Reproducibility of the diagnosis of atypical endometrial hyperplasia

Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of endometrial hyperplasia, the reproducibility of which has been questioned. The Gynecologic Oncology Group (GOG) initiated a protocol to assess the efficacy of hormonal therapy of atypical endometrial hyperplasia (AEH). Primary goals of the first phase (Part A) were to prospectively determine reproducibility of referring institution's pathologist's diagnosis of AEH by a panel of 3 gynecologic pathologists and to determine reproducibility of diagnoses by panel members.

[1]  S. Yamada.  Concurrent Endometrial Carcinoma in Women with a Biopsy Diagnosis of Atypical Endometrial Hyperplasia: A Gynecologic Oncology Group Study , 2007 .

[2]  R. Kurman,et al.  BLAUSTEIN'S PATHOLOGY OF THE FEMALE GENITAL TRACT , 2004 .

[3]  C. Eng,et al.  Molecular identification of latent precancers in histologically normal endometrium. , 2001, Cancer research.

[4]  C. Eng,et al.  Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. , 2000, Journal of the National Cancer Institute.

[5]  G. Mutter,et al.  Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group. , 2000, Gynecologic oncology.

[6]  R M Richart,et al.  Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry , 2000, The Journal of pathology.

[7]  M. Masseroli,et al.  A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. , 1999, The American journal of surgical pathology.

[8]  Kathleen R. Cho,et al.  Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. , 1998, The American journal of surgical pathology.

[9]  B. Skov,et al.  Comparison of the Reproducibility of the WHO Classifications of 1975 and 1994 of Endometrial Hyperplasia , 1997, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[10]  G. Mutter,et al.  Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. , 1996, Cancer research.

[11]  T. Rollason.  Blaustein’s Pathology of the Female Genital Tract , 2003, Springer New York.

[12]  R. Kurman,et al.  The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients , 1986 .

[13]  H. Fox,et al.  The endometrial hyperplasias and their relationship to endometrial neoplasia * , 1982, Histopathology.

[14]  R. Scully.  Definition of endometrial carcinoma precursors. , 1982, Clinical obstetrics and gynecology.

[15]  R. Kempson,et al.  Surgical pathology of the uterine corpus. , 1979, Major problems in pathology.

[16]  F. Tavassoli,et al.  Endometrial lesions in uteri resected for atypical endometrial hyperplasia. , 1978, American journal of clinical pathology.

[17]  F. Vellios.  Endometrial hyperplasias, precursors of endometrial carcinoma. , 1972, Pathology annual.

[18]  S. B. Gusberg.  THE TEACHING HOSPITAL EXPERIENCE. , 1963, American journal of obstetrics and gynecology.

[19]  S. B. Gusberg,et al.  PRECURSORS OF CORPUS CANCER. IV. ADENOMATOUS HYPERPLASIA AS STAGE O CARCINOMA OF THE ENDOMETRIUM. , 1963, American journal of obstetrics and gynecology.

[20]  L. M. Randall,et al.  Precancerous lesions of the endometrium. , 1963, American journal of obstetrics and gynecology.

[21]  P. Campbell,et al.  THE SIGNIFICANCE OF ATYPICAL ENDOMETRIAL HYPERPLASA , 1961 .

[22]  D. Ashley.  CARCINOMA IN SITU OF THE ENDOMETRIUM , 1957, The Journal of obstetrics and gynaecology of the British Empire.

[23]  S. B. Gusberg,et al.  Precursors of corpus cancer. II. A clinical and pathological study of adenomatous hyperplasia. , 1954, American journal of obstetrics and gynecology.