Drug‐Binding Proteins in Liver Transplant Patients

Liver disease impairs the absorption, plasma protein binding, and metabolism of numerous drugs.1,2 Orthotopic liver transplantation is an accepted therapeutic option for patients with terminal liver failure.3 The liver is the primary site of plasma protein synthesis. Since a major determinant of the extent of drug binding to plasma proteins is the concentration of the drug-binding proteins, our objective was to measure the concentrations of two primary drug-binding proteins, albumin and alpha-1-acid glycoproteins (AAG), in stable liver transplant patients.