Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy

Water‐soluble metabolites extracted from 60 surgically excised samples of various brain tumors and four nontumorous lobectomized brains were measured quantitatively using in vitro high‐resolution magnetic resonance spectroscopy. A detailed MR spectrum–histology correlation study in a glioblastoma was made, to reveal MR spectral changes in accordance with the density of glioma cells. Furthermore, three cases that had difficult preoperative diagnoses are discussed.

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