Eukaryotic DNA topoisomerases I.

[1]  K. Kohn,et al.  Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors , 1994 .

[2]  L. Liu,et al.  DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. , 1989, Cancer research.

[3]  H. Nakano,et al.  Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces. , 1990, The Journal of antibiotics.

[4]  R. Hertzberg,et al.  Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. , 1985, The Journal of biological chemistry.

[5]  J. Wang,et al.  Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. , 1980, The Journal of biological chemistry.

[6]  J. Wang Recent studies of DNA topoisomerases. , 1987, Biochimica et biophysica acta.

[7]  Pulleyblank De,et al.  Partial purification of "omega" protein from calf thymus. , 1975 .

[8]  P. Traktman,et al.  Biochemical analysis of mutant alleles of the vaccinia virus topoisomerase I carrying targeted substitutions in a highly conserved domain. , 1993, The Journal of biological chemistry.

[9]  A. McPhail,et al.  Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2 , 1966 .

[10]  J. Champoux,et al.  Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin. , 1992, Cancer research.

[11]  D. Brutlag,et al.  ATP-dependent DNA topoisomerase from D. melanogaster reversibly catenates duplex DNA rings , 1980, Cell.

[12]  E K Rowinsky,et al.  The current status of camptothecin analogues as antitumor agents. , 1993, Journal of the National Cancer Institute.

[13]  R. Sternglanz,et al.  Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. , 1988, Molecular pharmacology.

[14]  J. Wang,et al.  Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin. , 1989, Cancer research.

[15]  Leroy F. Liu [7] HeLa toposiomerase I , 1983 .

[16]  Gerald R. Fink,et al.  Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II , 1988, Cell.

[17]  B. Durkacz,et al.  (ADP-ribose)n participates in DNA excision repair , 1980, Nature.

[18]  C. Yu,et al.  Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. , 1991, Cancer research.

[19]  L. Liu,et al.  Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins. , 1983, Nucleic acids research.

[20]  Y. Tse‐Dinh,et al.  Mutations of vaccinia virus DNA topoisomerase I that stabilize the cleavage complex. , 1994, The Journal of biological chemistry.

[21]  J. Wang,et al.  Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. , 1976, Journal of molecular biology.

[22]  H. Vosberg DNA topoisomerases: enzymes that control DNA conformation. , 1985, Current topics in microbiology and immunology.

[23]  J. Wang,et al.  DNA topoisomerases: why so many? , 1991, The Journal of biological chemistry.

[24]  G. McFadden,et al.  Identification and DNA sequence of the Shope fibroma virus DNA topoisomerase gene. , 1990, Virology.

[25]  S. Shuman Site-specific interaction of vaccinia virus topoisomerase I with duplex DNA. Minimal DNA substrate for strand cleavage in vitro. , 1991, The Journal of biological chemistry.

[26]  I. Pastan,et al.  Expression of Multidrug Resistance Gene in Human Cancers , 1989 .

[27]  K. Kohn,et al.  Effects of DNA methylation on topoisomerase I and II cleavage activities. , 1994, The Journal of biological chemistry.

[28]  D. Kufe,et al.  Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin. , 1994, The Journal of biological chemistry.

[29]  J. Champoux,et al.  The DNA untwisting enzyme from Saccharomyces cerevisiae. Partial purification and characterization. , 1978, The Journal of biological chemistry.

[30]  D. Reinberg,et al.  DNA topoisomerase I is involved in both repression and activation of transcription , 1993, Nature.

[31]  J. Alsner,et al.  Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function. , 1992, The Journal of biological chemistry.

[32]  J. Champoux Mechanism of the reaction catalyzed by the DNA untwisting enzyme: attachment of the enzyme to 3'-terminus of the nicked DNA. , 1978, Journal of molecular biology.

[33]  P. Kroeger,et al.  Analysis of topoisomerase I and II cleavage sites on the Drosophila actin and Hsp70 heat shock genes. , 1992, Biochemistry.

[34]  S. Shuman,et al.  Covalent and noncovalent DNA binding by mutants of vaccinia DNA topoisomerase I. , 1992, The Journal of biological chemistry.

[35]  N. Shimizu,et al.  DNA topoisomerase I phosphorylation in murine fibroblasts treated with 12-O-tetradecanoylphorbol-13-acetate and in vitro by protein kinase. , 1992, The Journal of biological chemistry.

[36]  A. Andersen,et al.  Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination. , 1993, The Journal of biological chemistry.

