Regioselective metalations of pyrimidines and pyrazines by using frustrated Lewis pairs of BF3·OEt2 and hindered magnesium- and zinc-amide bases.
暂无分享,去创建一个
T. Carell | P. Knochel | Klaus Groll | K. Karaghiosoff | Sophia M. Manolikakes | A. Bredihhin | Xavier Mollat du Jourdin | M. Jaric | Aleksei Bredihhin
[1] P. Knochel,et al. New preparation of TMPZnCl·LiCl by Zn insertion into TMPCl. Application to the functionalization of dibromodiazines. , 2013, Organic letters.
[2] P. Knochel,et al. Metalated N-heterocyclic reagents prepared by the frustrated Lewis pair TMPMgCl·BF3 and their addition to aromatic aldehydes and activated ketones. , 2013, Chemical communications.
[3] P. Bharatam,et al. C-H bond functionalization under metalation-deprotonation process: regioselective direct arylation of 3-aminoimidazo[1,2-a]pyrazine. , 2012, The Journal of organic chemistry.
[4] P. Baran,et al. Innate and guided C-H functionalization logic. , 2012, Accounts of chemical research.
[5] Yuebao Zhang,et al. Prins cyclization of bis(silyl) homoallylic alcohols to form 2,6-cis-tetrahydropyrans containing a geometrically defined exocyclic vinylsilane: efficient synthesis of ring B of the bryostatins. , 2012, Angewandte Chemie.
[6] Jian Lei,et al. [1,5]-Anion relay/[2,3]-Wittig rearrangement of 3,3-bis(silyl) allyl enol ethers: synthesis of useful vinyl bis(silane) species. , 2012, Organic letters.
[7] Junyi Hu,et al. Regiospecific synthesis of 1,2-disubstituted (hetero)aryl fused imidazoles with tunable fluorescent emission. , 2011, Organic letters.
[8] P. Knochel,et al. Regio‐ und chemoselektive Metallierung von Arenen und Heteroarenen mit gehinderten Metallamidbasen , 2011 .
[9] P. Knochel,et al. Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases. , 2011, Angewandte Chemie.
[10] J. A. Souto,et al. Enantioselektive metallfreie Diaminierung von Styrolen , 2011 .
[11] José A. Souto,et al. Enantioselective metal-free diamination of styrenes. , 2011, Angewandte Chemie.
[12] P. Knochel,et al. Selective and multiple functionalization of pyridines and alkaloids via Mg- and Zn-organometallic intermediates. , 2011, Organic letters.
[13] G. Plé,et al. A new series of rod-like conjugated molecules with a pyrazine or a bipyrazine core. Synthesis and light emitting properties , 2011 .
[14] T. Carell,et al. Trifunctionalization of the purine scaffold using Mg and Zn organometallic intermediates. , 2011, Organic letters.
[15] Kilian Muñiz,et al. Eine intermolekulare Palladium‐katalysierte vicinale Diaminierung von nichtaktivierten Alkenen , 2010 .
[16] K. Muñiz,et al. An intermolecular palladium-catalyzed diamination of unactivated alkenes. , 2010, Angewandte Chemie.
[17] P. Knochel,et al. Hoch selektive Metallierungen von Pyridinen und verwandten Heterocyclen mithilfe frustrierter Lewis-Paare sowie tmp-Zink- und tmp-Magnesium-Basen mit BF3⋅OEt2† , 2010 .
[18] P. Knochel,et al. Highly selective metalations of pyridines and related heterocycles using new frustrated Lewis pairs or tmp-zinc and tmp-magnesium bases with BF3.OEt2. , 2010, Angewandte Chemie.
[19] P. Herdewijn,et al. Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues. , 2010, Bioorganic & medicinal chemistry letters.
[20] G. Erker,et al. Frustrierte Lewis‐Paare: metallfreie Wasserstoffaktivierung und mehr , 2010 .
[21] Douglas W Stephan,et al. Frustrated Lewis pairs: metal-free hydrogen activation and more. , 2010, Angewandte Chemie.
[22] Enrico Perspicace,et al. Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives. , 2009, Organic & biomolecular chemistry.
[23] X. Chen,et al. Palladium(II)‐katalysierte C‐H‐Aktivierung/C‐C‐Kreuzkupplung: Vielseitigkeit und Anwendbarkeit , 2009 .
[24] jin-quan yu,et al. Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality. , 2009, Angewandte Chemie.
