Thrombin Generation in Trauma Patients: How Do we Navigate Through Scylla and Charybdis?

[1]  K. Vandyck,et al.  Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding. , 2021, Transfusion medicine reviews.

[2]  A. Sauaia,et al.  Trauma-induced coagulopathy , 2021, Nature Reviews Disease Primers.

[3]  A. Sabaté,et al.  Altered Fibrinolysis during and after Surgery , 2021, Seminars in Thrombosis and Hemostasis.

[4]  S. McCluskey,et al.  Comparison of 4-Factor Prothrombin Complex Concentrate With Frozen Plasma for Management of Hemorrhage During and After Cardiac Surgery , 2021, JAMA network open.

[5]  B. Merkely,et al.  Perioperative Factor Concentrate Use is Associated With More Beneficial Outcomes and Reduced Complication Rates Compared With a Pure Blood Product-Based Strategy in Patients Undergoing Elective Cardiac Surgery: A Propensity Score-Matched Cohort Study. , 2021, Journal of cardiothoracic and vascular anesthesia.

[6]  G. Ricevuti,et al.  Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes , 2021, Medicines.

[7]  J. Cardenas Thrombin Generation Following Severe Trauma: Mechanisms, Modulators, and Implications for Hemostasis and Thrombosis , 2021, Shock.

[8]  K. Bailey,et al.  Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study , 2021, Research and practice in thrombosis and haemostasis.

[9]  H. Hemker,et al.  Thrombin–Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis , 2021, International journal of molecular sciences.

[10]  James G. Chandler,et al.  Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion. , 2021, Journal of the American College of Surgeons.

[11]  J. Cooper,et al.  Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial) , 2020, Anaesthesia.

[12]  H. Schöchl,et al.  Sufficient Thrombin Generation Despite 95% Hemodilution: An In Vitro Experimental Study , 2020, Journal of clinical medicine.

[13]  A. Kirkpatrick,et al.  Back to the Future: Whole Blood Resuscitation of the Severely Injured Trauma Patient , 2020, Shock.

[14]  Andreas Brännström,et al.  The swine as a vehicle for research in trauma induced coagulopathy: introducing Principal Component Analysis for viscoelastic coagulation tests. , 2020, The journal of trauma and acute care surgery.

[15]  H. Schöchl,et al.  Trauma-Induced Coagulopathy and Massive Bleeding: Current Hemostatic Concepts and Treatment Strategies , 2020, Hämostaseologie.

[16]  M. Mckenney,et al.  Antithrombin Deficiency in Trauma and Surgical Critical Care. , 2020, The Journal of surgical research.

[17]  A. Koster,et al.  A European consensus statement on the use of four‐factor prothrombin complex concentrate for cardiac and non‐cardiac surgical patients , 2020, Anaesthesia.

[18]  Arun V. Kolanjiyil,et al.  Injury Length and Arteriole Constriction Shape Clot Growth and Blood-Flow Acceleration in a Mouse Model of Thrombosis , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[19]  J. Binnekade,et al.  Effectiveness of prothrombin complex concentrate for the treatment of bleeding: A systematic review and meta‐analysis , 2020, Journal of thrombosis and haemostasis : JTH.

[20]  S. Kristensen,et al.  Reply to a letter from Jackson J et al: Effect of pH on thrombin activity measured by calibrated automated thrombinography , 2020, Research and practice in thrombosis and haemostasis.

[21]  A. Atala,et al.  Microfluidic devices for studying coagulation biology. , 2020, Seminars in cell & developmental biology.

[22]  S. Surov,et al.  Effect of pH on thrombin activity measured by calibrated automated thrombinography , 2020, Research and practice in thrombosis and haemostasis.

[23]  Kimberly A. Thomas,et al.  The use of low‐titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage , 2020, Transfusion.

[24]  M. Midwinter,et al.  A prospective observational study of acute traumatic coagulopathy in traumatic bleeding from the battlefield , 2020, Transfusion.

[25]  Tie Bo Wu,et al.  Computational model of tranexamic acid on urokinase mediated fibrinolysis , 2020, PloS one.

[26]  C. Gabriel,et al.  Comparison of fresh frozen plasma vs. coagulation factor concentrates for reconstitution of blood , 2020, European journal of anaesthesiology.

[27]  K. Karkouti,et al.  Thrombin generation and bleeding in cardiac surgery: a clinical narrative review , 2020, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

[28]  N. White,et al.  Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy , 2020, Seminars in Thrombosis and Hemostasis.

[29]  M. Roest,et al.  A novel assay for studying the involvement of blood cells in whole blood thrombin generation , 2020, Journal of thrombosis and haemostasis : JTH.

