Functionalization of 2D transition metal dichalcogenides for biomedical applications.

Recent research has revealed a gamut of interesting properties present in layered two-dimensional (2D) transition metal dichalcogenides (TMDCs) such as photoluminescence, comparatively high electron mobility, flexibility, mechanical strength and relatively low toxicity. The large surface to area ratio inherent in these materials also allows easy functionalization and maximal interaction with the external environment. Due to its unique physical and chemical properties, much work has been done in tailoring TMDCs through chemical functionalization for use in a diverse range of biomedical applications as biosensors, drug delivery carriers or even as therapeutic agents. In this review, current progress on the different types of TMDC functionalization for various biological applications will be presented and its future outlook will be discussed.

[1]  Jun Li,et al.  Supramolecular anchoring of DNA polyplexes in cyclodextrin-based polypseudorotaxane hydrogels for sustained gene delivery. , 2012, Biomacromolecules.

[2]  X. Loh,et al.  Water soluble polyhydroxyalkanoates: future materials for therapeutic applications. , 2015, Chemical Society reviews.

[3]  Liangzhu Feng,et al.  Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. , 2011, ACS nano.

[4]  鳩山 道夫,et al.  Materials Research Bulletinについて , 1967 .

[5]  Wei Huang,et al.  General synthesis of noble metal (Au, Ag, Pd, Pt) nanocrystal modified MoS2 nanosheets and the enhanced catalytic activity of Pd-MoS2 for methanol oxidation. , 2014, Nanoscale.

[6]  J. Gilman,et al.  Nanotechnology , 2001 .

[7]  Wei Chen,et al.  Epitaxial growth and characterization of graphene on free-standing polycrystalline 3C-SiC , 2011 .

[8]  Zhiyuan Zeng,et al.  Metal dichalcogenide nanosheets: preparation, properties and applications. , 2013, Chemical Society reviews.

[9]  Jun Li,et al.  Control of hyperbranched structure of polycaprolactone/poly(ethylene glycol) polyurethane block copolymers by glycerol and their hydrogels for potential cell delivery. , 2013, The journal of physical chemistry. B.

[10]  Hagan Bayley,et al.  Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5'-monophosphates by using an engineered protein nanopore equipped with a molecular adapter. , 2006 .

[11]  Ke Liu,et al.  Atomically thin molybdenum disulfide nanopores with high sensitivity for DNA translocation. , 2014, ACS nano.

[12]  Chunming Wang,et al.  A novel way for detection of eugenol via poly (diallyldimethylammonium chloride) functionalized graphene-MoS2 nano-flower fabricated electrochemical sensor , 2014 .

[13]  N. Aluru,et al.  DNA base detection using a single-layer MoS2. , 2014, ACS nano.

[14]  Junjie Zhu,et al.  Graphene-like two-dimensional layered nanomaterials: applications in biosensors and nanomedicine. , 2015, Nanoscale.

[15]  Zhang Jun,et al.  ADVANCED FUNCTIONAL MATERIALS BASED ON CELLULOSE , 2010 .

[16]  Guorui Jin,et al.  Design of polyhedral oligomeric silsesquioxane (POSS) based thermo-responsive amphiphilic hybrid copolymers for thermally denatured protein protection applications , 2014 .

[17]  Lan Wang,et al.  Electrochemical sensing based on layered MoS2–graphene composites , 2013 .

[18]  H. Bayley,et al.  Continuous base identification for single-molecule nanopore DNA sequencing. , 2009, Nature nanotechnology.

[19]  Weibo Cai,et al.  Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy. , 2015, ACS nano.

[20]  Y. Shao,et al.  Direct detection of DNA below ppb level based on thionin-functionalized layered MoS2 electrochemical sensors. , 2014, Analytical chemistry.

[21]  Jun Jin,et al.  MoS2 nanosheet functionalized with Cu nanoparticles and its application for glucose detection , 2013 .

[22]  Mrinmoy De,et al.  Ligand conjugation of chemically exfoliated MoS2. , 2013, Journal of the American Chemical Society.

[23]  Hua Zhang,et al.  The chemistry of two-dimensional layered transition metal dichalcogenide nanosheets. , 2013, Nature chemistry.

[24]  Bing Li,et al.  High-Yield Exfoliation of Ultrathin Two-Dimensional Ternary Chalcogenide Nanosheets for Highly Sensitive and Selective Fluorescence DNA Sensors. , 2015, Journal of the American Chemical Society.