[37]  J. Wallis,et al.  A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase , 1989, Cell.

[38]  L. Liu,et al.  Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. , 1993, Cancer research.

[39]  U. Mortensen,et al.  Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature. , 1991, Nucleic acids research.

[40]  P. Traktman,et al.  Vaccinia virus encapsidates a novel topoisomerase with the properties of a eucaryotic type I enzyme. , 1987, The Journal of biological chemistry.

[41]  C. Rogler,et al.  Topoisomerase I-mediated integration of hepadnavirus DNA in vitro , 1991, Journal of virology.

[42]  D. Samuels,et al.  Protein kinase C phosphorylates DNA topoisomerase I , 1989, FEBS letters.

[43]  R. Lock,et al.  Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. , 1990, Cancer research.

[44]  D. Boothman,et al.  Down-regulation of topoisomerase I in mammalian cells following ionizing radiation. , 1994, Cancer research.

[45]  O. Westergaard,et al.  A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in tetrahymena R-chromatin , 1985, Cell.

[46]  R. Sternglanz,et al.  Identification of Saccharomyces cerevisiae mutants deficient in DNA topoisomerase I activity. , 1984, The Journal of biological chemistry.

[47]  J. Wang,et al.  Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I. , 1986, Journal of molecular biology.

[48]  E. Di Mauro,et al.  DNA tridimensional context affects the reactivity of eukaryotic DNA topoisomerase I. , 1993, Journal of Molecular Biology.

[49]  H. Nakano,et al.  Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus. , 1991, Biochemistry.

[50]  G. Riou,et al.  A type I DNA topoisomerase from Trypanosoma cruzi. , 1983, European journal of biochemistry.

[51]  D. Lockshon,et al.  Escherichia coli DNA topoisomerase III: purification and characterization of a new type I enzyme. , 1984, Biochemistry.

[52]  J. Lake,et al.  DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote , 1993, Nature.

[53]  C. Bendixen,et al.  Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription. , 1990, Biochemistry.

[54]  L. Liu,et al.  Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity. , 1989, The Journal of biological chemistry.

[55]  Y. Tse‐Dinh,et al.  Conditional growth of Escherichia coli caused by expression of vaccinia virus DNA topoisomerase I , 1992, Journal of bacteriology.

[56]  L. Grochow,et al.  Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. , 1992, Cancer research.

[57]  Y. Pommier,et al.  Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials. , 1993, Molecular pharmacology.

[58]  A. Richter,et al.  Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells. , 1990, Nucleic acids research.

[59]  L. Hartwell,et al.  The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. , 1988, Science.

[60]  C. Rogler,et al.  Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration , 1989, Journal of virology.

[61]  H. Blöcker,et al.  Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin. , 1987, The EMBO journal.

[62]  Y. Pommier,et al.  DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators. , 1987, Nucleic acids research.

[63]  H. Strutt,et al.  Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA. , 1991, Nucleic acids research.

[64]  R. Tobey Effects of cytosine arabinoside, daunomycin, mithramycin, azacytidine, adriamycin, and camptothecin on mammalian cell cycle traverse. , 1972, Cancer research.

[65]  S. Crooke,et al.  Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells. , 1987, Cancer research.

[66]  M. Klein,et al.  Structural characterization of the human DNA topoisomerase I gene promoter. , 1990, European journal of biochemistry.

[67]  R. Knippers,et al.  The promoter region of the human type-I-DNA-topoisomerase gene. Protein-binding sites and sequences involved in transcriptional regulation. , 1993, European journal of biochemistry.

[68]  J. M. Murcia,et al.  Poly(ADP-ribose) polymerase: a molecular nick-sensor. , 1994, Trends in biochemical sciences.

[69]  M. Malanga,et al.  Poly(ADP-ribose) molecules formed during DNA repair in vivo. , 1994, The Journal of biological chemistry.

[70]  Y. Pommier,et al.  Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. , 1993, Experimental cell research.

[71]  K W Kohn,et al.  Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. , 1991, The Journal of biological chemistry.

[72]  S. Shuman Two classes of DNA end-joining reactions catalyzed by vaccinia topoisomerase I. , 1992, The Journal of biological chemistry.

[73]  T. Boulikas Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review). , 1991, Anticancer research.

[74]  T. Andoh,et al.  Characterization of a camptothecin-resistant human DNA topoisomerase I in an in vitro system for Simian virus 40 DNA replication. , 1991, European journal of biochemistry.

