Directional imaging of the retinal cone mosaic.

We describe a near-IR scanning laser ophthalmoscope that allows the retinal cone mosaic to be imaged in the human eye in vivo without the use of wave-front correction techniques. The method takes advantage of the highly directional quality of cone photoreceptors that permits efficient coupling of light to individual cones and subsequent detection of most directional components of the backscattered light produced by the light-guiding effect of the cones. We discuss details of the system and describe cone-mosaic images obtained under different conditions.

[1]  J. Yellott.  Spectral analysis of spatial sampling by photoreceptors: Topological disorder prevents aliasing , 1982, Vision Research.

[2]  David Williams,et al.  Optical fiber properties of individual human cones. , 2002, Journal of vision.

[3]  S A Burns,et al.  Direct measurement of human-cone-photoreceptor alignment. , 1995, Journal of the Optical Society of America. A, Optics, image science, and vision.

[4]  P Artal,et al.  High-resolution retinal images obtained by deconvolution from wave-front sensing. , 2000, Optics letters.

[5]  David Williams,et al.  The arrangement of the three cone classes in the living human eye , 1999, Nature.

[6]  R. Webb,et al.  Flying spot TV ophthalmoscope. , 1980, Applied optics.

[7]  P Artal,et al.  High-resolution imaging of the living human fovea: measurement of the intercenter cone distance by speckle interferometry. , 1989, Optics letters.

[8]  C. Squire.  Note on Reflection and Diffraction from Ice Crystals in the Sky , 1952 .

[9]  S A Burns,et al.  Comparison of cone directionality determined by psychophysical and reflectometric techniques. , 1999, Journal of the Optical Society of America. A, Optics, image science, and vision.

[10]  T. Hebert,et al.  Adaptive optics scanning laser ophthalmoscopy. , 2002, Optics express.

[11]  P Artal,et al.  Correction of the aberrations in the human eye with a liquid-crystal spatial light modulator: limits to performance. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[12]  J. Enoch.  Optical Properties of the Retinal Receptors , 1963 .

[13]  W. Stiles,et al.  The Luminous Efficiency of Rays Entering the Eye Pupil at Different Points , 1933 .

[14]  L. Ronchi,et al.  Directional scattering of light by the human retina. , 1952, Journal of the Optical Society of America.

[15]  Pablo Artal,et al.  Confocal scanning laser ophthalmoscope with adaptive optical wavefront correction , 2003, SPIE BiOS.

[16]  G. Blokland,et al.  Directionality and alignment of the foveal receptors, assessed with light scattered from the human fundusin vivo , 1986, Vision Research.

[17]  D R Williams,et al.  Supernormal vision and high-resolution retinal imaging through adaptive optics. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[18]  A. Hendrickson,et al.  Human photoreceptor topography , 1990, The Journal of comparative neurology.