Designing degradable hydrogels for orthogonal control of cell microenvironments

This review provides insight into emerging degradable and cell-compatible hydrogels for understanding and modulating cell behavior for various bioengineering applications.

[1]  H. Kong,et al.  Hydrogels used for cell-based drug delivery. , 2008, Journal of biomedical materials research. Part A.

[2]  W. Lyoo,et al.  Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. , 2008, International journal of pharmaceutics.

[3]  Yang Yang,et al.  Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds , 2011 .

[4]  J. Rubin,et al.  Direct synthesis of biodegradable polysaccharide derivative hydrogels through aqueous Diels-Alder chemistry. , 2011, Macromolecular rapid communications.

[5]  Jan P Stegemann,et al.  Thermogelling chitosan and collagen composite hydrogels initiated with beta-glycerophosphate for bone tissue engineering. , 2010, Biomaterials.

[6]  Sung Hye Kim,et al.  Cell-mediated Delivery and Targeted Erosion of Vascular Endothelial Growth Factor-Crosslinked Hydrogels. , 2010, Macromolecular rapid communications.

[7]  Isabelle Migneault,et al.  Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking. , 2004, BioTechniques.

[8]  H. Bianco-Peled,et al.  Composite alginate hydrogels: An innovative approach for the controlled release of hydrophobic drugs. , 2010, Acta biomaterialia.

[9]  C A van Blitterswijk,et al.  Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. , 2010, Acta biomaterialia.

[10]  Celeste M Nelson,et al.  Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. , 2012, Biophysical journal.

[11]  K. Varaprasad,et al.  Design and development of temperature sensitive porous poly(NIPAAm‐AMPS) hydrogels for drug release of doxorubicin‐a cancer chemotherapy drug , 2010 .

[12]  A. Metters,et al.  A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks , 2000 .

[13]  W. King,et al.  Geometric microenvironment directs cell morphology on topographically patterned hydrogel substrates. , 2010, Acta biomaterialia.

[14]  Carsten Werner,et al.  A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. , 2009, Biomaterials.

[15]  Sytze J Buwalda,et al.  Stereocomplexed 8-armed poly(ethylene glycol)–poly(lactide) star block copolymer hydrogels: Gelation mechanism, mechanical properties and degradation behavior , 2012 .

[16]  A. Freemont,et al.  Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. , 2008, Biomaterials.

[17]  H. Hall Modified fibrin hydrogel matrices: both, 3D-scaffolds and local and controlled release systems to stimulate angiogenesis. , 2007, Current pharmaceutical design.

[18]  Yu-Hsin Lin,et al.  Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs. , 2005, Biomaterials.

[19]  Buddy D Ratner,et al.  Photo-patterning of porous hydrogels for tissue engineering. , 2007, Biomaterials.

[20]  Michael V. Turturro,et al.  Synthetic PEG Hydrogels as Extracellular Matrix Mimics for Tissue Engineering Applications , 2012 .

[21]  J. Stadler,et al.  PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism Studies , 2007, Drug Metabolism and Disposition.

[22]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[23]  A. Khademhosseini,et al.  Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[24]  David J. Mooney,et al.  Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate , 2010, Nature materials.

[25]  Wim E Hennink,et al.  The effect of photopolymerization on stem cells embedded in hydrogels. , 2009, Biomaterials.

[26]  K. Anseth,et al.  A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[27]  Heungsoo Shin,et al.  Control of adhesion, focal adhesion assembly, and differentiation of myoblasts by enzymatically crosslinked cell-interactive hydrogels , 2011 .

[28]  B. Harley,et al.  The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells. , 2012, Biomaterials.

[29]  Yu-Li Wang,et al.  A photo-modulatable material for probing cellular responses to substrate rigidity. , 2009, Soft matter.

[30]  Kristi S. Anseth,et al.  Mechanical Properties and Degradation of Chain and Step-Polymerized Photodegradable Hydrogels , 2013, Macromolecules.

[31]  Wim E Hennink,et al.  Hydrogels for protein delivery. , 2012, Chemical reviews.

[32]  Lin Yu,et al.  Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[33]  Kirk Czymmek,et al.  Injectable solid peptide hydrogel as a cell carrier: effects of shear flow on hydrogels and cell payload. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[34]  Patrick S Doyle,et al.  Bar-coded hydrogel microparticles for protein detection: synthesis, assay and scanning , 2011, Nature Protocols.

[35]  B. Cash,et al.  Systematic Review: FDA-Approved Prescription Medications for Adults With Constipation. , 2006, Gastroenterology & hepatology.

[36]  M. Bissell,et al.  Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. , 2006, Annual review of cell and developmental biology.

[37]  Brian A. Aguado,et al.  Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. , 2012, Tissue engineering. Part A.

[38]  T. Hoare,et al.  Injectable, Degradable Thermoresponsive Poly(N-isopropylacrylamide) Hydrogels. , 2012, ACS macro letters.

[39]  Shreyas S. Rao,et al.  Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors , 2012, PloS one.

[40]  Hongzhi Zhou,et al.  The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering. , 2011, Biomaterials.

[41]  Kristyn S Masters,et al.  Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. , 2005, Biomaterials.

[42]  P. Russell,et al.  The role of substratum compliance of hydrogels on vascular endothelial cell behavior. , 2011, Biomaterials.

[43]  David G Baer,et al.  A PEGylated fibrin-based wound dressing with antimicrobial and angiogenic activity. , 2011, Acta biomaterialia.

[44]  D. Irvine,et al.  Directed cell migration via chemoattractants released from degradable microspheres. , 2005, Biomaterials.

[45]  Linfeng Wu,et al.  Modifying the release of proxyphylline from PVA hydrogels using surface crosslinking. , 2008, International journal of pharmaceutics.

[46]  A. Metters,et al.  Hydrogels in controlled release formulations: network design and mathematical modeling. , 2006, Advanced drug delivery reviews.

[47]  Mark W. Tibbitt,et al.  Hydrogels as extracellular matrix mimics for 3D cell culture. , 2009, Biotechnology and bioengineering.

[48]  E. Balazs,et al.  The chemistry, biology and medical applications of hyaluronan and its derivatives , 1998 .

