Web-based Interspecies Correlation Estimation (Web-ICE) for Acute Toxicity: User Manual

.......................................................................................................................... 3 Introduction ..................................................................................................................... 4 Methods .......................................................................................................................... 5 I. Database Development ..................................................................................... 5 Aquatic (Fish and Invertebrates)................................................................ 5 Wildlife (Birds and Mammals) .................................................................... 6 II. Model Development.......................................................................................... 6 III. Model Validation .............................................................................................. 7 Using the Web-ICE Program........................................................................................... 8 I. Working with Web-ICE Aquatic or Web-ICE Wildlife Modules ........................... 9 Selecting Model Taxa ................................................................................ 9 Estimating Toxicity................................................................................... 10 II. The Species Sensitivity Distribution (SSD) Module ........................................ 11 Generating an SSD:................................................................................. 14 III. The Endangered Species Module.................................................................. 14 Producing an Endangered Species Toxicity Report................................. 14 IV. Accessing Model Data................................................................................... 16 Guidance for Model Selection and Use ......................................................................... 17 I. Statistical Definitions ....................................................................................... 17 II. Selecting a Model with Low Uncertainty ......................................................... 18 Rules of Thumb........................................................................................ 18 Surrogate Species Selection: An Example .............................................. 19 III. Evaluating Model Predictions ........................................................................ 19 IV. Selecting Predicted Toxicity Values for SSDs ............................................... 20 V. Applying Web-ICE in Ecological Risk Assessment (ERA).............................. 20 Acknowledgements ....................................................................................................... 22 References.................................................................................................................... 22 Appendices ................................................................................................................... 25

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