[25] P. Knochel,et al. TMPZnCl.LiCl: a new active selective base for the directed zincation of sensitive aromatics and heteroaromatics. , 2009, Organic letters.
[26] P. Knochel,et al. Regio- and chemoselective metalation of chloropyrimidine derivatives with TMPMgCl x LiCl and TMP(2)Zn x 2 MgCl(2) x 2 LiCl. , 2009, Chemistry.
[27] F. Mohr,et al. Are Organotin Reagents Derived from Bis(trimethylsilyl)picoline Suitable Precursors for the Preparation of Cyclometallated Complexes , 2009 .
[28] A. Derdour,et al. Deprotonative cadmation of functionalized aromatics. , 2008, Chemical communications.
[29] P. Knochel,et al. Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl. , 2008, Organic & biomolecular chemistry.
[30] S. Lata,et al. A study of BF3-promoted ortho lithiation of anilines and DFT calculations on the role of fluorine-lithium interactions. , 2008, Angewandte Chemie.
[31] P. Knochel,et al. Regio- and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl.LiCl. , 2008, Organic letters.
[32] Tibor András Rokob,et al. Turning frustration into bond activation: a theoretical mechanistic study on heterolytic hydrogen splitting by frustrated Lewis pairs. , 2008, Angewandte Chemie.
[33] F. Chevallier,et al. Functionalization of diazines and benzo derivatives through deprotonated intermediates. , 2008, Chemical Society reviews.
[34] P. Knochel,et al. Direkte Magnesierung funktionalisierter Arene und Heteroarene mit (tmp)2Mg⋅2 LiCl† , 2007 .
[35] P. Knochel,et al. Direct magnesiation of polyfunctionalized arenes and heteroarenes using (tmp)(2)Mg x 2LiCl. , 2007, Angewandte Chemie.
[36] M. Vaultier,et al. Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline. , 2007, The Journal of organic chemistry.
[37] J. White,et al. Solution and Solid-State Structure of 2- and 4-Bis(trimethylsilyl)methylpyridinium Cations , 2007 .
[38] David R. Williams,et al. Reactivity studies of 3,3-bis(trimethylsilyl)-2-methyl-1-propene in Lewis acid-catalyzed allylation reactions. , 2006, Organic letters.
[39] W. Clegg,et al. Alkali-metal-mediated zincation of anisole: synthesis and structures of three instructive ortho-zincated complexes. , 2006, Journal of the American Chemical Society.
[40] P. Knochel,et al. Gemischte Mg/Li-Amide des Typs R2NMgCl⋅LiCl als hoch effiziente Basen zur regioselektiven Synthese funktionalisierter Aryl- und Heteroarylmagnesium-Verbindungen† , 2006 .
[41] P. Knochel,et al. Mixed Mg/Li amides of the type R2NMgCl.LiCl as highly efficient bases for the regioselective generation of functionalized aryl and heteroaryl magnesium compounds. , 2006, Angewandte Chemie.
[42] Raluca M. Fratila,et al. Synthesis of type II beta-turn surrogate dipeptides based on syn-alpha-amino-alpha,beta-dialkyl-beta-lactams. , 2004, Organic letters.
[43] R. Pohl,et al. Facile and efficient synthesis of 6-(hydroxymethyl)purines. , 2004, Organic letters.
[44] B. Skelton,et al. Synthesis and spectroscopic studies of organometallic Mn(I) complexes containing the novel mixed donor ligands 2-{MeSeCH(2−n)(SiMe3)n}C5H4N (n=0–2) , 2003 .
[45] D. Ager,et al. New developments in the Peterson olefination reaction. , 2002, Chemical Society reviews.
[46] S. Peng,et al. Suzuki coupling approach for the synthesis of phenylene-pyrimidine alternating oligomers for blue light-emitting material. , 2002, Organic letters.
[47] F. Mongin,et al. Advances in the directed metallation of azines and diazines (pyridines, pyrimidines, pyrazines, pyridazines, quinolines, benzodiazines and carbolines). Part 2: Metallation of pyrimidines, pyrazines, pyridazines and benzodiazines , 2001 .
[48] D. M. Hodgson,et al. Palladium-catalysed isomerisation of vinyldisilanes to allyldisilanes , 2001 .
[49] A. Turck,et al. Synthesis of 4,8-Diarylcinnolines and Quinazolines with Potential Applications in Nonlinear Optics. Diazines. Part 28 , 2000 .
