Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
暂无分享,去创建一个
P. Howarth | Susan J Wilson | S. Holgate | D. Davies | H. Haitchi | J. Holloway | Suresh K Babu | S. Wilson | Suresh Babu
[1] C. Baena-Cagnani,et al. Asthma mortality, inhaled steroids, and changing asthma therapy in Argentina (1990-1999). , 2006, Respiratory medicine.
[2] H. Bibi,et al. Do current treatment protocols adequately prevent airway remodeling in children with mild intermittent asthma? , 2006, Respiratory medicine.
[3] I. Pavord,et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. , 2006, The New England journal of medicine.
[4] J. Vonk,et al. Predicting adult asthma in childhood , 2006, Current opinion in pulmonary medicine.
[5] C. Colás,et al. Effect of Omalizumab on Adenosine 5′-Monophosphate Responsiveness in Subjects with Allergic Asthma , 2006, International Archives of Allergy and Immunology.
[6] J. Siddiqui,et al. Anti‐tumor necrosis factor‐α antibody treatment reduces pulmonary inflammation and methacholine hyper‐responsiveness in a murine asthma model induced by house dust , 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[7] F. Martinez. Safety of long-acting beta-agonists--an urgent need to clear the air. , 2005, The New England journal of medicine.
[8] P. Howarth,et al. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. , 2005, Thorax.
[9] D. Wakefield,et al. Risk factors for asthma and asthma severity in nonurban children in Connecticut. , 2005, Chest.
[10] D. Postma,et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex , 2005, Thorax.
[11] Stefano Guerra,et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. , 2005, American journal of respiratory and critical care medicine.
[12] Q. Hamid,et al. Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide. , 2005, The Journal of allergy and clinical immunology.
[13] S. Holgate,et al. ADAM33: a newly identified gene in the pathogenesis of asthma. , 2005, Immunology and allergy clinics of North America.
[14] C. Janson,et al. Are the Asthma Guideline Goals Achieved in Daily Practice? A Population-Based Study on Treatment Adequacy and the Control of Asthma , 2005, International Archives of Allergy and Immunology.
[15] I. Tillie‐Leblond,et al. High-resolution computed tomography scan and airway remodeling in children with severe asthma. , 2005, The Journal of allergy and clinical immunology.
[16] G. Currie,et al. Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma? , 2005, Chest.
[17] M. Rosenthal,et al. Tumour necrosis factor gene polymorphisms and childhood wheezing , 2005, European Respiratory Journal.
[18] P. Sterk,et al. Bronchial CD8 cell infiltrate and lung function decline in asthma. , 2005, American journal of respiratory and critical care medicine.
[19] Judith M. White,et al. Selective modulation of integrin-mediated cell migration by distinct ADAM family members. , 2005, Molecular biology of the cell.
[20] B. Harrison,et al. Difficult asthma in adults: recognition and approaches to management , 2005, Internal medicine journal.
[21] R. Scott,et al. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. , 2005, American journal of respiratory and critical care medicine.
[22] Q. Hamid,et al. Role of airway smooth muscle in airway remodeling. , 2005, The Journal of allergy and clinical immunology.
[23] M. Stylianou,et al. Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation. , 2005, Respiratory medicine.
[24] G. Walsh. Novel therapies for asthma--advances and problems. , 2005, Current pharmaceutical design.
[25] V. Siroux,et al. Asthma severity and exposure to occupational asthmogens. , 2005, American journal of respiratory and critical care medicine.
[26] D. Postma,et al. A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. , 2005 .
[27] S. Holgate. The Quintiles Prize Lecture 2004: The identification of the adenosine A2B receptor as a novel therapeutic target in asthma , 2005, British journal of pharmacology.
[28] A. Burks,et al. Omalizumab : other indications and unanswered questions. , 2005, Clinical reviews in allergy & immunology.
[29] D. Duffy,et al. A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women , 2005, Thorax.
[30] S. Wenzel,et al. Severe asthma in adults. , 2005, American journal of respiratory and critical care medicine.
[31] A. Woodcock,et al. Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. , 2005, American journal of respiratory and critical care medicine.
[32] I. Adcock,et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. , 2005, The New England journal of medicine.
[33] J. Ioannidis,et al. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. , 2005, The Journal of allergy and clinical immunology.
[34] David I. Wilson,et al. ADAM33 expression in asthmatic airways and human embryonic lungs. , 2005, American journal of respiratory and critical care medicine.
[35] S. Holgate,et al. Epithelial stress and structural remodelling in childhood asthma , 2005, Thorax.
[36] J. Bousquet,et al. Anti‐immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti‐inflammatory activity and clinical efficacy , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[37] T. Haahtela,et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. , 2005, American journal of respiratory and critical care medicine.
[38] I. Hall,et al. Contribution of ADAM33 polymorphisms to the population risk of asthma , 2005, Thorax.
