Can a biologist fix a radio? — or, what I learned while studying apoptosis

This article by Yu. Lazebnik, “Can a Biologist Fix a Radio? — or, What I Learned while Studying Apoptosis” has already been published in English (Cancer Cell, 2002, 2, 179–182) and in Russian (Uspekhi Gerontologii, 2003, No. 12, 166–171). Nevertheless, we have undertaken its secondary publication in our journal for two reasons: first, our journal has different readers, and, second, the great significance of this manifest of Yuri Lazebnik. The author in bright and clever form shows the emerging necessity to create formalized language designed to describe complicated systems of regulation of biochemical processes in living cells. The article is published with permission of Cancer Cell and Uspekhi Gerontologii.Editor-in-Chief of Biokhimiya/Biochemistry (Moscow) V.P.Skulachev

[1]  Lotfi A. Zadeh,et al.  General System Theory , 1962 .

[2]  E Friedman,et al.  Loose ends. , 2020, The Healthcare Forum journal.

[3]  D. Bray.  Protein molecules as computational elements in living cells , 1995, Nature.

[4]  U. Bhalla,et al.  Emergent properties of networks of biological signaling pathways. , 1999, Science.

[5]  K. Kohn.  Molecular interaction map of the mammalian cell cycle control and DNA repair systems. , 1999, Molecular biology of the cell.

[6]  J. Hopfield,et al.  From molecular to modular cell biology , 1999, Nature.

[7]  J. Dumont,et al.  The visual display of regulatory information and networks. , 2000, Trends in cell biology.

[8]  Dennis Bray.  Reasoning for results , 2001, Nature.

[9]  Ron Maimon,et al.  Diagrammatic Notation and Computational Structure of Gene Networks , 2001 .

[10]  Prahlad T. Ram,et al.  MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network , 2002, Science.

[11]  J. Doyle,et al.  Reverse Engineering of Biological Complexity , 2002, Science.

[12]  E. Gilles,et al.  Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors , 2002, Nature Biotechnology.

[13]  M. Elowitz,et al.  Combinatorial Synthesis of Genetic Networks , 2002, Science.

[14]  Eric H Davidson,et al.  A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. , 2002, Developmental biology.