[49]  F. Guilak,et al.  Control of stem cell fate by physical interactions with the extracellular matrix. , 2009, Cell stem cell.

[50]  S. Rizzi,et al.  Elucidating the role of matrix stiffness in 3D cell migration and remodeling. , 2011, Biophysical journal.

[51]  David F. Williams On the mechanisms of biocompatibility. , 2008, Biomaterials.

[52]  Mingzhu Liu,et al.  Synthesis and characterization of thermo- and pH-sensitive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-itaconic acid) semi-IPN hydrogels , 2012, Biomedical materials.

[53]  Feng Xu,et al.  Engineering hydrogels as extracellular matrix mimics. , 2010, Nanomedicine.

[54]  H. Ohtake,et al.  Hyaluronic acid production by recombinant Streptococcus thermophilus. , 2011, Journal of bioscience and bioengineering.

[55]  T. Blunk,et al.  Enzymatically degradable poly(ethylene glycol) based hydrogels for adipose tissue engineering. , 2010, Biomaterials.

[56]  J. Yang,et al.  A novel injectable chitosan/polyglutamate polyelectrolyte complex hydrogel with hydroxyapatite for soft-tissue augmentation. , 2012, Carbohydrate polymers.

[57]  Kristi S Anseth,et al.  Student award for outstanding research winner in the Ph.D. category for the 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: synthesis and application of photodegradable microspheres for spatiotemporal control of protein delivery. , 2012, Journal of biomedical materials research. Part A.

[58]  Thomas Boudou,et al.  A hitchhiker's guide to mechanobiology. , 2011, Developmental cell.

[59]  Xian Xu,et al.  Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks. , 2012, Soft matter.

[60]  Barbara D Boyan,et al.  A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[61]  D. Klee,et al.  Synthesis and characterization of poly(vinyl alcohol)‐graft‐[poly(D,L‐lactide)/poly(D,L‐lactide‐co‐glycolide)] hydrogels , 2007 .

[62]  Ruth Duncan,et al.  Radioiodination of Alginate via Covalently-Bound Tyrosinamide Allows Monitoring of its Fate In Vivo , 1995 .

[63]  Eben Alsberg,et al.  Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[64]  Kevin Braeckmans,et al.  Protein‐Release Behavior of Self‐Assembled PEG–β‐Cyclodextrin/PEG–Cholesterol Hydrogels , 2009 .

[65]  Luke G Green,et al.  A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. , 2002, Angewandte Chemie.

[66]  David J Mooney,et al.  Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensions. , 2007, Biomaterials.

[67]  M. Shoichet,et al.  Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning. , 2011, Bioconjugate chemistry.

[68]  J. Davies,et al.  Molecular Biology of the Cell , 1983, Bristol Medico-Chirurgical Journal.

[69]  S. Andreadis,et al.  A novel role of fibrin in epidermal healing: plasminogen-mediated migration and selective detachment of differentiated keratinocytes. , 2003, The Journal of investigative dermatology.

[70]  C. Neinhuis,et al.  Minimal peptide motif for non-covalent peptide-heparin hydrogels. , 2013, Journal of the American Chemical Society.

[71]  Joseph D. Andrade,et al.  Protein—surface interactions in the presence of polyethylene oxide , 1991 .

[72]  J. Kobler,et al.  Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. , 2006, Biomacromolecules.

[73]  F. Andreopoulos,et al.  Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds. , 2006, Biomaterials.

[74]  Kristi S. Anseth,et al.  A Versatile Synthetic Extracellular Matrix Mimic via Thiol‐Norbornene Photopolymerization , 2009, Advanced materials.

[75]  H. Allcock Polyphosphazene Elastomers, Gels, and Other Soft Materials. , 2012, Soft matter.

[76]  T. Jozefiak,et al.  Free radical polymerization of poly(ethylene glycol) diacrylate macromers: impact of macromer hydrophobicity and initiator chemistry on polymerization efficiency. , 2011, Acta biomaterialia.

[77]  Sang Young Lee,et al.  Thermosensitive chitosan-Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration. , 2009, Acta biomaterialia.

[78]  S. Bryant,et al.  Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels. , 2011, Acta biomaterialia.

[79]  T. Segura,et al.  DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells. , 2009, Biomaterials.

[80]  Kinam Park,et al.  Biomedical Applications of Hydrogels Handbook , 2010 .

[81]  Alan J. Man,et al.  Neurite outgrowth in fibrin gels is regulated by substrate stiffness. , 2011, Tissue engineering. Part A.

[82]  Lin Yu,et al.  Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion. , 2011, Biomaterials.

[83]  M. Longaker,et al.  Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing. , 2011, Tissue engineering. Part A.

[84]  J. Turnbull,et al.  Heparan sulfate: decoding a dynamic multifunctional cell regulator. , 2001, Trends in cell biology.

[85]  Kristi S Anseth,et al.  Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function. , 2009, Journal of biomedical materials research. Part A.

[86]  J. Burdick,et al.  Stem Cell Response to Spatially and Temporally Displayed and Reversible Surface Topography , 2013, Advanced healthcare materials.

[87]  Daniel A Fletcher,et al.  Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures , 2006, Science.

[88]  Craig J. Hawker,et al.  The power of thiol‐ene chemistry , 2010 .

[89]  Kelly M Schultz,et al.  Gelation of Covalently Cross-Linked PEG-Heparin Hydrogels. , 2009, Macromolecules.

[90]  David L Kaplan,et al.  A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects. , 2012, Journal of the mechanical behavior of biomedical materials.

[91]  J. Suh,et al.  Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. , 2000, Biomaterials.

[92]  Kristi S. Anseth,et al.  The effect of bioactive hydrogels on the secretion of extracellular matrix molecules by valvular interstitial cells. , 2008, Biomaterials.

[93]  Kristi S Anseth,et al.  Cell–cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function , 2011, Proceedings of the National Academy of Sciences.

[94]  Jiguang Liu,et al.  pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel. , 2011, International journal of pharmaceutics.

