Developmental sequelae in infants having suffered severe perinatal asphyxia.

Abstract Fifteen of 20 infants surviving perinatal asphyxia (Apgar ≤ 3) necessitating resuscitation with positive-pressure oxygen and intravenous buffer were compared with 14 healthy mature nonasphyxiated infants 15 to 40 months after birth. Ten asphyxiated and 11 nonasphyxiated infants had normal neurologic examinations while two asphyxiated and three nonasphyxiated babies had borderline results. The three intrauterine growth-retarded babies in the asphyxia group all had neurologic deficits. Excluding these three badly damaged growth-retarded babies (mean I.Q. = 31), mean I.Q. scores of asphyxiated and nonasphyxiated groups were identical (96, asphyxiated; 96, nonasphyxiated). These preliminary data suggest a good prognosis for acutely asphyxiated infants managed with current techniques of resuscitation.

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