Thymidine Auxotrophic Staphylococcus aureus Small-Colony Variant Endocarditis and Left Ventricular Assist Device Infection

ABSTRACT We describe a thymidine-dependent small-colony variant of Staphylococcus aureus associated with left ventricular assist device infection and prosthetic valve and pacemaker endocarditis.

[1]  G. Doern,et al.  Antimicrobial Susceptibility Testing , 2011, Journal of Clinical Microbiology.

[2]  Robin Patel,et al.  Comparison of Direct Colony Method versus Extraction Method for Identification of Gram-Positive Cocci by Use of Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry , 2011, Journal of Clinical Microbiology.

[3]  D. Viemann,et al.  Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence. , 2010, The Journal of infectious diseases.

[4]  J. Healey,et al.  Device‐Related Infection Among Patients With Pacemakers and Implantable Defibrillators: Incidence, Risk Factors, and Consequences , 2010, Journal of cardiovascular electrophysiology.

[5]  Meera Sharma,et al.  Enhanced production of exopolysaccharide matrix and biofilm by a menadione-auxotrophic Staphylococcus aureus small-colony variant. , 2010, Journal of medical microbiology.

[6]  Meera Sharma,et al.  Role of persisters and small-colony variants in antibiotic resistance of planktonic and biofilm-associated Staphylococcus aureus: an in vitro study. , 2009, Journal of medical microbiology.

[7]  T. Wichelhaus,et al.  Thymidine-Dependent Staphylococcus aureus Small-Colony Variants: Human Pathogens That Are Relevant Not Only in Cases of Cystic Fibrosis Lung Disease , 2008, Journal of Clinical Microbiology.

[8]  T. Wichelhaus,et al.  The Thymidine-Dependent Small-Colony-Variant Phenotype Is Associated with Hypermutability and Antibiotic Resistance in Clinical Staphylococcus aureus Isolates , 2008, Antimicrobial Agents and Chemotherapy.

[9]  A. Fischer,et al.  In Vivo Mutations of Thymidylate Synthase (Encoded by thyA) Are Responsible for Thymidine Dependency in Clinical Small-Colony Variants of Staphylococcus aureus , 2007, Journal of bacteriology.

[10]  P. Wayne PERFORMANCE STANDARDS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING, NINTH INFORMATIONAL SUPPLEMENT , 2008 .

[11]  T. Wichelhaus,et al.  Influence of dTMP on the Phenotypic Appearance and Intracellular Persistence of Staphylococcus aureus , 2007, Infection and Immunity.

[12]  T. Wichelhaus,et al.  Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus. , 2007, International journal of medical microbiology : IJMM.

[13]  Robin Patel,et al.  In Vitro Effects of Antimicrobial Agents on Planktonic and Biofilm Forms of Staphylococcus lugdunensis Clinical Isolates , 2006, Antimicrobial Agents and Chemotherapy.

[14]  M. Ziman,et al.  Phenotype Microarray Profiling of Staphylococcus aureus menD and hemB Mutants with the Small-Colony-Variant Phenotype , 2006, Journal of bacteriology.

[15]  Clinical,et al.  Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : Approved standard , 2006 .

[16]  T. Bauer,et al.  Simultaneous Detection of Staphylococcus aureus and Coagulase-Negative Staphylococci in Positive Blood Cultures by Real-Time PCR with Two Fluorescence Resonance Energy Transfer Probe Sets , 2004, Journal of Clinical Microbiology.

[17]  P. Heidenreich,et al.  Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999. , 2004, American heart journal.

[18]  Yung-Hua Li,et al.  Esp-Independent Biofilm Formation by Enterococcus faecalis , 2004, Journal of bacteriology.

[19]  Georg Peters,et al.  Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney. , 2003, The Journal of infectious diseases.

[20]  H. Sahl,et al.  Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants. , 2002, Microbial drug resistance.

[21]  A. Buckling,et al.  Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus , 2001, Current Biology.

[22]  R. Proctor,et al.  Staphylococcus aureus small colony variants, electron transport and persistent infections. , 2000, International journal of antimicrobial agents.

[23]  Mary Jane Ferraro,et al.  Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard , 2000 .

[24]  D. Persing,et al.  Comparison of Susceptibility Testing Methods withmecA Gene Analysis for Determining Oxacillin (Methicillin) Resistance in Clinical Isolates of Staphylococcus aureus and Coagulase-Negative Staphylococcus spp , 1999, Journal of Clinical Microbiology.

[25]  R. Proctor,et al.  Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis. , 1998, The Journal of infectious diseases.

[26]  H. Scheld,et al.  Left ventricular assist device infection is associated with increased mortality but is not a contraindication to transplantation. , 1997, Circulation.

[27]  R. Proctor,et al.  Gentamicin-resistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. , 1994, The Journal of infectious diseases.

[28]  M. Deighton,et al.  Regulation of slime production in Staphylococcus epidermidis by iron limitation , 1993, Infection and immunity.

[29]  P. Gilligan,et al.  Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis , 1987, Journal of clinical microbiology.

[30]  A. Weissfeld,et al.  Comparison of the suitability of three common bacterial media for susceptibility testing of trimethoprim-sulfamethoxazole , 1984, Journal of clinical microbiology.

[31]  J. Gustafson,et al.  Cystic Fibrosis , 2009, Journal of the Iowa Medical Society.

[32]  R. Williams L FORMS OF STAPHYLOCOCCUS AUREUS. , 1963, Journal of general microbiology.