[95]  Johnathan N. Brantley,et al.  Unclicking the Click: Mechanically Facilitated 1,3-Dipolar Cycloreversions , 2011, Science.

[96]  Jason A. Burdick,et al.  Sequential crosslinking to control cellular spreading in 3-dimensional hydrogels , 2009 .

[97]  Michael C. Giano,et al.  Controlled biodegradation of self-assembling β-hairpin peptide hydrogels by proteolysis with matrix metalloproteinase-13. , 2011, Biomaterials.

[98]  Shaoyu Lü,et al.  An injectable oxidized carboxymethylcellulose/N-succinyl-chitosan hydrogel system for protein delivery , 2010 .

[99]  W. Wurst,et al.  EphA-Ephrin-A-Mediated β Cell Communication Regulates Insulin Secretion from Pancreatic Islets , 2007, Cell.

[100]  R. Franco,et al.  The central role of glutathione in the pathophysiology of human diseases , 2007, Archives of physiology and biochemistry.

[101]  Adah Almutairi,et al.  Low power, biologically benign NIR light triggers polymer disassembly. , 2011, Macromolecules.

[102]  Xiaoyi Wang,et al.  HYAL1 overexpression is correlated with the malignant behavior of human breast cancer , 2011, International journal of cancer.

[103]  C. Tanford Macromolecules , 1994, Nature.

[104]  Kenneth M. Yamada,et al.  Cell–matrix adhesion , 2007, Journal of cellular physiology.

[105]  Jason A Burdick,et al.  Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures. , 2008, Biomacromolecules.

[106]  Carolyn R Bertozzi,et al.  Cu-free click cycloaddition reactions in chemical biology. , 2010, Chemical Society reviews.

[107]  Adam J Engler,et al.  Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro. , 2011, Biomaterials.

[108]  David J Mooney,et al.  Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. , 2005, Biomaterials.

[109]  Kristi S. Anseth,et al.  Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties Through Orthogonal Photoconjugation and Photocleavage Reactions , 2011, Nature chemistry.

[110]  A. Andrianov Polyphosphazenes for Biomedical Applications , 2009 .

[111]  Krzysztof Matyjaszewski,et al.  Influence of the degree of methacrylation on hyaluronic acid hydrogels properties. , 2008, Biomaterials.

[112]  Matthias P Lutolf,et al.  The effect of matrix characteristics on fibroblast proliferation in 3D gels. , 2010, Biomaterials.

[113]  I. I. Kurochkin,et al.  Study of cryostructuring of polymer systems: 27. Physicochemical properties of poly(vinyl alcohol) cryogels and specific features of their macroporous morphology , 2007 .

[114]  Kristi S. Anseth,et al.  Photodegradable, Photoadaptable Hydrogels via Radical-Mediated Disulfide Fragmentation Reaction , 2011, Macromolecules.

[115]  R. Barbucci Hydrogels : biological properties and applications , 2009 .

[116]  M. Shokrgozar,et al.  Preparation and characterization of polyvinyl alcohol hydrogels crosslinked by biodegradable polyurethane for tissue engineering of cartilage , 2010 .

[117]  S. Kharb Toxicology , 1936 .

[118]  Adam J. Engler,et al.  Myotubes differentiate optimally on substrates with tissue-like stiffness , 2004, The Journal of cell biology.

[119]  J. Hubbell,et al.  Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. , 2010, Biomaterials.

[120]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[121]  T. Segura,et al.  Biocompatible hydrogels by oxime Click chemistry. , 2012, Biomacromolecules.

[122]  R. Liddington,et al.  Integrin activation takes shape , 2002, The Journal of cell biology.

[123]  Robert J Fisher,et al.  Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants. , 2006, Biomaterials.

[124]  E. Kramer,et al.  Tunable, High Modulus Hydrogels Driven by Ionic Coacervation , 2011, Advanced materials.

[125]  A. Zelikin,et al.  Poly(vinyl alcohol) physical hydrogels: new vista on a long serving biomaterial. , 2011, Macromolecular bioscience.

[126]  M. Prabaharan Review Paper: Chitosan Derivatives as Promising Materials for Controlled Drug Delivery , 2008, Journal of biomaterials applications.

[127]  Dean P. Jones,et al.  Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC. , 1998, Clinica chimica acta; international journal of clinical chemistry.

[128]  A. Khademhosseini,et al.  Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology , 2006 .

[129]  Achim Goepferich,et al.  Rational design of hydrogels for tissue engineering: impact of physical factors on cell behavior. , 2007, Biomaterials.

[130]  Klaus D. Jandt,et al.  Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. , 2009, Acta biomaterialia.

[131]  K. J. Grande-Allen,et al.  Review. Hyaluronan: a powerful tissue engineering tool. , 2006, Tissue engineering.

[132]  A. Hoffman,et al.  Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules. , 2007, Biomacromolecules.

[133]  Jason A. Burdick,et al.  Spatially controlled hydrogel mechanics to modulate stem cell interactions , 2010 .

[134]  Aimee L Boyle,et al.  De novo designed peptides for biological applications. , 2011, Chemical Society reviews.

[135]  S. Girois,et al.  Polym. Degrad. Stab. , 1996 .

[136]  David L Kaplan,et al.  Silk–hyaluronan-based composite hydrogels: A novel, securable vehicle for drug delivery , 2013, Journal of biomaterials applications.

[137]  Sang Hoon Lee,et al.  Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. , 2007, Biomaterials.

[138]  Nic D. Leipzig,et al.  Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds. , 2011, Biomaterials.

[139]  Shuguang Zhang,et al.  Slow release of molecules in self-assembling peptide nanofiber scaffold. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[140]  Dong-An Wang,et al.  Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids. , 2010, Advanced drug delivery reviews.

[141]  Woo Seob Kim,et al.  Adipose tissue engineering using injectable, oxidized alginate hydrogels. , 2012, Tissue engineering. Part A.

[142]  C. Bowman,et al.  A Diels-Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells. , 2013, Biomaterials.

[143]  A. Borzacchiello,et al.  Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters. , 2010, Acta biomaterialia.

[144]  Ximeng Sun,et al.  Hybrid alginate beads with thermal‐responsive gates for smart drug delivery , 2011 .

