Towards the ontological foundations of symbolic biological theories

OBJECTIVE Support for the symbolic representation of the physical structure of living organisms by an ontologically solid and logically sound foundation as a basis for formal reasoning. METHODS A set of canonical relations and attributes necessary for empirically adequate descriptions of biological entities is proposed. RESULTS It is shown how a broad range of biological organisms and their parts can be represented by cascading theories which are ordered by the dimensions of granularity, development, species, and canonicity. CONCLUSION The proposed representation of biological objects is non-redundant and compatible with inter- and intra-species similarities, developmental stages and pathological deviations.

[1]  Linda G. Shapiro,et al.  The digital anatomist structural abstraction: a scheme for the spatial description of anatomical entities , 1998, AMIA.

[2]  Barry Smith,et al.  The Cornucopia of Formal-Ontological Relations , 2005 .

[3]  J. Blake,et al.  Creating the Gene Ontology Resource : Design and Implementation The Gene Ontology Consortium 2 , 2001 .

[4]  A. Rector,et al.  Relations in biomedical ontologies , 2005, Genome Biology.

[5]  Alan L. Rector,et al.  Granularity, scale and collectivity: When size does and does not matter , 2006, J. Biomed. Informatics.

[6]  Michael F. Goodchild,et al.  Foundations of Geographic Information Science , 2003 .

[7]  Olivier Bodenreider,et al.  Of Mice and Men: Aligning Mouse and Human Anatomies , 2005, AMIA.

[8]  Werner Nutt,et al.  Basic Description Logics , 2003, Description Logic Handbook.

[9]  Cornelius Rosse,et al.  A Reference Ontology for Bioinformatics: The Foundational Model of Anatomy , 2003 .

[10]  Stefan Schulz,et al.  Biomedical ontologies: What part-of is and isn't , 2006, J. Biomed. Informatics.

[11]  Roberto Casati,et al.  Parts and Places: The Structures of Spatial Representation , 1999 .

[12]  Aldo Gangemi,et al.  The GALEN CORE Model Schemata for Anatomy: Towards a Re-usable Application-Independent Model of Medical Concepts , 2008 .

[13]  K. Cohen,et al.  Biomedical language processing: what's beyond PubMed? , 2006, Molecular cell.

[14]  Stefan Schulz,et al.  Medical knowledge reengineering - converting major portions of the UMLS into a terminological knowledge base , 2001, Int. J. Medical Informatics.

[15]  Fausto Giunchiglia,et al.  Local Models Semantics, or Contextual Reasoning = Locality + Compatibility , 1998, KR.

[16]  Joseph Henry Woodger,et al.  The axiomatic method in biology , 1938 .

[17]  José L. V. Mejino,et al.  A reference ontology for biomedical informatics: the Foundational Model of Anatomy , 2003, J. Biomed. Informatics.

[18]  Stefan Schulz,et al.  Parthood as Spatial Inclusion - Evidence from biomedical Conceptualizations , 2004, KR.

[19]  Bonnie L. Webber,et al.  Part-of Relations in Anatomy Ontologies: A Proposal for RDFS and OWL Formalisations , 2003, Pacific Symposium on Biocomputing.

[20]  Achille C. Varzi,et al.  Fiat and Bona Fide Boundaries , 2000 .

[21]  José L. V. Mejino,et al.  Pushing the envelope: challenges in a frame-based representation of human anatomy , 2004, Data Knowl. Eng..

[22]  Alan L. Rector,et al.  GALEN's model of parts and wholes: experience and comparisons , 2000, AMIA.

[23]  Asunción Gómez-Pérez,et al.  Knowledge Engineering and Knowledge Management: Ontologies and the Semantic Web , 2002, Lecture Notes in Computer Science.

[24]  Stefan Schulz,et al.  How to Distinguish Parthood from Location in Bio-Ontologies , 2005, AMIA.

[25]  José L. V. Mejino,et al.  Research Paper: Motivation and Organizational Principles for Anatomical Knowledge Representation: The Digital Anatomist Symbolic Knowledge Base , 1998, J. Am. Medical Informatics Assoc..

[26]  Maureen Donnelly Containment Relations in Anatomical Ontologies , 2005, AMIA.

[27]  Diego Calvanese,et al.  The Description Logic Handbook: Theory, Implementation, and Applications , 2003, Description Logic Handbook.

[28]  Stefan Schulz,et al.  Bidirectional mereological reasoning in anatomical knowledge bases , 2001, AMIA.

[29]  Stefan Schulz,et al.  Representing Natural Kinds by Spatial Inclusion and Containment , 2004, ECAI.

[30]  Nicola Guarino,et al.  Sweetening Ontologies with DOLCE , 2002, EKAW.

[31]  Bernhard Nebel,et al.  Principles of knowledge representation and reasoning: proceedings of the Third International Conference (KR'92) , 1992 .

[32]  Barry Smith,et al.  The Role of Foundational Relations in the Alignment of Biomedical Ontologies , 2004, MedInfo.

[33]  Diego Calvanese,et al.  The Description Logic Handbook , 2007 .

[34]  Richard Baldock,et al.  An ontology of human developmental anatomy , 2003, Journal of anatomy.

[35]  Thomas Bittner,et al.  A Theory of Granular Partitions , 2003, Foundations of Geographic Information Science.

[36]  Michael Y. Galperin The Molecular Biology Database Collection: 2006 update , 2005, Nucleic Acids Res..

[37]  Anthony G. Cohn,et al.  A Spatial Logic based on Regions and Connection , 1992, KR.

[38]  H. Herre,et al.  Ontological Categories in GOL , 2004 .