Biodegradable elastomers in drug delivery

Background: Biodegradable elastomers have been used in many different manners for controlled drug delivery. The development of new biodegradable elastomers has recently increased, driven mainly by tissue engineering research. Objective: This review outlines the different uses of biodegradable elastomers in controlled release. Methods: This review was limited to those papers wherein the polymer chosen as the delivery vehicle was demonstrably elastomeric. Conclusion: Biodegradable elastomers have an established role in controlled release and an expanding role in combination scaffolds providing controlled release and mechanical stimulation capability for tissue regeneration/engineering.

[1]  G L Kimmel,et al.  Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (epsilon-caprolactone), and their copolymers in vivo. , 1981, Biomaterials.

[2]  F. Gu,et al.  Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[3]  Y. Ikada,et al.  In Vitro Evaluation of Sustained Drug Release from Biodegradable Elastomer , 1991, Pharmaceutical Research.

[4]  B. Dahiyat,et al.  Degradable biomaterials with elastomeric characteristics and drug-carrier function , 1995 .

[5]  B. Amsden.  A model for osmotic pressure driven release from cylindrical rubbery polymer matrices. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[6]  A. Albertsson,et al.  Resilient bioresorbable copolymers based on trimethylene carbonate, L-lactide, and 1,5-dioxepan-2-one. , 2006, Biomacromolecules.

[7]  F. Gu,et al.  Sustained interferon-gamma delivery from a photocrosslinked biodegradable elastomer. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[8]  D. Williams,et al.  Biodegradation of surgical polymers , 1982 .

[9]  J. Kasperczyk,et al.  Controlled Release of 17β-Estradiol from d,l-Lactide/ε-Caprolactone Copolymers , 1996 .

[10]  G. L. Woo,et al.  Biological characterization of a novel biodegradable antimicrobial polymer synthesized with fluoroquinolones. , 2002, Journal of biomedical materials research.

[11]  Joseph M DeSimone,et al.  Amorphous linear aliphatic polyesters for the facile preparation of tunable rapidly degrading elastomeric devices and delivery vectors. , 2006, Journal of the American Chemical Society.

[12]  B. Amsden,et al.  In vivo degradation behavior of photo-cross-linked star-poly(epsilon-caprolactone-co-D,L-lactide) elastomers. , 2006, Biomacromolecules.

[13]  Andreas Lendlein,et al.  Shape-memory polymer networks from oligo[(epsilon-hydroxycaproate)-co-glycolate]dimethacrylates and butyl acrylate with adjustable hydrolytic degradation rate. , 2007, Biomacromolecules.

[14]  R. Lenz,et al.  SPECTROSCOPIC ANALYSIS OF CHAIN CONFORMATION DISTRIBUTION IN A BIODEGRADABLE POLYESTER ELASTOMER, POLY(BETA-HYDROXYOCTANOATE) , 1995 .

[15]  D. Grijpma,et al.  High molecular weight copolymers of l-lactide and ε-caprolactone as biodegradable elastomeric implant materials , 1991 .

[16]  Mohammad K. Hassan,et al.  Biodegradable aliphatic thermoplastic polyurethane based on poly(ε‐caprolactone) and L‐lysine diisocyanate , 2006 .

[17]  J. Feijen,et al.  Copolymers of trimethylene carbonate and ε-caprolactone for porous nerve guides: Synthesis and properties , 2001 .

[18]  Michael S Sacks,et al.  Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly(ester-urethane)ureas based on poly(caprolactone) and putrescine. , 2002, Journal of biomedical materials research.

[19]  J. Seppälä,et al.  Synthesis and Characterization of a Biodegradable Thermoplastic Poly(ester−urethane) Elastomer , 1997 .

[20]  B. Amsden,et al.  Synthesis and Characterization of Thermoset Biodegradable Elastomers Based on Star-Poly(ε-caprolactone-co-d,l-lactide) , 2004 .

[21]  C. G. Pitt.  Poly-ε-caprolactone and its copolymers , 1990 .