[145]  T. Deming,et al.  Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides , 2010 .

[146]  Dany J. Munoz-Pinto,et al.  Photo-cross-linked PDMSstar-PEG hydrogels: synthesis, characterization, and potential application for tissue engineering scaffolds. , 2010, Biomacromolecules.

[147]  A. Baas,et al.  FDA-approved poly(ethylene glycol)–protein conjugate drugs , 2011 .

[148]  Jennifer L West,et al.  Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration. , 2007, Biomaterials.

[149]  David L Kaplan,et al.  Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicine. , 2009, Seminars in cell & developmental biology.

[150]  Stephanie Bryant,et al.  Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds. , 2008, Biomacromolecules.

[151]  R V Bellamkonda,et al.  Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. , 2007, Biomaterials.

[152]  S. Wereley,et al.  Soft Matter , 2014 .

[153]  Xinqiao Jia,et al.  Resilin-Like Polypeptide Hydrogels Engineered for Versatile Biological Functions. , 2013, Soft matter.

[154]  Andrew D Rouillard,et al.  Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability. , 2011, Tissue engineering. Part C, Methods.

[155]  J. Temenoff,et al.  Differentiation of mesenchymal stem cells in heparin-containing hydrogels via coculture with osteoblasts , 2012, Cell and Tissue Research.

[156]  Matthew S. Rehmann,et al.  Tunable and dynamic soft materials for three-dimensional cell culture , 2013, Soft matter.

[157]  L. Grover,et al.  Cell encapsulation using biopolymer gels for regenerative medicine , 2010, Biotechnology Letters.

[158]  Xinqiao Jia,et al.  Controlling the adhesion and differentiation of mesenchymal stem cells using hyaluronic acid-based, doubly crosslinked networks. , 2011, Biomaterials.

[159]  L. Grover,et al.  Encapsulation of fibroblasts causes accelerated alginate hydrogel degradation. , 2010, Acta biomaterialia.

[160]  Jöns Hilborn,et al.  Poly(vinyl alcohol)-Based Hydrogels Formed by “Click Chemistry” , 2006 .

[161]  C. Bowman,et al.  Development and Characterization of Degradable Thiol-Allyl Ether Photopolymers. , 2007, Polymer.

[162]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[163]  M. Mahoney,et al.  Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation. , 2010, Tissue engineering. Part A.

[164]  K. Kiick,et al.  Reversible maleimide-thiol adducts yield glutathione-sensitive poly(ethylene glycol)-heparin hydrogels. , 2013, Polymer chemistry.

[165]  J. Hedrick,et al.  Synthesis of well-defined hydrogel networks using click chemistry. , 2006, Chemical communications.

[166]  Hui-Juan Chu,et al.  Diels–Alder reaction in water for the straightforward preparation of thermoresponsive hydrogels , 2011 .

[167]  Jennifer Patterson,et al.  Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration. , 2010, Biomaterials.

[168]  M. Hincke,et al.  Fibrin: a versatile scaffold for tissue engineering applications. , 2008, Tissue engineering. Part B, Reviews.

[169]  The synthesis and degradation of collagenase-degradable poly(2-hydroxyethyl methacrylate)-based hydrogels and sponges for potential applications as scaffolds in tissue engineering , 2012 .

[170]  A. Almond Visions and reflections: hyaluronan , 2007 .

[171]  T. Chirila,et al.  Biodegradation of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly{(2-hydroxyethyl methacrylate)-co-[poly(ethylene glycol) methyl ether methacrylate]} hydrogels containing peptide-based cross-linking agents. , 2010, Biomacromolecules.

[172]  L. Poole-Warren,et al.  Degradable, click poly(vinyl alcohol) hydrogels: characterization of degradation and cellular compatibility , 2012, Biomedical materials.

[173]  S. Takeuchi,et al.  Monodisperse Alginate Hydrogel Microbeads for Cell Encapsulation , 2007 .

[174]  D. Kaplan,et al.  Silk-based delivery systems of bioactive molecules. , 2010, Advanced drug delivery reviews.

[175]  Eben Alsberg,et al.  FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[176]  M. Lutolf,et al.  Artificial niche microarrays for probing single stem cell fate in high throughput , 2011, Nature Methods.

[177]  G. Prestwich,et al.  Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. , 2011, Biomaterials.

[178]  Kristi S Anseth,et al.  In situ elasticity modulation with dynamic substrates to direct cell phenotype. , 2010, Biomaterials.

[179]  D. Pochan,et al.  Tuning the pH responsiveness of beta-hairpin peptide folding, self-assembly, and hydrogel material formation. , 2009, Biomacromolecules.

[180]  Thrimoorthy Potta,et al.  Injectable, dual cross-linkable polyphosphazene blend hydrogels. , 2010, Biomaterials.

[181]  Anuvat Sirivat,et al.  Electrically controlled release of sulfosalicylic acid from crosslinked poly(vinyl alcohol) hydrogel. , 2008, International journal of pharmaceutics.

[182]  P. Stayton,et al.  Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium. , 2011, Biomaterials.

[183]  Jiaping Lin,et al.  Dual-drug delivery system based on hydrogel/micelle composites. , 2009, Biomaterials.

[184]  Kristi S. Anseth,et al.  Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture , 2010, Chemistry of materials : a publication of the American Chemical Society.

[185]  C. Werner,et al.  Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[186]  J. Hubbell,et al.  Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. , 2003, Biomacromolecules.

[187]  R. Weissleder,et al.  Tetrazine-based cycloadditions: application to pretargeted live cell imaging. , 2008, Bioconjugate chemistry.

[188]  Shingo Nakamura,et al.  Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. , 2010, Biomaterials.

[189]  Aaron D Baldwin,et al.  Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[190]  K. Marra,et al.  Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. , 2009, Biomaterials.

[191]  R. Zhuo,et al.  Strategies to improve the response rate of thermosensitive hydrogels. , 2008, Soft matter.

[192]  C. Glackin,et al.  Neural Stem Cell Targeting of Glioma Is Dependent on Phosphoinositide 3‐Kinase Signaling , 2008, Stem cells.

