Development and validation of a Monte Carlo simulation of photon transport in an Anger camera.

The geometric component of the point spread function (PSF) of a gamma camera collimator can be determined analytically, and the penetration component can be calculated readily by numerical ray-tracing. A Monte Carlo simulation of photon transport which includes collimator scatter is developed. The simulation was implemented with an array processor which propagates up to 1024 photons in parallel, allowing accurate estimates of the total radial PSF in less than a day. The simulation was tested by imaging monoenergetic point sources of Tc-99m, Cr-51, and Sr-85 (140, 320, and 514 keV, respectively) on a General Electric Star Cam with low-energy, general-purpose, and medium-energy collimators. Comparisons of measured and simulated PSFs demonstrate the validity of the model and the significance of collimator scatter in the degradation of image quality.

[1]  Biodistribution and radiation dosimetry of radioiodinated-SCH 23982, a potential dopamine D-1 receptor imaging agent. , 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  C E Floyd,et al.  Monte Carlo evaluation of Compton scatter subtraction in single photon emission computed tomography. , 1985, Medical physics.

[3]  W. Leslie Rogers,et al.  Application of Monte-Carlo Methods to the Design of Spect Detector Systems , 1985, IEEE Transactions on Nuclear Science.

[4]  P. Doherty,et al.  Use of indium-111-labeled OC-125 monoclonal antibody in the detection of ovarian cancer , 1987 .

[5]  Glenn F. Knoll,et al.  Results of Scattering in Radioisotope Imaging , 1973 .

[6]  M. Albert,et al.  Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography. , 1985, JAMA.

[7]  C E Floyd,et al.  Energy and spatial distribution of multiple order Compton scatter in SPECT: a Monte Carlo investigation. , 1984, Physics in medicine and biology.

[8]  C E Metz,et al.  The geometric transfer function component for scintillation camera collimators with straight parallel holes. , 1980, Physics in medicine and biology.

[9]  R. Baldwin,et al.  Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain. , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  Robert N. Beck,et al.  Collimator Design Using Ray-Tracing Techniques , 1985, IEEE Transactions on Nuclear Science.

[11]  M. S. Rosenthal,et al.  TECHNICAL NOTE: Scattering in uniform media (for correction of nuclear medicine images) , 1990 .

[12]  H. Anger SCINTILLATION CAMERA WITH MULTICHANNEL COLLIMATORS. , 1964, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  C E Floyd,et al.  Experimentally measured scatter fractions and energy spectra as a test of Monte Carlo simulations. , 1987, Physics in medicine and biology.

[14]  R. Siddon Fast calculation of the exact radiological path for a three-dimensional CT array. , 1985, Medical physics.

[15]  D E Raeside,et al.  Monte Carlo principles and applications. , 1976, Physics in medicine and biology.

[16]  Ronald J. Jaszczak,et al.  Analysis of SPECT including Scatter and Attenuation Using Sophisticated Monte Carlo Modeling Methods , 1982, IEEE Transactions on Nuclear Science.

[17]  K Doi,et al.  The validity of Monte Carlo simulation in studies of scattered radiation in diagnostic radiology. , 1983, Physics in medicine and biology.

[18]  T. Budinger,et al.  External imaging of cerebral muscarinic acetylcholine receptors. , 1984, Science.

[19]  J. H. Hubbell,et al.  Atomic form factors, incoherent scattering functions, and photon scattering cross sections , 1975 .

[20]  C E Floyd,et al.  Deconvolution of Compton scatter in SPECT. , 1985, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  R. Paxton,et al.  Preoperative imaging of colorectal carcinoma with 111In-labeled anticarcinoembryonic antigen monoclonal antibody. , 1986, Cancer research.

[22]  G Muehllehner,et al.  Septal penetration in scintillation camera collimators. , 1973, Physics in medicine and biology.