Irs1 serine 307 promotes insulin sensitivity in mice.
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M. White | K. Copps | Kyle D. Copps | W. Qiu | Nancy J Hançer | Lynn Opare-Ado | C. Walsh
[1] E. Schleicher,et al. Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells. , 2008, Molecular endocrinology.
[2] G. Shulman,et al. Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle , 2008, Diabetes.
[3] R. DePinho,et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. , 2008, Cell metabolism.
[4] M. Serrano-Ríos,et al. Molecular basis of insulin action. , 2007, Drug news & perspectives.
[5] M. White,et al. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. , 2007, Molecular endocrinology.
[6] X. Papademetris,et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome , 2007, Proceedings of the National Academy of Sciences.
[7] C. Flynn,et al. Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle , 2007, Diabetes.
[8] K. Petersen,et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. , 2005, The Journal of clinical investigation.
[9] Y. Zick,et al. Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance , 2005, Science's STKE.
[10] T. Hunter,et al. Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.
[11] Dan R. Littman,et al. PKC-θ knockout mice are protected from fat-induced insulin resistance , 2004 .
[12] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[13] I. Gout,et al. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins , 2004, The Journal of cell biology.
[14] Ying Leng,et al. Insulin Signaling Defects in Type 2 Diabetes , 2004, Reviews in Endocrine and Metabolic Disorders.
[15] G. Shulman,et al. PKC-theta knockout mice are protected from fat-induced insulin resistance. , 2004, The Journal of clinical investigation.
[16] F. Haj,et al. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. , 2004, Diabetes.
[17] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[18] Michael Karin,et al. A central role for JNK in obesity and insulin resistance , 2002, Nature.
[19] D. S. Worrall,et al. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. , 2002, The Journal of clinical endocrinology and metabolism.
[20] Roger Davis,et al. The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 * , 2000, The Journal of Biological Chemistry.
[21] C. Kahn,et al. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells , 1997, Molecular and cellular biology.
[22] M. Feinglos,et al. Diet-Induced Type II Diabetes in C57BL/6J Mice , 1988, Diabetes.