Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia

Background: Pre eclampsia is responsible for significant maternal and perinatal morbidity and mortality worldwide .Serum LDH level is a useful biomarker for cellular injury which may reflect the severity of pre eclampsia and its level might be a guideline for management of patients. The aim of study was to find out the role of serum LDH in prediction of adverse outcome of pre eclampsia, severity of disease and occurrence of complications.Methods: This prospective observational study was conducted in the department of Obstetrics and Gynecolog, RIMS, Ranchi, Jharkhand, India. A total of 300 cases were studied.150 cases were non severe preeclamptic and 150 cases were severe pre eclamptic patients. Serum LDH was done in both non severe and severe eclamptic patients .Data entry was done in Microsoft excel 2007. Results were analysed by chi square test.Results: Higher LDH levels had significant correlation with high blood pressure as well as poor maternal and perinatal outcome.Conclusions: High serum LDH level correlate well with the severity of disease and poor outcome in patients of pre eclampsia. Detection of high risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

[1]  R. Kaur,et al.  SIGNIFICANCE OF LACTATE DEHYDROGENASE AND ASPARTATE TRANSAMINASE AS BIOCHEMICAL MARKERS AND AS PREDICTORS OF SEVERITY OF PREGNANCY-INDUCED HYPERTENSION AND ITS COMPLICATIONS , 2017 .

[2]  Lata Rajoria,et al.  Serum LDH in Preeclampsia & Eclampsia and Maternal Outcomes , 2016 .

[3]  S. Sultana,et al.  Serum Lactate Dehydrogenase (LDH) Level in Severe Preeclampsia , 2016 .

[4]  N. Jha,et al.  Study on serum lactate dehydrogenase (LDH) as a biochemical marker for maternal and perinatal outcome in preeclampsia and eclampsia , 2015 .

[5]  J. Hak,et al.  LDH Levels in Pregnancy and its Association with Severity of the Disease and Feto-maternal Outcome in Pre-eclampsia and Eclampsia. , 2015 .

[6]  Amrit Gupta,et al.  Lactic Dehydrogenase: A Biochemical Marker for Preeclampsia–Eclampsia , 2011, Journal of obstetrics and gynaecology of India.

[7]  Z. Amarin,et al.  Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia. , 2005, Medical science monitor : international medical journal of experimental and clinical research.

[8]  J. N. Martin,et al.  Early risk assessment of severe preeclampsia: admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity. , 1999, American journal of obstetrics and gynecology.

[9]  P. Sarkar,et al.  Evaluation of serum lactate dehydrogenase and gamma glutamyl transferase in preeclamptic pregnancy and its comparison with normal pregnancy in third trimester , 2013 .

[10]  A. Sonagra,et al.  SERUM LDH , ALP AND URIC ACID IN HYPERTENSIVE DISORDERS OF PREGNANCY , 2012 .

[11]  T. Mahboob,et al.  RELATION BETWEEN PREECLAMPSIA AND CARDIAC ENZYMES , 2008 .

[12]  M. Blombäck,et al.  Increased concentrations of lactate dehydrogenase in pregnancy with preeclampsia: a predictor for the birth of small-for-gestational-age infants. , 1995, Gynecologic and obstetric investigation.