[22]  J L Cleland,et al.  Development of poly-(D,L-lactide--coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[23]  Young Ha Kim,et al.  In vivo biocompatibilty and degradation behavior of elastic poly(l-lactide-co-ε-caprolactone) scaffolds , 2004 .

[24]  F. Gu,et al.  Synthesis and characterization of a photo-cross-linked biodegradable elastomer. , 2004, Biomacromolecules.

[25]  A. Schindler,et al.  Sustained drug delivery systems. I. The permeability of poly(ϵ-caprolactone), poly(DL-lactic acid), and their copolymers , 1979 .

[26]  D. Wise,et al.  Assessment of biodegradable controlled release rod systems for pain relief applications , 2002, Journal of biomaterials science. Polymer edition.

[27]  S. Epstein,et al.  Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards. , 2001, Cardiovascular research.

[28]  Jukka Seppälä,et al.  Cross-linked poly(ε-caprolactone/D, L-lactide) copolymers with elastic properties , 2002 .

[29]  R. Bos,et al.  Degradation of and tissue reaction to biodegradable poly(L-lactide) for use as internal fixation of fractures: a study in rats. , 1991, Biomaterials.

[30]  Joseph Kost,et al.  Handbook of Biodegradable Polymers , 1998 .

[31]  A. Albertsson,et al.  Elastomeric hydrolyzable porous scaffolds: copolymers of aliphatic polyesters and a polyether-ester. , 2005, Biomacromolecules.

[32]  A. J. Pennings,et al.  DESIGN AND SYNTHESIS OF BIODEGRADABLE POLY(ESTER-URETHANE) ELASTOMER NETWORKS COMPOSED OF NON-TOXIC BUILDING-BLOCKS , 1988 .

[33]  Robert Langer,et al.  AB-polymer networks based on oligo(epsilon-caprolactone) segments showing shape-memory properties. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Ji‐Heung Kim,et al.  Preparation and Properties of Poly(l-lactide)-block-poly(trimethylenecarbonate) as Biodegradable Thermoplastic Elastomer , 2002 .

[35]  Xiaoyun Liu,et al.  Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks. , 2003, Biomacromolecules.

[36]  F. Sellke,et al.  Therapeutic angiogenesis in cardiology using protein formulations. , 2001, Cardiovascular research.

[37]  J. Koleske,et al.  Lactone Polymerization and Polymer Properties , 1972 .

[38]  B. Amsden.  Curable, biodegradable elastomers: emerging biomaterials for drug delivery and tissue engineering. , 2007, Soft matter.

[39]  Guillermo Antonio Ameer,et al.  Novel Citric Acid‐Based Biodegradable Elastomers for Tissue Engineering , 2004 .

[40]  T. Karjalainen,et al.  Biodegradable lactone copolymers. I: Characterization and mechanical behavior of ε-caprolactone and lactide copolymers , 1996 .

[41]  S. K. Chandrasekaran,et al.  Use of osmotically active therapeutic agents in monolithic systems , 1980 .

[42]  F. Gu,et al.  Sustained interferon-γ delivery from a photocrosslinked biodegradable elastomer , 2005 .

[43]  P. Neuenschwander,et al.  New versatile, elastomeric, degradable polymeric materials for medicine. , 1999, International journal of biological macromolecules.

[44]  Eric J Beckman,et al.  A biodegradable polyurethane-ascorbic acid scaffold for bone tissue engineering. , 2003, Journal of biomedical materials research. Part A.

[45]  A. Lendlein,et al.  Degradable shape-memory polymer networks from oligo[(l-lactide)-ran-glycolide]dimethacrylates. , 2007, Soft matter.

[46]  J. Feijen,et al.  Copolymers of trimethylene carbonate and epsilon-caprolactone for porous nerve guides: synthesis and properties. , 2001, Journal of biomaterials science. Polymer edition.

[47]  J. Benoit,et al.  Biodegradation and brain tissue reaction to poly(D,L-lactide-co-glycolide) microspheres. , 1993, Biomaterials.

