Optimal feeding strategies by adaptive mesh selection for fed-batch bioprocesses

Abstract The objective of this contribution is the design of optimal feeding strategies for fed-batch bioprocesses, where complex dynamic models with input and state constraints are present. For the solution of this dynamic optimization problem a transformation to a finite dimensional optimization problem is made using piecewise linear control profiles. The optimization of these profiles is performed by a sequential approach, that includes an ODE solver for the solution of the model ODE's. Further an adaptive mesh selection algorithm was investigated for an appropriate discretization of the control profiles. The implementation of the resulting optimal feeding profiles is shown for a process example, namely the production of nikkomycin by Streptomyces tendae. This implementation uses a hierarchical process control framework, that consists of components for process monitoring, state estimation, and trajectory control.