Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

[1]  M. Caron,et al.  Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.

[2]  J. Rodríguez-Fernández,et al.  Bombesin, Vasopressin, Lysophosphatidic Acid, and Sphingosylphosphorylcholine Induce Focal Adhesion Kinase Activation in Intact Swiss 3T3 Cells* , 1998, The Journal of Biological Chemistry.

[3]  Robert J. Lefkowitz,et al.  G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.

[4]  T. Gudermann,et al.  Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5]  B. Slack.  Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Schlessinger,et al.  Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling* , 1998, The Journal of Biological Chemistry.

[7]  J. Haskill,et al.  A Calcium-dependent Tyrosine Kinase Splice Variant in Human Monocytes , 1998, The Journal of Biological Chemistry.

[8]  H. Kawakatsu,et al.  Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells* , 1998, The Journal of Biological Chemistry.

[9]  G. Condorelli,et al.  Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway* , 1998, The Journal of Biological Chemistry.

[10]  J. Gutkind.  The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* , 1998, The Journal of Biological Chemistry.

[11]  J. Guan,et al.  Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK) , 1998, The Journal of Biological Chemistry.

[12]  L. Graves,et al.  Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor , 1998, The Journal of Biological Chemistry.

[13]  M. Caron,et al.  Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.

[14]  R. Lefkowitz,et al.  G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts , 1997, The Journal of Biological Chemistry.

[15]  A. Ullrich,et al.  Signal characteristics of G protein‐transactivated EGF receptor , 1997, The EMBO journal.

[16]  Robert J. Lefkowitz,et al.  Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A , 1997, Nature.

[17]  M. Marrero,et al.  Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor* , 1997, The Journal of Biological Chemistry.

[18]  I. Dusanter-Fourt,et al.  The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). , 1997, European journal of biochemistry.

[19]  E. Peralta,et al.  The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity , 1997, The EMBO journal.

[20]  R. Lefkowitz,et al.  Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. , 1997, The Journal of biological chemistry.

[21]  P. Crespo,et al.  Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ , 1997, Science.

[22]  S. Schmid,et al.  Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis , 1996, Science.

[23]  R. Lefkowitz,et al.  Mitogenic signaling via G protein-coupled receptors. , 1996, Endocrine reviews.

[24]  E. Rozengurt,et al.  Bombesin, Bradykinin, Vasopressin, and Phorbol Esters Rapidly and Transiently Activate Src Family Tyrosine Kinases in Swiss 3T3 Cells , 1996, The Journal of Biological Chemistry.

[25]  S. Lev,et al.  A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation , 1996, Nature.

[26]  J. Benovic,et al.  β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor , 1996, Nature.

[27]  T. Hunter,et al.  Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK. , 1996, Cell structure and function.

[28]  Robert J. Lefkowitz,et al.  Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases* , 1996, The Journal of Biological Chemistry.

[29]  R. Lefkowitz,et al.  Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway (*) , 1996, The Journal of Biological Chemistry.

[30]  J. Pouysségur,et al.  Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein‐coupled thrombin receptor. , 1996, The EMBO journal.

[31]  A. Ullrich,et al.  Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors , 1996, Nature.

[32]  J. Sadoshima,et al.  The heterotrimeric G q protein‐coupled angiotensin II receptor activates p21 ras via the tyrosine kinase‐Shc‐Grb2‐Sos pathway in cardiac myocytes. , 1996, The EMBO journal.

[33]  M. Caron,et al.  Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.

[34]  M. Ishida,et al.  Angiotensin II activates pp60c-src in vascular smooth muscle cells. , 1995, Circulation research.

[35]  M. Runge,et al.  Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells (*) , 1995, The Journal of Biological Chemistry.

[36]  R. Lefkowitz,et al.  Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway , 1995, Nature.

[37]  E. Peles,et al.  Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions , 1995, Nature.

[38]  G. Bokoch,et al.  G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes (*) , 1995, The Journal of Biological Chemistry.

[39]  R. Lefkowitz,et al.  Distinct Pathways of G- and G-mediated Mitogen-activated Protein Kinase Activation (*) , 1995, The Journal of Biological Chemistry.

[40]  L. Heasley,et al.  G protein-coupled receptor systems involved in cell growth and oncogenesis. , 1995, Endocrine reviews.

[41]  C. Benjamin,et al.  Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells (*) , 1995, The Journal of Biological Chemistry.

[42]  B. Berk,et al.  Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor , 1995, Nature.

[43]  R. Lefkowitz,et al.  Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[44]  J. Pouysségur,et al.  Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. , 1994, The Journal of biological chemistry.

[45]  A. Strosberg,et al.  Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes. , 1994, The Journal of biological chemistry.

[46]  P. Crespo,et al.  Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits , 1994, Nature.

[47]  H. Bourne,et al.  cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. , 1994, The Journal of biological chemistry.

[48]  A. Saltiel,et al.  Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. , 1994, The Journal of biological chemistry.

[49]  P. Hordijk,et al.  Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. , 1994, The Journal of biological chemistry.

[50]  G. Milligan,et al.  Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. , 1993, The Journal of biological chemistry.

[51]  N. Qian,et al.  Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. , 1993, The Journal of biological chemistry.

[52]  Á. Valverde,et al.  Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. , 1993, The Journal of biological chemistry.

[53]  R. Medema,et al.  Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[54]  I. Nishimoto,et al.  Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation , 1991, Cell.

[55]  Richard G. W. Anderson.  The caveolae membrane system. , 1998, Annual review of biochemistry.

[56]  R. Lefkowitz,et al.  Desensitization of G protein-coupled receptors. , 1996, Recent progress in hormone research.