[48]  A. Schindler,et al.  The enzymatic surface erosion of aliphatic polyesters , 1984 .

[49]  B. Amsden,et al.  Synthesis, characterization and in vitro degradation of a biodegradable elastomer. , 2004, Biomaterials.

[50]  J. English,et al.  Polyglycolide and polylactide , 1998 .

[51]  R. Schirrer,et al.  Water absorption, swelling, rupture and salt release in salt-silicone rubber compounds , 1992 .

[52]  K. Alitalo,et al.  Gene transfer as a tool to induce therapeutic vascular growth , 2003, Nature Medicine.

[53]  Jian Yang,et al.  Synthesis and evaluation of poly(diol citrate) biodegradable elastomers. , 2006, Biomaterials.

[54]  Y. Tabata,et al.  Sustained-release vancomycin sheet may help to prevent prosthetic graft methicillin-resistant Staphylococcus aureus infection. , 2006, Journal of vascular surgery.

[55]  K. Woodhouse,et al.  Synthesis and characterization of degradable polyurethane elastomers containing and amino acid-based chain extender. , 1998, Journal of biomaterials science. Polymer edition.

[56]  R. Langer,et al.  Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications , 2002, Science.

[57]  F. Gu,et al.  Osmotic-Driven Release Kinetics of Bioactive Therapeutic Proteins from a Biodegradable Elastomer are Linear, Constant, Similar, and Adjustable , 2006, Pharmaceutical Research.

[58]  J. Seppälä,et al.  Miscibility, morphology and mechanical properties of rubber‐modified biodegradable poly(ester‐urethanes) , 2000 .

[59]  D. Williams,et al.  Molecular biointeractions of biomedical polymers with extracellular exudate and inflammatory cells and their effects on the biocompatibility, in vivo. , 1994, Biomaterials.

[60]  G. Poletti,et al.  Poly(lactide-co-glycolide) microspheres containing bupivacaine: comparison between gamma and beta irradiation effects. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[61]  R. Langer,et al.  Biodegradable polymers as drug delivery systems , 1990 .

[62]  S. Huang,et al.  Synthesis and Characterization of Crosslinked Polymers for Biomedical Composites , 1988 .

[63]  R. Langer,et al.  A tough biodegradable elastomer , 2002, Nature Biotechnology.

[64]  Naoto Tsutsumi,et al.  Network polyester films from glycerol and dicarboxylic acids , 1994 .

[65]  Y. Kimura,et al.  Synthesis and characterization of hydroxy-terminated [RS]-poly(3-hydroxybutyrate) and its utilization to block copolymerization with l-lactide to obtain a biodegradable thermoplastic elastomer , 2000 .

[66]  J. Feijen,et al.  Triblock Copolymers Based on 1,3‐Trimethylene Carbonate and Lactide as Biodegradable Thermoplastic Elastomers , 2003 .

[67]  E. Schacht,et al.  Biodegradable polyesters for controlled release of trypanocidal drugs: in vitro and in vivo studies. , 1998, Biomaterials.

[68]  M. Simons,et al.  Growth factor-induced therapeutic angiogenesis in the heart: protein therapy. , 2005, Cardiovascular research.

[69]  Werner Goldsmith,et al.  Axial mechanical properties of fresh human cerebral blood vessels. , 2003, Journal of biomechanical engineering.

[70]  H. Greisler,et al.  Biomaterials in the development and future of vascular grafts. , 2003, Journal of vascular surgery.

[71]  A. Takahara,et al.  Controlled Release of Model Drug from Biodegradable Segmented Polyurethane Ureas: Morphological and Structural Features , 2006 .

[72]  R. Storey,et al.  Synthesis of bioabsorbable networks from methacrylate-endcapped polyesters , 1993 .

[73]  J. Guan,et al.  Biodegradable elastomeric scaffolds with basic fibroblast growth factor release. , 2007, Journal of controlled release : official journal of the Controlled Release Society.