Can innate immunity be enhanced to treat microbial infections?
暂无分享,去创建一个
[1] M. Fares,et al. Evidence of Positively Selected Sites in Mammalian α-Defensins , 2004 .
[2] R. Hancock,et al. The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-Regulated Kinase and p38 Kinase Pathways in Primary Human Monocytes1 , 2004, The Journal of Immunology.
[3] R. Flavell,et al. Shielding the double‐edged sword: negative regulation of the innate immune system , 2004, Journal of leukocyte biology.
[4] B. Finlay,et al. Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[5] D. Philpott,et al. Innate immunity via Toll-like receptors and Nod proteins. , 2004, Current opinion in microbiology.
[6] B. Beutler. Innate immunity: an overview. , 2004, Molecular immunology.
[7] T. Falla,et al. Cationic antimicrobial peptides – an update , 2004, Expert opinion on investigational drugs.
[8] Robert E. W. Hancock,et al. The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization1 , 2004, The Journal of Immunology.
[9] T. Sawyer. Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors , 2004, Expert opinion on investigational drugs.
[10] K. Rabe,et al. The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor 1 , 2003, The Journal of Immunology.
[11] S. Akira,et al. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. , 2003, Immunity.
[12] J. Holmgren,et al. Orally Administered CpG Oligodeoxynucleotide Induces Production of CXC and CC Chemokines in the Gastric Mucosa and Suppresses Bacterial Colonization in a Mouse Model of Helicobacter pylori Infection , 2003, Infection and Immunity.
[13] U. Hengge,et al. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum , 2003, The British journal of dermatology.
[14] Zhenghong Yuan,et al. Toll‐like receptor‐9 induced by physical trauma mediates release of cytokines following exposure to CpG motif in mouse skin , 2003, Immunology.
[15] S. Akira,et al. Mycobacterial Infection in MyD88‐Deficient Mice , 2003, Microbiology and immunology.
[16] J. Dorin,et al. Rapid sequence divergence in mammalian β-defensins by adaptive evolution , 2003 .
[17] L. Kwak,et al. Roles of antimicrobial peptides such as defensins in innate and adaptive immunity , 2003, Annals of the rheumatic diseases.
[18] S. Akira,et al. MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis , 2003, The Journal of experimental medicine.
[19] C. Hackett. Innate immune activation as a broad-spectrum biodefense strategy , 2003, Journal of Allergy and Clinical Immunology.
[20] D. Klinman,et al. Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. , 2003, Clinical immunology.
[21] U. Dittmer,et al. Treatment of infectious diseases with immunostimulatory oligodeoxynucleotides containing CpG motifs. , 2003, Current opinion in microbiology.
[22] D. Hoover,et al. Many chemokines including CCL20/MIP‐3α display antimicrobial activity , 2003 .
[23] T. Ganz. Defensins: antimicrobial peptides of innate immunity , 2003, Nature reviews. Immunology.
[24] D. Kuhns,et al. Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections , 2003, The Journal of experimental medicine.
[25] H. Lee,et al. CpG motif in synthetic ODN primes respiratory burst of olive flounder Paralichthys olivaceus phagocytes and enhances protection against Edwardsiella tarda. , 2003, Diseases of aquatic organisms.
[26] Jiahuai Han,et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling , 2003, Nature.
[27] K. Herzig,et al. Antimicrobial peptides in innate immunity of the human intestine , 2003, Journal of Gastroenterology.
[28] Piero Carninci,et al. Genetic control of the innate immune response , 2003, BMC Immunology.
[29] Carrie M. Rosenberger,et al. Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens , 2003, Nature Reviews Molecular Cell Biology.
[30] N. Salzman,et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin , 2003, Nature.
[31] Richard D Emes,et al. Comparison of the genomes of human and mouse lays the foundation of genome zoology. , 2003, Human molecular genetics.
[32] L. Babiuk,et al. Protection of Chickens against Escherichia coli Infections by DNA Containing CpG Motifs , 2003, Infection and Immunity.
[33] Takaaki Ohtake,et al. Biology and clinical relevance of naturally occurring antimicrobial peptides. , 2002, The Journal of allergy and clinical immunology.
[34] L. Kwak,et al. Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2 , 2002, Science.
[35] M. Hornef,et al. Bacterial strategies for overcoming host innate and adaptive immune responses , 2002, Nature Immunology.
[36] R. Hancock,et al. The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1 , 2002, The Journal of Immunology.
[37] R. Coler,et al. Taking toll: lipid A mimetics as adjuvants and immunomodulators. , 2002, Trends in microbiology.
[38] James M. Wilson,et al. β-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice , 2002, Infection and Immunity.
[39] K. Iwabuchi,et al. A cathelicidin family of human antibacterial peptide LL‐37 induces mast cell chemotaxis , 2002, Immunology.
[40] M. Zasloff. Antimicrobial peptides of multicellular organisms , 2002, Nature.
[41] Takaaki Ohtake,et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.
[42] R. Hancock,et al. Cationic peptides: effectors in innate immunity and novel antimicrobials. , 2001, The Lancet. Infectious diseases.
[43] S. Akira,et al. A Toll-like receptor recognizes bacterial DNA , 2000, Nature.
[44] Chi-Chao Chan,et al. Therapeutic Applications of Antiflammin Peptides in Experimental Ocular Inflammation , 2000, Annals of the New York Academy of Sciences.
[45] Ji Ming Wang,et al. Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells , 2000, The Journal of experimental medicine.
[46] B. Finlay,et al. An α-Helical Cationic Antimicrobial Peptide Selectively Modulates Macrophage Responses to Lipopolysaccharide and Directly Alters Macrophage Gene Expression1 , 2000, The Journal of Immunology.
[47] R. Hancock,et al. The role of cationic antimicrobial peptides in innate host defences. , 2000, Trends in microbiology.
[48] G. H. Gudmundsson,et al. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system. , 1999, Journal of immunological methods.
[49] S. Stibitz,et al. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. , 1999, Journal of immunology.
[50] K. Heeg,et al. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. , 1998, Journal of immunology.
[51] R. Hancock,et al. Antiendotoxin activity of cationic peptide antimicrobial agents , 1996, Infection and immunity.
[52] D. Dunn,et al. Peptide derivatives of three distinct lipopolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha secretion in vitro. , 1995, Surgery.
[53] B. Gray,et al. Bactericidal activity of synthetic peptides based on the structure of the 55-kilodalton bactericidal protein from human neutrophils , 1994, Infection and immunity.
[54] S. Holland,et al. Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report. , 1994, The New England journal of medicine.
[55] P. Ghezzi,et al. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides. , 1993, Science.
[56] M. Bevan,et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens , 2004, Nature Immunology.
[57] S. Tauszig-Delamasure,et al. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections , 2002, Nature Immunology.
[58] P. Hiemstra,et al. Neutrophil defensins stimulate the release of cytokines by airway epithelial cells: modulation by dexamethasone , 2002, Inflammation Research.
[59] Chen Dong,et al. MAP kinases in the immune response. , 2002, Annual review of immunology.
[60] C. Janeway,et al. Innate immune recognition. , 2002, Annual review of immunology.
[61] J. Larrick,et al. Endotoxin-binding synthetic peptides with endotoxin-neutralizing, antibacterial and anticoagulant activities. , 1994, Progress in clinical and biological research.