SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

Abstract In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1.

[1]  P. Carmeliet,et al.  Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19 , 2021, The Lancet Respiratory Medicine.

[2]  K. To,et al.  Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  Sungyub Lew,et al.  Coinfection with SARS-CoV-2 and Influenza A Virus in a 32-Year-Old Man , 2020, The American journal of case reports.

[4]  D. Lauffenburger,et al.  Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters , 2020, Nature Medicine.

[5]  Tokiko Watanabe,et al.  Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development , 2020, Proceedings of the National Academy of Sciences.

[6]  L. García,et al.  Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 , 2020, Frontiers in Immunology.

[7]  Yoshihiro Kawaoka,et al.  Co-infection with SARS-CoV-2 and influenza A virus , 2020, IDCases.

[8]  Shalini Sharma,et al.  Virological and Immunological Outcomes of Coinfections , 2018, Clinical Microbiology Reviews.

[9]  T. Noda,et al.  Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection , 2017, Journal of Virology.

[10]  P. Klapper,et al.  Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality , 2014, Epidemiology and Infection.

[11]  P. Hulpiau,et al.  Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited , 2013, Microbiology and Molecular Reviews.

[12]  Walter Fiers,et al.  Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly , 2012, Journal of Virology.

[13]  Yongxin Hao,et al.  Pathology of guinea pigs experimentally infected with a novel reovirus and coronavirus isolated from SARS patients. , 2005, DNA and cell biology.

[14]  M. Horisberger,et al.  Interferons, Mx genes, and resistance to influenza virus. , 1995, American journal of respiratory and critical care medicine.

[15]  J. Waner,et al.  Mixed viral infections: detection and management , 1994, Clinical Microbiology Reviews.