[193]  G. Awad,et al.  Physically Cross-Linked Polyvinyl Alcohol for the Topical Delivery of Fluconazole , 2009 .

[194]  M. Shoichet,et al.  Diels-Alder Click cross-linked hyaluronic acid hydrogels for tissue engineering. , 2011, Biomacromolecules.

[195]  Jason A. Burdick,et al.  Engineering ECM signals into biomaterials , 2012 .

[196]  Kelly M. Schultz,et al.  Microrheology of biomaterial hydrogelators , 2012 .

[197]  Elazer R. Edelman,et al.  Adv. Drug Delivery Rev. , 1997 .

[198]  Chun Wang,et al.  Stromal-Derived Factor-1 Alpha-Loaded PLGA Microspheres for Stem Cell Recruitment , 2011, Pharmaceutical Research.

[199]  Srivatsan Raghavan,et al.  Micropatterned dynamically adhesive substrates for cell migration. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[200]  L. Andrew Lyon,et al.  Hydrogel micro and nanoparticles , 2012 .

[201]  Helena N. Chia,et al.  Effect of substrate stiffness on pulmonary fibroblast activation by TGF-β. , 2012, Acta biomaterialia.

[202]  W. Shen,et al.  In situ forming physical hydrogels for three-dimensional tissue morphogenesis. , 2011, Macromolecular bioscience.

[203]  G. Tae,et al.  Modulation of cell adhesion of heparin-based hydrogel by efficient physisorption of adhesive proteins , 2012, Macromolecular Research.

[204]  Kristi S Anseth,et al.  Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial. , 2005, Biomaterials.

[205]  H. Elias Principles of Polymerization , 1977 .

[206]  Jie Song,et al.  Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. , 2011, Chemistry, an Asian journal.

[207]  D. S. Lee,et al.  Sustained delivery of doxorubicin using biodegradable pH/temperature-sensitive poly(ethylene glycol)-poly(β-amino ester urethane) multiblock copolymer hydrogels , 2011 .

[208]  Kristi S. Anseth,et al.  Exogenously triggered, enzymatic degradation of photopolymerized hydrogels with polycaprolactone subunits: experimental observation and modeling of mass loss behavior. , 2006, Biomacromolecules.

[209]  R. Pipkorn,et al.  Inverse‐electron‐demand Diels‐Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells , 2009, Journal of peptide science : an official publication of the European Peptide Society.

[210]  A. Mikos,et al.  Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. , 2009, Biomacromolecules.

[211]  Sujata K. Bhatia,et al.  Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications , 2012 .

[212]  A. Metters,et al.  Network formation and degradation behavior of hydrogels formed by Michael-type addition reactions. , 2005, Biomacromolecules.

[213]  Ping Li,et al.  A novel pH sensitive N‐succinyl chitosan/alginate hydrogel bead for nifedipine delivery , 2008, Biopharmaceutics & drug disposition.

[214]  Chien-Chi Lin,et al.  PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids. , 2011, Biomaterials.

[215]  Andrew McCaskie,et al.  Nanomedicine , 2005, BMJ.

[216]  L. Allen Stem cells. , 2003, The New England journal of medicine.

[217]  S. Zustiak,et al.  Influence of cell-adhesive peptide ligands on poly(ethylene glycol) hydrogel physical, mechanical and transport properties. , 2010, Acta biomaterialia.

[218]  G. Prestwich Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[219]  Panagiotis Argitis,et al.  Photodegradable polymers for biotechnological applications. , 2012, Macromolecular rapid communications.

[220]  Liang Zhao,et al.  An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. , 2010, Biomaterials.

[221]  Murat Guvendiren,et al.  The control of stem cell morphology and differentiation by hydrogel surface wrinkles. , 2010, Biomaterials.

[222]  Long Liu,et al.  Microbial production of hyaluronic acid: current state, challenges, and perspectives , 2011, Microbial cell factories.

[223]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[224]  A. Panitch,et al.  A collagen peptide-based physical hydrogel for cell encapsulation. , 2011, Macromolecular Bioscience.

[225]  L. Shea,et al.  Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[226]  Antonios G Mikos,et al.  2007 AIChE Alpha Chi Sigma Award: From Material to Tissue: Biomaterial Development, Scaffold Fabrication, and Tissue Engineering. , 2008, AIChE journal. American Institute of Chemical Engineers.

[227]  Richard Hoogenboom,et al.  Click chemistry beyond metal-catalyzed cycloaddition. , 2009, Angewandte Chemie.

[228]  Soo-Chang Song,et al.  Doxorubicin-polyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics. , 2009, Biomaterials.

[229]  Jason A Burdick,et al.  Review: photopolymerizable and degradable biomaterials for tissue engineering applications. , 2007, Tissue engineering.

[230]  Glenn D Prestwich,et al.  The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor. , 2010, Biomaterials.

[231]  Yongqiang Shen,et al.  Study on Biological Safety of Polyvinyl Alcohol/Collagen Hydrogel as Tissue Substitute (I) , 2011 .

[232]  Jason A. Burdick,et al.  Hyaluronic Acid Hydrogels for Biomedical Applications , 2011, Advanced materials.

[233]  D. G. T. Strange,et al.  Extracellular-matrix tethering regulates stem-cell fate. , 2012, Nature materials.

[234]  A. Hoffman,et al.  Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[235]  H. Kim,et al.  Collagen three-dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation. , 2012, Tissue engineering. Part A.

[236]  B. Aksak,et al.  Thermoresponsive hydrogel scaffolds with tailored hydrophilic pores. , 2011, Chemistry, an Asian journal.

[237]  Kristi S. Anseth,et al.  Mixed Mode Thiol−Acrylate Photopolymerizations for the Synthesis of PEG−Peptide Hydrogels , 2008 .

[238]  S. Bhatia,et al.  Three-Dimensional Photopatterning of Hydrogels Containing Living Cells , 2002 .

[239]  Christopher N Bowman,et al.  Thiol-ene click chemistry. , 2010, Angewandte Chemie.

[240]  K. Kiick Peptide- and protein-mediated assembly of heparinized hydrogels. , 2008, Soft matter.

