Alterations in the Blood Histamine in Shock

Conclusions In a series of patients in varying types of shock manifested by clinical signs, hemoconcentration, and lowering of the B.P. the total blood histamine has been determined. The results indicate that in the cases studied a marked diminution of the histamine content of the blood occurs when shock is established as compared with control values and those after recovery. There appears to be some correlation between the severity of the shock and the degree of blood histamine decrease. Blood histamine has also been found to be low in agonal states. The significance of these findings is discussed.