[30]  S. Kristensen,et al.  The effect of pH on thrombin generation–An unrecognized potential source of variation , 2020, Research and practice in thrombosis and haemostasis.

[31]  C. Wade,et al.  Supplementation with antithrombin III ex vivo optimizes enoxaparin responses in critically injured patients. , 2020, Thrombosis research.

[32]  J. Barr,et al.  Lactic Acidosis and The Role of Sodium Bicarbonate: A Narrative Opinion. , 2020, Shock.

[33]  J. Reifman,et al.  Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro , 2020, Anesthesia and analgesia.

[34]  K. Brohi,et al.  Surgery in Traumatic Injury and Perioperative Considerations , 2019, Seminars in Thrombosis and Hemostasis.

[35]  J. Fenton Thrombin , 2019, Reactions Weekly.

[36]  C. Négrier,et al.  The central role of thrombin in bleeding disorders. , 2019, Blood reviews.

[37]  E. Moore,et al.  Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury. , 2019, Surgery.

[38]  Ashley C. Brown,et al.  Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation. , 2019, Anesthesiology.

[39]  R. Rossaint,et al.  Prothrombin Complex Concentrate-induced Disseminated Intravascular Coagulation Can Be Prevented by Coadministering Antithrombin in a Porcine Trauma Model. , 2019, Anesthesiology.

[40]  A. Sauaia,et al.  Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy. , 2019, American journal of surgery.

[41]  J. Reifman,et al.  Microfluidic and computational study of structural properties and resistance to flow of blood clots under arterial shear , 2019, Biomechanics and Modeling in Mechanobiology.

[42]  J. Vincent,et al.  The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition , 2019, Critical Care.

[43]  T. Orfeo,et al.  Utilizing Plasma Composition Data to Help Determine Procoagulant Dynamics in Patients with Thermal Injury: A Computational Assessment. , 2019, Military medicine.

[44]  J. Weisel,et al.  Interrelationships between structure and function during the hemostatic response to injury , 2019, Proceedings of the National Academy of Sciences.

[45]  F. Biancari,et al.  Comparative Analysis of Prothrombin Complex Concentrate and Fresh Frozen Plasma in Coronary Surgery. , 2019, Heart, lung & circulation.

[46]  E. Moore,et al.  Whole blood mitigates the acute coagulopathy of trauma and avoids the coagulopathy of crystalloid resuscitation , 2018, The journal of trauma and acute care surgery.

[47]  J. Heemskerk,et al.  Platelet biology and functions: new concepts and clinical perspectives , 2018, Nature Reviews Cardiology.

[48]  M. Mazzeffi,et al.  Factor IX from prothrombin complex concentrate augments low dose tissue factor‐triggered thrombin generation in vitro , 2018, British journal of anaesthesia.

[49]  J. Sperry,et al.  Clinical outcomes among low‐titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation , 2018, Transfusion.

[50]  M. Aibiki,et al.  Decreased antithrombin activity in the early phase of trauma is strongly associated with extravascular leakage, but not with antithrombin consumption: a prospective observational study , 2018, Thrombosis Journal.

[51]  Michael T. Stobb,et al.  A local and global sensitivity analysis of a mathematical model of coagulation and platelet deposition under flow , 2018, PloS one.

[52]  M. Kuno,et al.  In Response. , 2018, Anesthesia and analgesia.

[53]  Tie Bo Wu,et al.  Computational Model for Hyperfibrinolytic Onset of Acute Traumatic Coagulopathy , 2018, Annals of Biomedical Engineering.

[54]  S. Diamond,et al.  Multiscale systems biology of trauma‐induced coagulopathy , 2018, Wiley interdisciplinary reviews. Systems biology and medicine.

[55]  A. Zia,et al.  Rivaroxaban dose adjustment using thrombin generation in severe congenital protein C deficiency and warfarin-induced skin necrosis. , 2018, Blood advances.

[56]  P. Monagle,et al.  A review of commercially available thrombin generation assays , 2017, Research and practice in thrombosis and haemostasis.

[57]  M. Mazzeffi,et al.  Acute Intracardiac Thrombosis and Pulmonary Thromboembolism After Cardiopulmonary Bypass: A Systematic Review of Reported Cases , 2017, Anesthesia and analgesia.

[58]  K. Mann,et al.  Continuous thrombin generation in whole blood: New applications for assessing activators and inhibitors of coagulation. , 2018, Analytical biochemistry.

[59]  W. Chandler,et al.  Thrombin Generation Assay: Are We Ready for Prime Time? , 2017, The journal of applied laboratory medicine.

