Evaluation of MCI Motor Performances During a Cognitive Dual Task Exercise

The increased level of interdisciplinarity, in the field of neuropsychology, has led to the shift from the idea that walking represents an automatic and simple gesture, to the notion that it is a complex task involving several cognitive abilities. This appraisal occurred by the increased use of Cognitive and Motor Dual-Task paradigms, and by the growing interest in quantitative gait analysis. In this framework, we aim to investigate the relationship between cognition and motor skills, and to apply insights gathered from this study to the diagnostic process of Dementia and Mild Cognitive Impairment. Here it is proposed an innovative technological tool able to quantify gait parameters while providing for a Motor and Cognitive Dual-Task. The results of this research show a significant statistical difference between subjects suffering from Mild Cognitive Impairment with and without planning deficits.

[1]  Jae-Wook Ryou,et al.  Making your next move: Dorsolateral prefrontal cortex and planning a sequence of actions in freely moving monkeys , 2004, Cognitive, affective & behavioral neuroscience.

[2]  T. Shallice Specific impairments of planning. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[3]  Jeffrey M. Hausdorff,et al.  Cognitive Involvement in Balance, Gait and Dual-Tasking in Aging: A Focused Review From a Neuroscience of Aging Perspective , 2018, Front. Neurol..

[4]  R. Ricci,et al.  Dual task-related gait changes in patients with mild cognitive impairment. , 2015, Functional neurology.

[5]  Xiaonan Xue,et al.  Quantitative gait dysfunction and risk of cognitive decline and dementia , 2007, Journal of Neurology, Neurosurgery & Psychiatry.

[6]  Angelo Maria Sabatini,et al.  In-use calibration of body-mounted gyroscopes for applications in gait analysis , 2005 .

[7]  Cecilia Laschi,et al.  Can physical and cognitive training based on episodic memory be combined in a new protocol for daily training? , 2018, Aging Clinical and Experimental Research.

[8]  Xiaonan Xue,et al.  Gait Dysfunction in Mild Cognitive Impairment Syndromes , 2008, Journal of the American Geriatrics Society.

[9]  Jeffrey M. Hausdorff,et al.  Gait and Cognition: A Complementary Approach to Understanding Brain Function and the Risk of Falling , 2012, Journal of the American Geriatrics Society.

[10]  O. Forlenza,et al.  Correlation between functional mobility and cognitive performance in older adults with cognitive impairment , 2018, Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.

[11]  Cecilia Laschi,et al.  Feasibility study on the assessment of auditory sustained attention through walking motor parameters in mild cognitive impairments and healthy subjects , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[12]  B. Rahm,et al.  Planning Abilities and the Tower of London: Is This Task Measuring a Discrete Cognitive Function? , 2004, Journal of clinical and experimental neuropsychology.

[13]  L. Bherer,et al.  Comparable Cerebral Oxygenation Patterns in Younger and Older Adults during Dual-Task Walking with Increasing Load , 2016, Front. Aging Neurosci..

[14]  Pierpaolo Sorrentino,et al.  Spatio-temporal and kinematic gait analysis in patients with Frontotemporal dementia and Alzheimer's disease through 3D motion capture. , 2017, Gait & posture.

[15]  L. Bherer,et al.  Comparing the Transfer Effects of Simultaneously and Sequentially Combined Aerobic Exercise and Cognitive Training in Older Adults , 2017 .

[16]  F. Cavallo,et al.  Comparative Motor Pre-clinical Assessment in Parkinson’s Disease Using Supervised Machine Learning Approaches , 2018, Annals of Biomedical Engineering.

[17]  A. Fasano,et al.  Gait patterns in parkinsonian patients with or without mild cognitive impairment , 2012, Movement disorders : official journal of the Movement Disorder Society.

[18]  L. Bosquet,et al.  Does Combined Physical and Cognitive Training Improve Dual-Task Balance and Gait Outcomes in Sedentary Older Adults? , 2017, Front. Hum. Neurosci..

[19]  Michael Schwenk,et al.  The Impact of Mild Cognitive Impairment on Gait and Balance: A Systematic Review and Meta-Analysis of Studies Using Instrumented Assessment , 2016, Gerontology.

[20]  Thomas J Grabowski,et al.  Limbic and Basal Ganglia Neuroanatomical Correlates of Gait and Executive Function: Older Adults With Mild Cognitive Impairment and Intact Cognition , 2017, American journal of physical medicine & rehabilitation.