[25]  Haiyan Song,et al.  Investigations of an electrochemical platform based on the layered MoS2-graphene and horseradish peroxidase nanocomposite for direct electrochemistry and electrocatalysis. , 2014, Biosensors & bioelectronics.

[26]  Zhuang Liu,et al.  Two-dimensional TiS₂ nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy. , 2015, Nanoscale.

[27]  Liang Cheng,et al.  Drug Delivery with PEGylated MoS2 Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer , 2014, Advanced materials.

[28]  Martin Pumera,et al.  Two‐Dimensional Transition Metal Dichalcogenides in Biosystems , 2015 .

[29]  E. Hall,et al.  The nature of biotechnology. , 1988, Journal of biomedical engineering.

[30]  Ru-Qin Yu,et al.  Highly sensitive and selective strategy for microRNA detection based on WS2 nanosheet mediated fluorescence quenching and duplex-specific nuclease signal amplification. , 2014, Analytical chemistry.

[31]  K. Marra,et al.  Journal of Materials Chemistry B themed issue: stem cells. , 2016, Journal of materials chemistry. B.

[32]  Hongxiang Li,et al.  Synthesis of strongly fluorescent molybdenum disulfide nanosheets for cell-targeted labeling. , 2014, ACS applied materials & interfaces.

[33]  Zhihong Liu,et al.  Establishing water-soluble layered WS₂ nanosheet as a platform for biosensing. , 2014, Analytical chemistry.

[34]  Chunhai Fan,et al.  Single-layer MoS2-based nanoprobes for homogeneous detection of biomolecules. , 2013, Journal of the American Chemical Society.

[35]  Yu Chen,et al.  Two-dimensional graphene analogues for biomedical applications. , 2015, Chemical Society reviews.

[36]  Ling-Ling Wang,et al.  Novel electrochemical sensing platform based on molybdenum disulfide nanosheets-polyaniline composites and Au nanoparticles , 2014 .

[37]  Xiaojuan Zhao,et al.  Synthesis of Ag-MoS2/chitosan nanocomposite and its application for catalytic oxidation of tryptophan , 2014 .

[38]  Bo Chen,et al.  Single‐Layer Transition Metal Dichalcogenide Nanosheet‐Based Nanosensors for Rapid, Sensitive, and Multiplexed Detection of DNA , 2015, Advanced materials.

[39]  D. Branton,et al.  The potential and challenges of nanopore sequencing , 2008, Nature Biotechnology.

[40]  Adv , 2019, International Journal of Pediatrics and Adolescent Medicine.

[41]  K. Schanze,et al.  ACS Applied Materials & Interfaces and Chemistry of Materials To Exclusively Publish Full Articles in 2019 , 2019, Chemistry of Materials.

[42]  Guo-Jun Zhang,et al.  A WS2 nanosheet-based platform for fluorescent DNA detection via PNA-DNA hybridization. , 2015, The Analyst.

[43]  Ye Ai,et al.  A novel single-layered MoS2 nanosheet based microfluidic biosensor for ultrasensitive detection of DNA. , 2015, Nanoscale.

[44]  Ke-Jing Huang,et al.  Synthesis and electrochemical performances of layered tungsten sulfide-graphene nanocomposite as a sensing platform for catechol, resorcinol and hydroquinone , 2013 .

[45]  O. Urakawa,et al.  Small - , 2007 .

[46]  H. Gerischer,et al.  Influence of crystal surface orientation on redox reactions at semiconducting MoS2 , 1979 .

[47]  Andre K. Geim,et al.  Electric Field Effect in Atomically Thin Carbon Films , 2004, Science.

[48]  Hsieh-Chih Tsai,et al.  Highly concentrated MoS2 nanosheets in water achieved by thioglycolic acid as stabilizer and used as biomarkers , 2014 .

[49]  D. Chi,et al.  CVD Growth of MoS2‐based Two‐dimensional Materials , 2015 .

[50]  P. Annibale,et al.  ssDNA binding reveals the atomic structure of graphene. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[51]  Wei Chen,et al.  Quasi-free-standing epitaxial graphene on SiC (0001) by fluorine intercalation from a molecular source. , 2011, ACS nano.

[52]  Martin Pumera,et al.  Layered transition-metal dichalcogenides (MoS2 and WS2) for sensing and biosensing , 2014 .