[60]  H. Schöchl,et al.  Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate , 2017, Anesthesia and analgesia.

[61]  M. Mazzeffi,et al.  Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma From Liver Transplant Recipients , 2017, Anesthesia and analgesia.

[62]  C. Gabriel,et al.  Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh‐frozen plasma , 2017, Transfusion.

[63]  C. Wade,et al.  Reply to: is "Thrombin Burst" Now the Worst Option in Trauma? , 2017, Shock.

[64]  A. Mayr,et al.  Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. , 2017, The Lancet. Haematology.

[65]  M. Cohen,et al.  Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment , 2017, The journal of trauma and acute care surgery.

[66]  M. Croce,et al.  1: 1 Transfusion strategies are right for the wrong reasons , 2017, The journal of trauma and acute care surgery.

[67]  A. Wolberg,et al.  Fibrinogen and Fibrin in Hemostasis and Thrombosis. , 2017, Arteriosclerosis, thrombosis, and vascular biology.

[68]  M. Cohen,et al.  Individual clotting factor contributions to mortality following trauma , 2017, The journal of trauma and acute care surgery.

[69]  A. Arkin,et al.  Targeted clinical control of trauma patient coagulation through a thrombin dynamics model , 2017, Science Translational Medicine.

[70]  J. Holcomb,et al.  Implementation of Massive Transfusion Protocols in the United States: The Relationship Between Evidence and Practice. , 2017, Anesthesia and analgesia.

[71]  C. Thiemermann,et al.  Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy , 2017, Anesthesiology.

[72]  R. Dutton,et al.  Massive Transfusion Protocols: A Survey of Academic Medical Centers in the United States , 2017, Anesthesia and analgesia.

[73]  P. Spinella,et al.  Whole blood: back to the future. , 2016, Current opinion in hematology.

[74]  T. Orfeo,et al.  Effects of an acidic environment on coagulation dynamics , 2016, Journal of thrombosis and haemostasis : JTH.

[75]  J. Reifman,et al.  A Step Toward Balance: Thrombin Generation Improvement via Procoagulant Factor and Antithrombin Supplementation , 2016, Anesthesia and analgesia.

[76]  R. Rossaint,et al.  Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury , 2016, Anesthesia and analgesia.

[77]  J. Maessen,et al.  A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding , 2016, Thrombosis and Haemostasis.

[78]  J. Reifman,et al.  Computational Study of Thrombus Formation and Clotting Factor Effects under Venous Flow Conditions , 2016, Biophysical journal.

[79]  Kenichi A. Tanaka,et al.  Optimizing Thrombin Generation with 4-Factor Prothrombin Complex Concentrates in Neonatal Plasma After Cardiopulmonary Bypass , 2016, Anesthesia and analgesia.

[80]  M. Cohen,et al.  Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood , 2016, PloS one.

[81]  S. Diamond,et al.  Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology , 2016, The journal of trauma and acute care surgery.

[82]  C. Wade,et al.  Plasma Resuscitation Promotes Coagulation Homeostasis Following Shock-Induced Hypercoagulability , 2016, Shock.

[83]  James G. Chandler,et al.  Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients , 2016, The journal of trauma and acute care surgery.

[84]  M. Mazzeffi,et al.  Computational simulation and comparison of prothrombin complex concentrate dosing schemes for warfarin reversal in cardiac surgery , 2016, Journal of Anesthesia.

[85]  P. Mintz,et al.  Clotting factor product administration and same‐day occurrence of thrombotic events, as recorded in a large healthcare database during 2008–2013 , 2015, Journal of thrombosis and haemostasis : JTH.

[86]  W. Harmsen,et al.  Thrombin generation and procoagulant microparticle profiles after acute trauma: A prospective cohort study , 2015, The journal of trauma and acute care surgery.

[87]  J. Fraser,et al.  Experimental Animal Models of Traumatic Coagulopathy: A Systematic Review , 2015, Shock.

[88]  E. Jonge,et al.  Fresh frozen plasma transfusion fails to influence the hemostatic balance in critically ill patients with a coagulopathy , 2015, Journal of thrombosis and haemostasis : JTH.

[89]  G. Brophy,et al.  Early hemostatic responses to trauma identified with hierarchical clustering analysis , 2015, Journal of thrombosis and haemostasis : JTH.

[90]  R. Kozar,et al.  Syndecan-1 restitution by plasma after hemorrhagic shock , 2015, The journal of trauma and acute care surgery.

[91]  J. Levy,et al.  Prothrombin complex concentrates in trauma and perioperative bleeding. , 2015, Anesthesiology.