[241]  Ali Khademhosseini,et al.  Mechanically robust and bioadhesive collagen and photocrosslinkable hyaluronic acid semi-interpenetrating networks. , 2009, Tissue engineering. Part A.

[242]  April M. Kloxin,et al.  Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus , 2012, PloS one.

[243]  M. Nugent,et al.  Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness. , 2011, Biophysical journal.

[244]  Carolyn R. Bertozzi,et al.  Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry , 2008, Journal of the American Chemical Society.

[245]  M. G. Finn,et al.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions. , 2001, Angewandte Chemie.

[246]  M. Mosesson Fibrinogen and fibrin structure and functions , 2005, Journal of thrombosis and haemostasis : JTH.

[247]  David J Mooney,et al.  Stem-cell differentiation: Anchoring cell-fate cues. , 2012, Nature materials.

[248]  Michael T. Taylor,et al.  Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells. , 2012, Journal of the American Chemical Society.

[249]  P. Martens,et al.  Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering. , 2003, Biomacromolecules.

[250]  Mark W. Tibbitt,et al.  Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D. , 2012, Integrative biology : quantitative biosciences from nano to macro.

[251]  D. Rabenstein Heparin and heparan sulfate: structure and function. , 2002, Natural product reports.

[252]  K. Ishihara,et al.  Spherical phospholipid polymer hydrogels for cell encapsulation prepared with a flow-focusing microfluidic channel device. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[253]  J. Hubbell,et al.  Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis , 2009 .

[254]  A. Sanyal Diels–Alder Cycloaddition‐Cycloreversion: A Powerful Combo in Materials Design , 2010 .

[255]  D. Kohane,et al.  HYDROGELS IN DRUG DELIVERY: PROGRESS AND CHALLENGES , 2008 .

[256]  K. Alexander,et al.  Unfractionated heparin dosing and risk of major bleeding in non-ST-segment elevation acute coronary syndromes. , 2008, American heart journal.

[257]  J. Cui,et al.  Facile preparation of poly(N-isopropylacrylamide)-based hydrogels via aqueous Diels–Alder click reaction , 2010 .

[258]  Kristi S. Anseth,et al.  Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties , 2009, Science.

[259]  Michael Gelinsky,et al.  Novel soft alginate hydrogel strongly supports neurite growth and protects neurons against oxidative stress. , 2012, Tissue engineering. Part A.

[260]  Beatriz Peñalver Bernabé,et al.  The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells. , 2012, Biomaterials.

[261]  Nikolaos A. Peppas,et al.  PREPARATION, STRUCTURE AND DIFFUSIONAL BEHAVIOR OF HYDROGELS IN CONTROLLED RELEASE , 1993 .

[262]  S. Van Vlierberghe,et al.  Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. , 2011, Biomacromolecules.

[263]  Yingyu Zhou,et al.  A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing , 2010 .

[264]  Chien-Chi Lin,et al.  Cross-linking and degradation of step-growth hydrogels formed by thiol-ene photoclick chemistry. , 2012, Biomacromolecules.

[265]  D Seliktar,et al.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. , 2004, Journal of biomedical materials research. Part A.

[266]  Murat Guvendiren,et al.  Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics , 2012, Nature Communications.

[267]  Lewis H Romer,et al.  Focal Adhesions Paradigm for a Signaling Nexus , 2006 .

[268]  Joseph M. Fox,et al.  Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. , 2008, Journal of the American Chemical Society.

[269]  Celeste M Nelson,et al.  Endogenous patterns of mechanical stress are required for branching morphogenesis. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[270]  C. Higginbotham,et al.  Preparation of a novel freeze thawed poly(vinyl alcohol) composite hydrogel for drug delivery applications. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[271]  João Rodrigues,et al.  Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. , 2012, Chemical Society reviews.

[272]  C. M. Alves,et al.  Responsive and in situ-forming chitosan scaffolds for bone tissue engineering applications: an overview of the last decade , 2010 .

[273]  Gianluca Ciardelli,et al.  Collagen for bone tissue regeneration. , 2012, Acta biomaterialia.

[274]  Kristi L Kiick,et al.  Production of heparin-containing hydrogels for modulating cell responses. , 2009, Acta biomaterialia.

[275]  Christian Franck,et al.  Three-Dimensional Traction Force Microscopy: A New Tool for Quantifying Cell-Matrix Interactions , 2011, PloS one.

[276]  Gregory A Hudalla,et al.  An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks. , 2008, Biomacromolecules.

[277]  F. Boschetti,et al.  Effect of in vitro culture on a chondrocyte-fibrin glue hydrogel for cartilage repair , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[278]  D. Schaffer,et al.  Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. , 2007, Biomaterials.

[279]  Angel Ortega,et al.  Glutathione in Cancer Biology and Therapy , 2006, Critical reviews in clinical laboratory sciences.

[280]  Anjana Jain,et al.  Photocrosslinkable chitosan based hydrogels for neural tissue engineering. , 2012, Soft matter.

[281]  Mina J. Bissell,et al.  Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices , 2009, Cancer and Metastasis Reviews.

[282]  G A Petsko,et al.  Chemistry and biology. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[283]  K. V. Van Vliet,et al.  Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. , 2009, Biomaterials.

[284]  Kristi S Anseth,et al.  Controlled two-photon photodegradation of PEG hydrogels to study and manipulate subcellular interactions on soft materials. , 2010, Soft matter.

[285]  Kristi S. Anseth,et al.  PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine , 2009, Pharmaceutical Research.

[286]  Jason A Burdick,et al.  Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels. , 2010, Biomaterials.

[287]  S. Andreadis,et al.  A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation , 2012, Gene Therapy.

[288]  Milan Mrksich,et al.  Geometric cues for directing the differentiation of mesenchymal stem cells , 2010, Proceedings of the National Academy of Sciences.

[289]  P. A. Dimilla,et al.  Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength. , 2009, Biophysical journal.

[290]  R. Misra,et al.  Biomaterials , 2008 .

[291]  Florian Rehfeldt,et al.  Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. , 2012, Integrative biology : quantitative biosciences from nano to macro.