[75]  Y. Pommier,et al.  Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. , 1994, The Journal of biological chemistry.

[76]  M. Turman,et al.  A casein kinase type II (CKII)-like nuclear protein kinase associates with, phosphorylates, and activates topoisomerase I. , 1993, Biochemical medicine and metabolic biology.

[77]  G. Brun,et al.  DNA topoisomerase I from mitochondria of Xenopus laevis oocytes. , 2005, European journal of biochemistry.

[78]  R. Hertzberg,et al.  Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content. , 1992, Oncology research.

[79]  R. Knippers,et al.  Structure of the human type I DNA topoisomerase gene. , 1991, The Journal of biological chemistry.

[80]  L. Liu,et al.  DNA topoisomerase poisons as antitumor drugs. , 1989, Annual review of biochemistry.

[81]  T. Andoh,et al.  Cloning of the mouse cDNA encoding DNA topoisomerase I and chromosomal location of the gene. , 1993, Gene.

[82]  G. Riou,et al.  Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation. , 1993, Biochemical pharmacology.

[83]  J. K. Park,et al.  Inhibition of topoisomerase I by NAD and enhancement of cytotoxicity of MMS by inhibitors of poly(ADP-ribose) polymerase in Saccharomyces cerevisiae. , 1991, Cellular and molecular biology.

[84]  E. Durban,et al.  Phosphorylation of human topoisomerase I by protein kinase C in vitro and in phorbol 12-myristate 13-acetate-activated HL-60 promyelocytic leukaemia cells. , 1993, The Biochemical journal.

[85]  J. Wang,et al.  Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. , 1978, The Journal of biological chemistry.

[86]  S. Chatterjee,et al.  Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability. , 1989, Experimental cell research.

[87]  J. Champoux,et al.  Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing. , 1984, Journal of molecular biology.

[88]  Y. Shimizu,et al.  Phosphorylation of DNA topoisomerase I is increased during the response of mammalian cells to mitogenic stimuli. , 1994, Biochimica et biophysica acta.

[89]  J. Champoux,et al.  Mapping in vivo topoisomerase I sites on simian virus 40 DNA: asymmetric distribution of sites on replicating molecules , 1989, Molecular and cellular biology.

[90]  J. Wang,et al.  Transcription and DNA supercoiling. , 1993, Current opinion in genetics & development.

[91]  A. Lu,et al.  Mammalian topoisomerase I has base mismatch nicking activity. , 1994, The Journal of biological chemistry.

[92]  G. Schütz,et al.  Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene , 1987, Cell.

[93]  R. Hertzberg,et al.  On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. , 1989, Biochemistry.

[94]  K. Kohn,et al.  Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin. , 1990, Nucleic acids research.

[95]  Y. Pommier,et al.  Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. , 1995, Cancer research.

[96]  T. Tsuruo,et al.  Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. , 1990, Cancer research.

[97]  R. A. Kim,et al.  A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings , 1989, Cell.

[98]  J. Champoux DNA is linked to the rat liver DNA nicking-closing enzyme by a phosphodiester bond to tyrosine. , 1981, The Journal of biological chemistry.

[99]  C. Perez-stable,et al.  Enrichment and depletion of Hela topoisomerase I recognition sites among specific types of DNA elements. , 1988, Nucleic acids research.

[100]  G. Fink,et al.  A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest. , 1993, Genetics.

[101]  S. Shuman,et al.  Phenotypic selection and characterization of mutant alleles of a eukaryotic DNA topoisomerase I. , 1990, Genes & development.

[102]  Y. Pommier,et al.  Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance. , 1993, The Journal of biological chemistry.

[103]  R. Zucker,et al.  A new action for topoisomerase inhibitors. , 1991, Chemico-biological interactions.

[104]  L. Liu,et al.  DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. , 1989, Science.

[105]  S. Elgin,et al.  Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin , 1987, Molecular and cellular biology.

[106]  M. Duguet,et al.  Gene expression in regenerating liver in relation to cell proliferation and stress. , 1989, European journal of biochemistry.

[107]  R. Knippers,et al.  Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks , 1988, Molecular and cellular biology.

[108]  M. Goodenough,et al.  Topoisomerase I phosphorylation in vitro and in rapidly growing Novikoff hepatoma cells. , 1985, The EMBO journal.

[109]  T. Hsieh,et al.  Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster. , 1983, The Journal of biological chemistry.

