论文信息 - A Glutaric Acid Ester as Carrier System for Sustained Delivery of Lamuvidine (3TC) Dimers - 字舞流文

A Glutaric Acid Ester as Carrier System for Sustained Delivery of Lamuvidine (3TC) Dimers

We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.

J. Vasseur | J. Engels | J. Secrist | H. Lazrek

[1] J. Vasseur,et al. HOMO AND HETERODIMERS OF DDI, D4T AND AZT: INFLUENCE OF (5′-5′) THIOLCABONATE-CARBAMATE LINKAGE ON ANTI-HIV ACTIVITY , 2005, Nucleosides, nucleotides & nucleic acids.

[2] C. K. Chu,et al. Nucleoside and Nucleotide Prodrugs , 2003 .

[3] C. K. Chu. Recent Advances in Nucleosides: Chemistry and Chemotherapy , 2002 .

[4] C. K. Chu,et al. L-Nucleosides as chemotherapeutic agents. , 2001, FEMS microbiology letters.

[5] J. Chermann,et al. Inhibition of human immunodeficiency virus type 1 replication by phosphonoformate- and phosphonoacetate-2',3'-dideoxy-3'-thiacytidine conjugates. , 1994, Journal of medicinal chemistry.

[6] K. Agrawal,et al. Synthesis and biological evaluation of prodrugs of zidovudine. , 1990, Journal of medicinal chemistry.

[7] J. Chermann,et al. Detection and titration of neutralizing antibodies to HIV using an inhibition of the cytopathic effect of the virus on MT4 cells. , 1987, Journal of virological methods.