Multiple Roles of G Proteins in Coupling of Receptors to Ionic Channels and Other Effectors

[1]  David Y. Thomas,et al.  The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein , 1989, Cell.

[2]  A. Brown,et al.  Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. , 1989, Science.

[3]  A. Brown,et al.  Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels. , 1989, The Journal of biological chemistry.

[4]  R. Iyengar,et al.  The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits , 1988, Nature.

[5]  A. VanDongen,et al.  Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. , 1988, Science.

[6]  J. Hurley,et al.  Cloning of a Drosophila melanogaster guanine nucleotide regulatory protein beta-subunit gene and characterization of its expression during development. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Brown,et al.  Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers. , 1988, The American journal of physiology.

[8]  D. E. Somers,et al.  A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae. , 1988, The Journal of biological chemistry.

[9]  A. Brown,et al.  A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels. , 1988, Science.

[10]  D. Clapham,et al.  Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[11]  M. Matsuoka,et al.  Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A. Brown,et al.  The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist. , 1988, The Journal of biological chemistry.

[13]  M. Simon,et al.  G protein multiplicity in eukaryotic signal transduction systems. , 1988, Biochemistry.

[14]  G. Isenberg,et al.  The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium. , 1988, Science.

[15]  A. Brown,et al.  Alpha-subunit of Gk activates atrial K+ channels of chick, rat, and guinea pig. , 1988, The American journal of physiology.

[16]  J. Seidman,et al.  Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[17]  G. Schultz,et al.  Cyclic AMP‐independent, dual regulation of voltage‐dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line. , 1988, The EMBO journal.

[18]  R. Toyama,et al.  Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. , 1988, The Journal of biological chemistry.

[19]  R. Cook,et al.  Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels. , 1988, The Journal of biological chemistry.

[20]  R. Miller,et al.  Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. Simon,et al.  Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Y. Kaziro,et al.  Isolation and characterization of the human Gs alpha gene. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A. Brown,et al.  Direct G protein gating of ion channels. , 1988, The American journal of physiology.

[24]  K. Arai,et al.  Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[25]  G. Schultz,et al.  Angiotensin II‐induced stimulation of voltage‐dependent Ca2+ currents in an adrenal cortical cell line. , 1988, The EMBO journal.

[26]  M. Tota,et al.  Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. , 1987, Biochemistry.

[27]  M. Entman,et al.  G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins. , 1987, Archives of biochemistry and biophysics.

[28]  A. Brown,et al.  A G protein directly regulates mammalian cardiac calcium channels. , 1987, Science.

[29]  C. Richardson,et al.  Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. , 1987, The Journal of biological chemistry.

[30]  C. Wilson,et al.  A small multigene family encodes Gi signal-transduction proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[31]  A. Ashkenazi,et al.  An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. , 1987, Science.

[32]  D. T. Jones,et al.  Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. , 1987, The Journal of biological chemistry.

[33]  J. Kurjan,et al.  The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway , 1987, Cell.

[34]  K. Arai,et al.  GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction , 1987, Cell.

[35]  A. Gilman,et al.  A second form of the beta subunit of signal-transducing G proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[36]  P. Casey,et al.  Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. , 1987, The Journal of biological chemistry.

[37]  W. Suki,et al.  The human genome encodes at least three non‐allellic G proteins with αi‐type subunits , 1987 .

[38]  M. Nirenberg,et al.  Human cDNA clones for an alpha subunit of Gi signal-transduction protein. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[39]  R. Snyderman,et al.  Molecular cloning of a new human G protein Evidence for two Giα‐like protein families , 1987 .

[40]  B. Birren,et al.  Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[41]  A. Brown,et al.  Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its α‐subunit , 1987 .

[42]  J. Moss,et al.  Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A. Brown,et al.  The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. , 1987, Science.

[44]  A. Brown,et al.  Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes. , 1987, Molecular endocrinology.

[45]  M. Nakafuku,et al.  Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[46]  G. Schultz,et al.  The GTP-binding protein, Go9 regulates neuronal calcium channels , 1987, Nature.

[47]  R. Snyderman,et al.  Human Gi protein α‐subunit: deduction of amino acid structure from a cloned cDNA , 1987 .

[48]  D. Clapham,et al.  The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart , 1987, Nature.

[49]  A. Gilman,et al.  Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. , 1987, The Journal of biological chemistry.

[50]  A. Brown,et al.  Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk. , 1987, Science.

[51]  M. Nirenberg,et al.  Human cDNA clones for four species of G alpha s signal transduction protein. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A. Luini,et al.  A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[53]  D. Stengel,et al.  β‐Subunits of the human liver Gs/Gi signal‐transducing proteins and those of bovine retinal rod cell transducin are identical , 1986, FEBS letters.

[54]  D. E. Somers,et al.  Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors. , 1986, Science.