[110]  N. Saijo,et al.  Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line. , 1992, Biochemical and biophysical research communications.

[111]  John T. Lis,et al.  Topoisomerase I interacts with transcribed regions in Drosophila cells , 1986, Cell.

[112]  K. Kohn,et al.  Topoisomerase I interaction with SV40 DNA in the presence and absence of camptothecin. , 1988, Nucleic acids research.

[113]  M. Duguet,et al.  DNA topoisomerases from rat liver: physiological variations. , 1983, Nucleic acids research.

[114]  J. Lake,et al.  Purification and characterization of DNA topoisomerase V. An enzyme from the hyperthermophilic prokaryote Methanopyrus kandleri that resembles eukaryotic topoisomerase I. , 1994, The Journal of biological chemistry.

[115]  J. Wang,et al.  Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine. , 1993, Cancer research.

[116]  Eric Patterson,et al.  Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites , 1991, Nucleic Acids Res..

[117]  M. Bjornsti,et al.  Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. , 1993, The Journal of biological chemistry.

[118]  J. Wang,et al.  Interaction between DNA and an Escherichia coli protein omega. , 1971, Journal of molecular biology.

[119]  D. Morris,et al.  Differential modulation by spermidine of reactions catalyzed by type 1 prokaryotic and eukaryotic topoisomerases. , 1985, Biochemistry.

[120]  M. Botchan,et al.  Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination. , 1985, Science.

[121]  O. Westergaard,et al.  Characterization of intra- and intermolecular DNA ligation mediated by eukaryotic topoisomerase I. Role of bipartite DNA interaction in the ligation process. , 1994, The Journal of biological chemistry.

[122]  K W Kohn,et al.  Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin. , 1993, Nucleic acids research.

[123]  J. Riou,et al.  Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives. , 1991, Molecular pharmacology.

[124]  P. Kroeger,et al.  Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock gene. , 1989, Nucleic acids research.

[125]  K. Kohn,et al.  Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm. , 1993, Biochemistry.

[126]  R. Lock,et al.  Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells. , 1990, Cancer research.

[127]  Y. Tse‐Dinh,et al.  Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro , 1984, Nature.

[128]  J. Hwang,et al.  Phorbol ester transiently increases topoisomerase I mRNA levels in human skin fibroblasts. , 1989, The Journal of biological chemistry.

[129]  B. Alberts,et al.  Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. , 1984, The Journal of biological chemistry.

[130]  R. Snapka,et al.  Exposure to camptothecin breaks leading and lagging strand simian virus 40 DNA replication forks. , 1990, Biochemical and biophysical research communications.

[131]  Y. Tse‐Dinh,et al.  An engineered mutant of vaccinia virus DNA topoisomerase I is sensitive to the anti-cancer drug camptothecin. , 1992, The Journal of biological chemistry.

[132]  T. Uemura,et al.  Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and effect of gene disruption. , 1987, Nucleic acids research.

[133]  K. Kohn,et al.  Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I. , 1989, Cancer research.

[134]  H. Busch,et al.  Phosphorylation of purified Novikoff hepatoma topoisomerase I. , 1983, Biochemical and biophysical research communications.

[135]  K. Kohn,et al.  Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II. , 1990, Molecular pharmacology.

[136]  M. Mattern,et al.  Nonproductive rearrangement of DNA topoisomerase I and II genes: correlation with resistance to topoisomerase inhibitors. , 1989, Journal of the National Cancer Institute.

[137]  A. Kikuchi,et al.  Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA , 1984, Nature.

[138]  A. Amadei,et al.  In vitro preferential topoisomerization of bent DNA. , 1989, Nucleic acids research.

[139]  A. Richter,et al.  Expression of the topoisomerase I gene in serum stimulated human fibroblasts. , 1990, Biochimica et biophysica acta.

[140]  Y. Tse‐Dinh,et al.  Mechanistic study of E. coli DNA topoisomerase I: cleavage of oligonucleotides. , 1983, Nucleic acids research.

[141]  R. Herrera,et al.  Rapid induction of c-fos transcription reveals quantitative linkage of RNA polymerase II and DNA topoisomerase I enzyme activities , 1990, Cell.

[142]  R. Sternglanz,et al.  Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I. , 1989, The Journal of biological chemistry.

[143]  W. G. Kelly,et al.  Purification and characterization of a type I DNA topoisomerase from calf thymus mitochondria. , 1987, Biochemistry.