[53]  Zhiyuan Zeng,et al.  Solution-phase epitaxial growth of noble metal nanostructures on dispersible single-layer molybdenum disulfide nanosheets , 2013, Nature Communications.

[54]  Philip D. Rack,et al.  Chemical Vapor Deposition , 2002 .

[55]  A. Agostino,et al.  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2014 .

[56]  Lain‐Jong Li,et al.  Graphene/MoS2 Heterostructures for Ultrasensitive Detection of DNA Hybridisation , 2014, Advanced materials.

[57]  Zhuang Liu,et al.  MoS2-based nanoprobes for detection of silver ions in aqueous solutions and bacteria. , 2015, ACS applied materials & interfaces.

[58]  SUPARNA DUTTASINHA,et al.  Van der Waals heterostructures , 2013, Nature.

[59]  Zibiao Li,et al.  Poly(ethylene glycol) conjugated poly(lactide)-based polyelectrolytes: synthesis and formation of stable self-assemblies induced by stereocomplexation. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[60]  Jun Li,et al.  Biodegradable hyperbranched amphiphilic polyurethane multiblock copolymers consisting of poly(propylene glycol), poly(ethylene glycol), and polycaprolactone as in situ thermogels. , 2012, Biomacromolecules.

[61]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[62]  K. Banerjee,et al.  MoS₂ field-effect transistor for next-generation label-free biosensors. , 2014, ACS nano.

[63]  Jun Jin,et al.  A novel glucose sensor based on MoS2 nanosheet functionalized with Ni nanoparticles , 2014 .

[64]  Wei Chen,et al.  STM studies of epitaxial graphene , 2012 .

[65]  Xinyi Su,et al.  Recent Progress in Using Biomaterials as Vitreous Substitutes. , 2015, Biomacromolecules.

[66]  Hua Zhang,et al.  Two-dimensional transition metal dichalcogenide nanosheet-based composites. , 2015, Chemical Society reviews.

[67]  Lu Wang,et al.  Functionalized MoS(2) nanosheet-based field-effect biosensor for label-free sensitive detection of cancer marker proteins in solution. , 2014, Small.

[68]  I. S. Turan,et al.  RSC Advances , 2015 .

[69]  L. Lauhon,et al.  Emerging device applications for semiconducting two-dimensional transition metal dichalcogenides. , 2014, ACS nano.

[70]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[71]  L. Christophorou Science , 2018, Emerging Dynamics: Science, Energy, Society and Values.

[72]  Yuanyi Zheng,et al.  Injectable 2D MoS2‐Integrated Drug Delivering Implant for Highly Efficient NIR‐Triggered Synergistic Tumor Hyperthermia , 2015, Advanced materials.

[73]  Dumitru Dumcenco,et al.  Identification of single nucleotides in MoS2 nanopores. , 2015, Nature nanotechnology.

[74]  Jie Yu,et al.  High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. , 2014, ACS nano.

[75]  Xiaoxue Zeng,et al.  A turn-off fluorescent biosensor for the rapid and sensitive detection of uranyl ion based on molybdenum disulfide nanosheets and specific DNAzyme. , 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[76]  Alessandra Bonanni,et al.  Molybdenum disulfide (MoS2) nanoflakes as inherently electroactive labels for DNA hybridization detection. , 2014, Nanoscale.

[77]  Zibiao Li,et al.  Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications. , 2014, Materials science & engineering. C, Materials for biological applications.

[78]  Jie Chao,et al.  A MoS2–based system for efficient immobilization of hemoglobin and biosensing applications , 2015, Nanotechnology.

[79]  Tianran Lin,et al.  Visual detection of blood glucose based on peroxidase-like activity of WS2 nanosheets. , 2014, Biosensors & bioelectronics.

[80]  Xiaopeng Zheng,et al.  WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells. , 2014, Nanoscale.

[81]  Gang Liu,et al.  PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy , 2014, Advanced materials.

[82]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[83]  A. Radenović,et al.  Single-layer MoS2 transistors. , 2011, Nature nanotechnology.

[84]  W Bryce TrAC—trends in analytical chemistry, reference edition vol. 7 Elsevier, Amsterdam, 1988, Pages xii + 404. US$200.0, Dfl. 380.00. , 1991 .

[85]  Hee‐Tae Jung,et al.  Tunable volatile organic compounds sensor by using thiolated ligand conjugation on MoS2. , 2014, Nano letters.