[55]  R. Stroud,et al.  Family of G protein α chains: amphipathic analysis and predicted structure of functional domains , 1986 .

[56]  L. Birnbaumer,et al.  Identification by molecular cloning of two forms of the α‐subunit of the human liver stimulatory (Gs) regulatory component of adenylyl cyclase , 1986, FEBS letters.

[57]  H. Bourne,et al.  Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[58]  A. Dolphin,et al.  Regulation of calcium currents by a GTP analogue: Potentiation of (−)-baclofen-mediated inhibition , 1986, Neuroscience Letters.

[59]  A. Gilman,et al.  Molecular basis for two forms of the G protein that stimulates adenylate cyclase. , 1986, The Journal of biological chemistry.

[60]  H. Kawasaki,et al.  Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[61]  R. Doolittle,et al.  Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[62]  K. Kangawa,et al.  Primary structure of the α‐subunit of bovine adenylate cyclase‐inhibiting G‐protein deduced from the cDNA sequence , 1986, FEBS letters.

[63]  D. Russell,et al.  Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[64]  M. Nirenberg,et al.  Detection of alpha-transducin in retinal rods but not cones. , 1986, Science.

[65]  G. Holz,et al.  GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels , 1986, Nature.

[66]  E. Ross,et al.  Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles. , 1986, The Journal of biological chemistry.

[67]  D. Klein,et al.  alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[68]  T. Hirose,et al.  Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence , 1986, FEBS letters.

[69]  J. Moss,et al.  Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site. , 1985, The Journal of biological chemistry.

[70]  E. Hewlett,et al.  ADP-ribosylation of transducin by pertussis toxin. , 1985, The Journal of biological chemistry.

[71]  K. Sugimoto,et al.  Primary structure of the β‐subunit of bovine transducin deduced from the cDNA sequence , 1985, FEBS letters.

[72]  B. Hille,et al.  GTP-binding proteins couple cardiac muscarinic receptors to a K channel , 1985, Nature.

[73]  G. Szabó,et al.  Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue , 1985, Nature.

[74]  F. Jurnak Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins. , 1985, Science.

[75]  A. Gilman,et al.  Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. , 1985, Science.

[76]  P. Seeburg,et al.  Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[77]  H. Khorana,et al.  GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[78]  K. Sugimoto,et al.  Primary structure of the α-subunit of transducin and its relationship to ras proteins , 1985, Nature.

[79]  J. Hurley,et al.  Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. , 1985, Science.

[80]  H. Khorana,et al.  cDNA-derived amino acid sequence of the gamma subunit of GTPase from bovine rod outer segments. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[81]  P. Sternweis,et al.  Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins. , 1985, The Journal of biological chemistry.

[82]  C. Richardson,et al.  A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[83]  L. Birnbaumer,et al.  Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[84]  L. Birnbaumer,et al.  GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases. , 1984, The Journal of biological chemistry.

[85]  C. W. Scott,et al.  Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase. , 1984, Biochemistry.

[86]  M. Simon,et al.  Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[87]  M. Caron,et al.  The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. , 1984, Biochemistry.

[88]  E. Hewlett,et al.  Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase. , 1984, The Journal of biological chemistry.

[89]  H. Bourne,et al.  Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. , 1984, The Journal of biological chemistry.

[90]  H. Lester,et al.  Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[91]  R. Iyengar,et al.  Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[92]  M. Schramm,et al.  Resolution, reconstitution and kinetics of the primary action of a hormone receptor , 1980, Nature.

[93]  R. Iyengar,et al.  Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model. , 1980, The Journal of biological chemistry.

[94]  R. Iyengar,et al.  Hormone receptor-mediated stimulation of adenylyl cyclase systems. Nucleotide effects and analysis in terms of a simple two-state model for the basic receptor-affected enzyme. , 1980, The Journal of biological chemistry.

[95]  F. Eckstein,et al.  Determination of the turn-off reaction for the hormone-activated adenylate cyclase. , 1979, The Journal of biological chemistry.

[96]  W. Zimmerman,et al.  Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments. , 1979, The Journal of biological chemistry.

[97]  H. Bourne,et al.  Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate. , 1979, Molecular pharmacology.

[98]  A. Gilman,et al.  Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. , 1978, The Journal of biological chemistry.

[99]  A. Levitzki,et al.  Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. , 1978, Biochemistry.

[100]  D. Cassel,et al.  Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[101]  L. Birnbaumer,et al.  Adenyl cyclase in fat cells. II. Hormone receptors. , 1969, The Journal of biological chemistry.

[102]  R. Iyengar,et al.  Molecular basis of regulation of ionic channels by G proteins. , 1989, Recent progress in hormone research.

[103]  M. Summers,et al.  Trends in the Development of Baculovirus Expression Vectors , 1988, Bio/Technology.

[104]  Hall Kr Regional homology in GTP-binding proto-oncogene products and elongation factors , 1983 .