Computer simulation of cellular movements: cell-sorting, cellular migration through a mass of cells and contact inhibition.

Abstract The motility rules for cellular movement proposed earlier by Goel & Rogers for engulfment of two or more intact embryonic tissues have been used to simulate on a computer the phenomena of cell-sorting, migration of individual cells through a mass of cells and contact inhibition of overlapping. These simulations in the most part are found to be consistent with the observations with real cells.

[1]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. II. Monolayering of fibroblasts. , 1954, Experimental cell research.

[2]  M. Abercrombie,et al.  Cell mobility in fused homo- and heteronomic tissue fragments. , 1967, The Journal of experimental zoology.

[3]  N S Goel,et al.  A rheological mechanism sufficient to explain the kinetics of cell sorting. , 1972, Journal of theoretical biology.

[4]  J. Trinkaus Cells into organs , 1969 .

[5]  G. Gorbsky,et al.  Is the movement of single cells within solid tissue masses induced by trypsinization? , 1976, Experimental cell research.

[6]  M. S. Steinberg,et al.  Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells. , 1970, The Journal of experimental zoology.

[7]  M Ycas,et al.  Self-sorting of isotropic cells. , 1970, Journal of theoretical biology.

[8]  Brian W. Kernighan,et al.  Elements of Programming Style , 1974 .

[9]  M. S. Steinberg,et al.  Adhesion-guided multicellular assembly: a commentary upon the postulates, real and imagined, of the differential adhesion hypothesis, with special attention to computer simulations of cell sorting. , 1975, Journal of theoretical biology.

[10]  M. S. Steinberg,et al.  The movement of single cells within solid tissue masses. , 1973, Experimental cell research.

[11]  M. Abercrombie,et al.  The surface properties of cancer cells: a review. , 1962, Cancer research.

[12]  N. Goel Cooperative Processes in Biological Systems , 1972 .

[13]  D. Garrod,et al.  Observations on the sorting-out of embryonic cells in monolayer culture. , 1975, Journal of cell science.

[14]  M. S. Steinberg,et al.  Contact inhibition of what? An analytical review , 1973, Journal of cellular physiology.

[15]  N. Goel,et al.  Simulation of movement of cells during self-sorting. , 1971, Journal of theoretical biology.

[16]  H. Gershman,et al.  Mobility of normal and virus-transformed cells in cellular aggregates , 1975, The Journal of cell biology.

[17]  N S Goel,et al.  Computer simulation of engulfment and other movements of embryonic tissues. , 1978, Journal of theoretical biology.

[18]  M. S. Steinberg,et al.  Experimental modulation of intercellular cohesiveness: reversal of tissue assembly patterns. , 1972, Developmental biology.

[19]  M. S. Steinberg,et al.  Movement in a confluent 3T3 monolayer and the causes of contact inhibition of overlapping. , 1974, Journal of cell science.

[20]  M. S. Steinberg,et al.  Contact inhibitions of overlapping and differential cell adhesion: a sufficient model for the control of certain cell culture morphologies. , 1974, Journal of cell science.