[292]  K. Kiick,et al.  Tunable degradation of maleimide-thiol adducts in reducing environments. , 2011, Bioconjugate chemistry.

[293]  Matthias P. Lutolf,et al.  Designing materials to direct stem-cell fate , 2009, Nature.

[294]  K. Kiick,et al.  Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering. , 2013, Macromolecules.

[295]  R. Langer,et al.  Designing materials for biology and medicine , 2004, Nature.

[296]  Karyn G. Robinson,et al.  Differential effects of substrate modulus on human vascular endothelial, smooth muscle, and fibroblastic cells. , 2012, Journal of biomedical materials research. Part A.

[297]  K. Anseth,et al.  Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. , 2008, Nature materials.

[298]  Hyaluronic Acid-Based Hydrogels Crosslinked by Copper-Catalyzed Azide-Alkyne Cycloaddition with Tailorable Mechanical Properties , 2011, The International journal of artificial organs.

[299]  B. Toole,et al.  Hyaluronan: from extracellular glue to pericellular cue , 2004, Nature Reviews Cancer.

[300]  D. Seliktar Designing Cell-Compatible Hydrogels for Biomedical Applications , 2012, Science.

[301]  L. Schmidt‐Mende,et al.  ZnO - nanostructures, defects, and devices , 2007 .

[302]  Yu-Ling Yin Chitosan-Based Hydrogels : Functions and Applications , 2011 .

[303]  R. Doolittle Fibrinogen and fibrin. , 1984, Annual review of biochemistry.

[304]  Shuguang Zhang,et al.  Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold , 2009, Proceedings of the National Academy of Sciences.

[305]  Kristi S Anseth,et al.  Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation. , 2006, Tissue engineering.

[306]  Barbara Mulloy,et al.  Heparin - A Century of Progress , 2012, Handbook of Experimental Pharmacology.

[307]  R. Lamanna,et al.  Novel hydrogels via click chemistry: synthesis and potential biomedical applications. , 2007, Biomacromolecules.

[308]  Julianne L. Holloway,et al.  Design of semi‐degradable hydrogels based on poly(vinyl alcohol) and poly(lactic‐co‐glycolic acid) for cartilage tissue engineering , 2011, Journal of tissue engineering and regenerative medicine.

[309]  Glenn D Prestwich,et al.  Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2. , 2012, Biomaterials.

[310]  C. van Nostrum,et al.  Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry. , 2010, Biomacromolecules.

[311]  E. Furst,et al.  Growth factor mediated assembly of cell receptor-responsive hydrogels. , 2007, Journal of the American Chemical Society.

[312]  K. Anseth,et al.  Multifunctional Hydrogels that Promote Osteogenic Human Mesenchymal Stem Cell Differentiation Through Stimulation and Sequestering of Bone Morphogenic Protein 2 , 2007 .

[313]  Bradley D Olsen,et al.  Reinforcement of Shear Thinning Protein Hydrogels by Responsive Block Copolymer Self‐Assembly , 2013, Advanced functional materials.

[314]  David J Mooney,et al.  New materials for tissue engineering: towards greater control over the biological response. , 2008, Trends in biotechnology.

[315]  H. Schlaad,et al.  Thio-click modification of poly [2-(3-butenyl)-2-oxazoline] , 2007 .

[316]  A. Jayakrishnan,et al.  Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. , 2005, Biomaterials.

[317]  T. Hoare,et al.  Injectable, mixed natural-synthetic polymer hydrogels with modular properties. , 2012, Biomacromolecules.

[318]  Cindi M Morshead,et al.  Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels. , 2011, Nature materials.

[319]  Jason A. Burdick,et al.  Controlling Stem Cell Fate with Material Design , 2010, Advanced materials.

[320]  A. Suzuki,et al.  A simple method to obtain a swollen PVA gel crosslinked by hydrogen bonds , 2009 .

[321]  R. Tsien,et al.  The Fluorescent Toolbox for Assessing Protein Location and Function , 2006, Science.

[322]  Jay C. Sy,et al.  Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery , 2012, Advanced materials.

[323]  David J Mooney,et al.  Controlled Growth Factor Delivery for Tissue Engineering , 2009, Advanced materials.

[324]  Karyn G. Robinson,et al.  In situ crosslinkable heparin-containing poly(ethylene glycol) hydrogels for sustained anticoagulant release. , 2012, Journal of biomedical materials research. Part A.

[325]  D. Mooney,et al.  Hydrogels for tissue engineering. , 2001, Chemical Reviews.

[326]  Christopher S. Chen,et al.  Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures , 2008, Stem cells.

[327]  A. Kasko,et al.  Photodegradable macromers and hydrogels for live cell encapsulation and release. , 2012, Journal of the American Chemical Society.

[328]  Giuseppe Perale,et al.  Hydrogels in spinal cord injury repair strategies. , 2011, ACS chemical neuroscience.

[329]  Jean-François Lutz,et al.  Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. , 2008, Advanced drug delivery reviews.

[330]  Andreas Bertz,et al.  Encapsulation of proteins in hydrogel carrier systems for controlled drug delivery: influence of network structure and drug size on release rate. , 2013, Journal of biotechnology.

[331]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[332]  F. Chiellini,et al.  Ulvan as a New Type of Biomaterial from Renewable Resources: Functionalization and Hydrogel Preparation , 2010 .

[333]  J A Burdick,et al.  Conversion and temperature profiles during the photoinitiated polymerization of thick orthopaedic biomaterials. , 2001, Biomaterials.

[334]  M. Kurisawa,et al.  An injectable hyaluronic acid-tyramine hydrogel system for protein delivery. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[335]  Kelly M. Schultz,et al.  Measuring the modulus and reverse percolation transition of a degrading hydrogel. , 2012, ACS macro letters.

[336]  J. Mano,et al.  New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/ Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies , 2010 .

[337]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[338]  Robert Stern,et al.  Hyaluronan catabolism: a new metabolic pathway. , 2004, European journal of cell biology.

[339]  A. Khademhosseini,et al.  Hydrogels in Regenerative Medicine , 2009, Advanced materials.