[50] Chemla,et al. Fritsch-Buttenberg-Wiechell rearrangement in the aliphatic series , 2000, Organic letters.
[51] A. Johnson,et al. A general synthesis of 1-(1-alkenyl)benzotriazoles , 1999 .
[52] Y. Kondo,et al. TMP−Zincate as Highly Chemoselective Base for Directed Ortho Metalation , 1999 .
[53] S. Shuto,et al. A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides , 1997 .
[54] J. Aizpurua,et al. A Contribution to the Asymmetric Synthesis of 3‐Amino β‐Lactams: The Diastereoselective [2+2] Cycloaddition Reaction of Chiral Aminoketene Equivalents with Enolizable Aldehyde‐Derived Imines , 1997 .
[55] I. Marek,et al. Synthesis of Polysubstituted Stereodefined Olefins via the Reactivity of sp2 Organo-gem-bismetallics , 1996 .
[56] A. Turck,et al. Diazines 13: Metalation without Ortho-Directing Group - Functionalization of Diazines via Direct Metalation , 1995 .
[57] Y. V. D. van der Burgt,et al. New Diphosphine Ligands Based on Heterocyclic Aromatics Inducing Very High Regioselectivity in Rhodium-Catalyzed Hydroformylation: Effect of the Bite Angle , 1995 .
[58] M. Lautens,et al. A Regioselective Palladium‐Catalyzed Reduction of 3,3‐Heterobimetalated Allylic Acetates— Synthesis and Reactivity of Allylic Bimetallic Compounds , 1995 .
[59] Mark Lautens,et al. Regioselektive Palladium‐katalysierte Reduktion von 3,3‐heterodimetallierten Allylacetaten – Synthese und Reaktivität von dimetallierten Allylverbindungen , 1994 .
[60] V. Farina,et al. Large rate accelerations in the stille reaction with tri-2-furylphosphine and triphenylarsine as palladium ligands: mechanistic and synthetic implications , 1991 .
[61] Paramjit Singh,et al. Lewis acid complexed heteroatom carbanions; a new concept for α-metallation of tertiary amines , 1991 .
[62] A. Turck,et al. Metallation of diazines II. First metallation of pyridazine, metallation of 2,4‐dichloropyrimidine , 1990 .
[63] F. Cossío,et al. A new version of the peterson olefination using bis(trimethylsilyl)methyl derivatives and fluoride ion as catalyst , 1990 .
[64] N. Taylor,et al. Directed ortho metalation of N,N-diethylbenzamides. Silicon protection of ortho sites and the o-methyl group , 1989 .
[65] J. Lasarte,et al. Fluoride ion mediated peterson alkenation of bis(trimethylsilyl)methylimines: a novel synthesis of 2-aza-1,3-dienes and N-vinyl-β-lactams , 1989 .
[66] C. Raston,et al. Syntheses and crystal structures of complexes [M2R2][M = Cu, Ag, or Au; R = 2-C(SiMe3)2C5H4N] and [Cu4R′4][R′= 2-CH(SiMe3)C5H4N]; electrochemical generation of [Cu2R2]2+ , 1987 .
[67] J. Chruściel,et al. A new anion rearrangement involving silyl migration to oxygen , 1984 .
[68] V. Snieckus,et al. Directed metalation of tertiary benzamides. Silicon protection of ortho sites and ortho methyl groups , 1983 .
[69] H. Breunig,et al. Bis- and tris-(trimethylsilyl)methyl derivatives of antimony , 1983 .
[70] E. Negishi. Palladium- or nickel-catalyzed cross coupling. A new selective method for carbon-carbon bond formation , 1982 .
[71] I. Fleming,et al. The reactions of tris(trimethylsilyl)methyl-lithium with some carbon electrophiles , 1981 .
[72] E. Negishi,et al. Palladium-catalyzed cross-coupling reaction of homoallylic or homopropargylic organozincs with alkenyl halides as a new selective route to 1,5-dienes and 1,5-enynes , 1980 .
[73] R. Hoffmann,et al. Carben-reaktionen XIII cycloheptatrienyliden aus trimethylsilyl-tropylium-tetrafluoroborat , 1978 .
[74] Makoto Kumada,et al. Selective carbon-carbon bond formation by cross-coupling of Grignard reagents with organic halides. Catalysis by nickel-phosphine complexes , 1972 .
[75] R. Corriu,et al. Activation of Grignard reagents by transition-metal complexes. A new and simple synthesis of trans-stilbenes and polyphenyls , 1972 .