways to the development of borderline personality disorder. , 1997, Journal of personality disorders.

[96]  Goldberg Sc,et al.  Is borderline personality disorder an illness , 1984 .

[97]  S. Guze,et al.  Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. , 1970, The American journal of psychiatry.

[98]  Ba,et al.  Fluorodeoxyglucose Positron Emission Tomography Response to Meta-chlorophenylpiperazine in Impulsive Aggression , 2022 .