[340]  K. Anseth,et al.  Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery. , 2009, Biomaterials.

[341]  Kristi S Anseth,et al.  The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. , 2011, Biomaterials.

[342]  N. Sahiner,et al.  Hyaluronic acid hydrogel particles with tunable charges as potential drug delivery devices , 2011 .

[343]  Gianfranco Pasut,et al.  PEG conjugates in clinical development or use as anticancer agents: an overview. , 2009, Advanced drug delivery reviews.

[344]  A. Lowe,et al.  Thiol-ene “click” reactions and recent applications in polymer and materials synthesis , 2010 .

[345]  Esther Novosel,et al.  Vascularization is the key challenge in tissue engineering. , 2011, Advanced drug delivery reviews.

[346]  A. Greinacher,et al.  Heparin-Induced Thrombocytopenia: Frequency and Pathogenesis , 2006, Pathophysiology of Haemostasis and Thrombosis.

[347]  Alexander Revzin,et al.  Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes. , 2010, Biomaterials.

[348]  Claudia Fruijtier-Pölloth Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. , 2005, Toxicology.

[349]  T. Hefferan,et al.  Potential of hydrogels based on poly(ethylene glycol) and sebacic acid as orthopedic tissue engineering scaffolds. , 2009, Tissue engineering. Part A.

[350]  N. Wagner,et al.  The effect of protein structure on their controlled release from an injectable peptide hydrogel. , 2010, Biomaterials.

[351]  M. Tang,et al.  Human embryonic stem cell encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering. , 2012, Acta biomaterialia.

[352]  Yi Yan Yang,et al.  Biodegradable poly(ethylene glycol)-peptide hydrogels with well-defined structure and properties for cell delivery. , 2009, Biomaterials.

[353]  A. Barbetta,et al.  Influence of dialkyne structure on the properties of new click-gels based on hyaluronic acid. , 2009, International journal of pharmaceutics.

[354]  J. Weidner Drug delivery. , 2001, Drug discovery today.

[355]  C. Kolodziej,et al.  Dual Click reactions to micropattern proteins , 2011 .

[356]  Charles A. Hales,et al.  Chemistry and biology of hyaluronan , 2004 .

[357]  Xinqiao Jia,et al.  Heparin-decorated, hyaluronic acid-based hydrogel particles for the controlled release of bone morphogenetic protein 2. , 2011, Acta biomaterialia.

[358]  Tatiana Segura,et al.  The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. , 2011, Biomaterials.

[359]  Robert Langer,et al.  Cell-responsive hydrogel for encapsulation of vascular cells. , 2009, Biomaterials.

[360]  J. Moses,et al.  The growing applications of click chemistry. , 2007, Chemical Society reviews.

[361]  K. Matyjaszewski,et al.  Hydrogels by atom transfer radical polymerization. I. Poly(N-vinylpyrrolidinone-g-styrene) via the macromonomer method , 1998 .

[362]  Kristi S Anseth,et al.  Light activated cell migration in synthetic extracellular matrices. , 2012, Biomaterials.

[363]  J. Nie,et al.  Photopolymerized water-soluble chitosan-based hydrogel as potential use in tissue engineering. , 2011, International journal of biological macromolecules.

[364]  Anthony Atala,et al.  Evaluation of hydrogels for bio-printing applications. , 2013, Journal of biomedical materials research. Part A.

[365]  Kee D. Kim,et al.  Polyethylene Glycol Hydrogel Spinal Sealant (DuraSeal Spinal Sealant) as an Adjunct to Sutured Dural Repair in the Spine: Results of a Prospective, Multicenter, Randomized Controlled Study , 2011, Spine.

[366]  M. Finn,et al.  Click chemistry: function follows form. , 2010, Chemical Society reviews.

[367]  L. Poole-Warren,et al.  Structural and functional characterisation of poly(vinyl alcohol) and heparin hydrogels. , 2008, Biomaterials.

[368]  K. Anseth,et al.  Sequential Click Reactions for Synthesizing and Patterning 3D Cell Microenvironments , 2009, Nature materials.

[369]  Colin K. Choi,et al.  Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. , 2010, Trends in cell biology.

[370]  Cloward Dowel,et al.  SPINE , 1995, Bone & Joint 360.

[371]  Mingzhu Liu,et al.  Preparation and controlled degradation of oxidized sodium alginate hydrogel , 2009 .

[372]  Robert E. Gerszten,et al.  Vascular effects of a low-carbohydrate high-protein diet , 2009, Proceedings of the National Academy of Sciences.

[373]  J. Rubin,et al.  Novel multiarm PEG-based hydrogels for tissue engineering. , 2009, Journal of biomedical materials research. Part A.

[374]  A. Dondoni The emergence of thiol-ene coupling as a click process for materials and bioorganic chemistry. , 2008, Angewandte Chemie.

[375]  Mi Zhou,et al.  Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells. , 2009, Biomaterials.

[376]  Claire Yu,et al.  Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair. , 2012, Biomacromolecules.

[377]  X. Wen,et al.  Manipulating neural-stem-cell mobilization and migration in vitro. , 2012, Acta biomaterialia.

[378]  Miqin Zhang,et al.  Chitosan-based hydrogels for controlled, localized drug delivery. , 2010, Advanced drug delivery reviews.

[379]  R. Lal,et al.  Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. , 2011, Biomaterials.

[380]  David L Kaplan,et al.  Silk fibroin biomaterials for controlled release drug delivery , 2011, Expert opinion on drug delivery.

[381]  Seung Jin Lee,et al.  The effect of spacer arm length of an adhesion ligand coupled to an alginate gel on the control of fibroblast phenotype. , 2010, Biomaterials.

[382]  C. T. Buckley,et al.  A growth factor delivery system for chondrogenic induction of infrapatellar fat pad‐derived stem cells in fibrin hydrogels , 2011, Biotechnology and applied biochemistry.

[383]  Kristi S Anseth,et al.  Tunable Hydrogels for External Manipulation of Cellular Microenvironments through Controlled Photodegradation , 2010, Advanced materials.

[384]  Rashid Bashir,et al.  Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation. , 2010, Lab on a chip.