Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
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Sandip K. Mishra | J. Gumin | F. Lang | T. Amano | A. Nakamizo | N. Shinojima | R. Sawaya
[1] T. Shono,et al. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. , 2008, Neuro-oncology.
[2] M. Mumby. PP2A: Unveiling a Reluctant Tumor Suppressor , 2007, Cell.
[3] M. Kastan. Wild-Type p53: Tumors Can't Stand It , 2007, Cell.
[4] D. Herr,et al. Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression , 2006, The EMBO journal.
[5] J. Roth. Adenovirus p53 gene therapy , 2006, Expert opinion on biological therapy.
[6] L. Mayo,et al. Phosphorylation of Human p53 at Serine 46 Determines Promoter Selection and whether Apoptosis Is Attenuated or Amplified* , 2005, Journal of Biological Chemistry.
[7] Hong Yang,et al. Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis*♦ , 2004, Journal of Biological Chemistry.
[8] Zigang Dong,et al. Post-translational modification of p53 in tumorigenesis , 2004, Nature Reviews Cancer.
[9] F. McCormick,et al. Role for PP2A in ARF signaling to p53. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[10] T. Jacks,et al. Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23 , 2004, The EMBO journal.
[11] R. Iggo,et al. Regulation of p53 Stability and Function in HCT116 Colon Cancer Cells* , 2004, Journal of Biological Chemistry.
[12] S. Lowe,et al. Control of apoptosis by p53 , 2003, Oncogene.
[13] E. Appella,et al. Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress* , 2003, Journal of Biological Chemistry.
[14] Susan M. Chang,et al. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] S. Hirschfeld,et al. Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] S. Lowe,et al. Dissecting p53 tumor suppressor functions in vivo. , 2002, Cancer cell.
[17] T. Shono,et al. Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. , 2002, Cancer research.
[18] R. Iggo,et al. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[19] W. Yung,et al. Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis. , 2001, Neuro-oncology.
[20] Wei Zhang,et al. Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies. , 2001, International journal of molecular medicine.
[21] J. Roth,et al. Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts , 2001, International journal of radiation biology.
[22] P. Tofilon,et al. Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation. , 2000, International journal of radiation oncology, biology, physics.
[23] K. Vousden,et al. Minireviewp 53 : Death Star able to induce the defensive p 53 response to oncogene , 2000 .
[24] Yusuke Nakamura,et al. p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53 , 2000, Cell.
[25] E. Stavridi,et al. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[26] W. Yung,et al. Adenovirus-mediated p53 gene therapy for human gliomas. , 1999, Neurosurgery.
[27] P. Howley,et al. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity , 1999, Oncogene.
[28] T. Liu,et al. Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines , 1999, Cancer Gene Therapy.
[29] M. Kubbutat,et al. Regulation of p53 Function and Stability by Phosphorylation , 1999, Molecular and Cellular Biology.
[30] A. Giaccia,et al. The complexity of p53 modulation: emerging patterns from divergent signals. , 1998, Genes & development.
[31] W. Yung,et al. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. , 1998, Journal of neurosurgery.
[32] T. McDonnell,et al. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. , 1997, Journal of the National Cancer Institute.
[33] W. Yung,et al. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. , 1996, Cancer research.
[34] F. Graham,et al. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[35] E. Newcomb,et al. p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. , 1992, Cancer research.
[36] Tim Crook,et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human , 2003, Nature Genetics.