[92]  M. Lancé A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis , 2015, Thrombosis Journal.

[93]  C. Wade,et al.  Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma , 2014, The journal of trauma and acute care surgery.

[94]  A. Sauaia,et al.  A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis. , 2014, Surgery.

[95]  E. Fox,et al.  Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. , 2014, Thrombosis research.

[96]  J. Reifman,et al.  Kinetic model facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies. , 2014, Molecular bioSystems.

[97]  M. Schreiber,et al.  Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate , 2014, British journal of anaesthesia.

[98]  W. Voelckel,et al.  Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational study of trauma patients , 2014, Critical Care.

[99]  M. A. Meledeo,et al.  Comparative Response of Platelet fV and Plasma fV to Activated Protein C and Relevance to a Model of Acute Traumatic Coagulopathy , 2014, PloS one.

[100]  K. Brummel-Ziedins,et al.  Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance. , 2014, Thrombosis research.

[101]  K. Brummel-Ziedins,et al.  Thrombin generation and fibrin clot formation under hypothermic conditions: an in vitro evaluation of tissue factor initiated whole blood coagulation. , 2014, Journal of critical care.

[102]  F. Szlam,et al.  Augmentation of thrombin generation in neonates undergoing cardiopulmonary bypass. , 2014, British journal of anaesthesia.

[103]  K. Neeves,et al.  The hydraulic permeability of blood clots as a function of fibrin and platelet density. , 2013, Biophysical journal.

[104]  P. Reitsma,et al.  New fundamentals in hemostasis. , 2013, Physiological reviews.

[105]  R. Pinto,et al.  The utility of recombinant factor VIIa as a last resort in trauma , 2012, World Journal of Emergency Surgery.

[106]  J. Reifman,et al.  Therapeutic correction of thrombin generation in dilution-induced coagulopathy: Computational analysis based on a data set of healthy subjects , 2012, The journal of trauma and acute care surgery.

[107]  H. Hemker,et al.  Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay. , 2012, Clinical chemistry.

[108]  P. T. Onundarson,et al.  Recombinant factor VIIa as last‐resort treatment of desperate haemorrhage , 2012, Acta anaesthesiologica Scandinavica.

[109]  M. Cohen,et al.  Use of models in identification and prediction of physiology in critically ill surgical patients , 2012, The British journal of surgery.

[110]  K. Brohi,et al.  Acute traumatic coagulopathy , 2012, Current opinion in anaesthesiology.

[111]  K. Mann,et al.  Clotting factor deficiency in early trauma-associated coagulopathy. , 2011, The Journal of trauma.

[112]  E. Moore,et al.  The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength. , 2011, Journal of Surgical Research.

[113]  K. Mann Thrombin generation in hemorrhage control and vascular occlusion. , 2011, Circulation.

[114]  P. Collins,et al.  Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding , 2011, Journal of thrombosis and haemostasis : JTH.

[115]  T. Schuster,et al.  Enhanced Thrombin Generation After Cardiopulmonary Bypass Surgery , 2011, Anesthesia and analgesia.

[116]  C. Wade,et al.  Multiple levels of degradation diminish hemostatic potential of thawed plasma. , 2011, The Journal of trauma.

[117]  W. Chandler,et al.  TRANSFUSION PRACTICE: Thrombin generation in trauma patients , 2009, Transfusion.

[118]  D. Lane,et al.  The central role of thrombin in hemostasis , 2007, Journal of thrombosis and haemostasis : JTH.

[119]  K. Mann,et al.  The resuscitative fluid you choose may potentiate bleeding. , 2006, The Journal of trauma.

[120]  Thomas Orfeo,et al.  Models of blood coagulation. , 2006, Blood cells, molecules & diseases.

[121]  M. Braun,et al.  Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. , 2006, JAMA.

[122]  J. Holcomb,et al.  Independent contributions of hypothermia and acidosis to coagulopathy in swine. , 2005, The Journal of trauma.

[123]  W. Chandler,et al.  Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass. , 2003, Blood.

[124]  H. Coenraad Hemker,et al.  Calibrated Automated Thrombin Generation Measurement in Clotting Plasma , 2003, Pathophysiology of Haemostasis and Thrombosis.

[125]  M. Mosesson,et al.  Theme issue: Fibrinogen and fibrin – structure, function, interactions and clinical applications , 2003, Thrombosis and Haemostasis.

[126]  M. Mosesson Antithrombin I. Inhibition of thrombin generation in plasma by fibrin formation , 2003, Thrombosis and Haemostasis.