[39] J. Bousquet,et al. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. , 2005, The Journal of allergy and clinical immunology.
[40] J Bousquet,et al. Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE , 2005, Allergy.
[41] Lance C Bridges,et al. ADAM-Integrin Interactions: potential integrin regulated ectodomain shedding activity. , 2005, Current pharmaceutical design.
[42] Jun Zou,et al. ADAM33 enzyme properties and substrate specificity. , 2005, Biochemistry.
[43] K. Chung,et al. Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. , 2005, Respiratory medicine.
[44] J. Warner,et al. Markers of eosinophilic inflammation and tissue re‐modelling in children before clinically diagnosed bronchial asthma , 2005, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
[45] D. Price,et al. The national montelukast survey. , 2005, The Journal of allergy and clinical immunology.
[46] E. Rönmark,et al. Different Labelling of Obstructive Airway Diseases in Estonia, Finland, and Sweden , 2005, European Journal of Epidemiology.
[47] D. Hyde,et al. Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[48] A. Bush,et al. Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms , 2004, Thorax.
[49] Stephen T Holgate,et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. , 2004, American journal of respiratory and critical care medicine.
[50] I. Adcock,et al. Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. , 2004, American journal of respiratory and critical care medicine.
[51] P. Barnes,et al. Parameters associated with persistent airflow obstruction in chronic severe asthma , 2004, European Respiratory Journal.
[52] P. Woodruff,et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. , 2004, American journal of respiratory and critical care medicine.
[53] C. Bucca,et al. Asthma severity and medical resource utilisation , 2004, European Respiratory Journal.
[54] L. Palmer,et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. , 2004, American journal of respiratory and critical care medicine.
[55] Maree H. Poniris,et al. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. , 2004, The Journal of allergy and clinical immunology.
[56] J. Bousquet,et al. Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma. , 2004, Chest.
[57] Jun Zou,et al. Catalytic Activity of Human ADAM33* , 2004, Journal of Biological Chemistry.
[58] C. Walker,et al. Induction of TNF-α Autoantibody Production by AutoVac TNF106: A Novel Therapeutic Approach for the Treatment of Allergic Diseases , 2004, International Archives of Allergy and Immunology.
[59] S. Holgate,et al. The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts. , 2004, American journal of respiratory cell and molecular biology.
[60] L. Palmer,et al. Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. , 2004, American journal of respiratory and critical care medicine.
[61] Jun Zou,et al. Crystal structure of the catalytic domain of human ADAM33. , 2004, Journal of molecular biology.
[62] P. Barnes. Corticosteroid resistance in airway disease. , 2004, Proceedings of the American Thoracic Society.
[63] P. Jeffery. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. , 2004, Proceedings of the American Thoracic Society.
[64] I. Adcock,et al. Combination Therapy of Long-Acting β2-Adrenoceptor Agonists and Corticosteroids for Asthma , 2004, Treatments in respiratory medicine.
[65] M. Mishima,et al. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. , 2003, American journal of respiratory and critical care medicine.
[66] Phil A. Silva,et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. , 2003, The New England journal of medicine.
[67] M. Feldmann,et al. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases , 2003, Nature Medicine.
[68] J. Fredberg,et al. Remodeling of the airway smooth muscle cell: are we built of glass? , 2003, Respiratory Physiology & Neurobiology.
[69] D. Postma,et al. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma , 2003, European Respiratory Journal.
[70] P. Macklem,et al. Airway wall remodeling: friend or foe? , 2003, Journal of applied physiology.
[71] L. Boulet,et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. , 2003, The Journal of allergy and clinical immunology.
[72] Jun Zou,et al. Human ADAM33 messenger RNA expression profile and post-transcriptional regulation. , 2003, American journal of respiratory cell and molecular biology.
[73] M. Aubier,et al. Airway structural alterations selectively associated with severe asthma. , 2003, American journal of respiratory and critical care medicine.
[74] T. Harris,et al. Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle , 2003, Clinical and experimental pharmacology & physiology.
[75] William W Busse,et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial , 2003, The Lancet.
[76] D. Hyde,et al. The effect of house dust mite aeroallergen and air pollutant exposures during infancy. , 2003, Chest.
[77] J. McConville,et al. What evidence implicates airway smooth muscle in the cause of BHR? , 2003, Clinical reviews in allergy & immunology.
[78] S. Holgate,et al. Airway remodeling in asthma: new insights. , 2003, The Journal of allergy and clinical immunology.
[79] H. Windom,et al. Omalizumab improves asthma-related quality of life in patients with severe allergic asthma. , 2003, The Journal of allergy and clinical immunology.
[80] P. Howarth,et al. Pharmacotherapy and airway remodelling in asthma? , 2003, Thorax.
[81] Jeffrey M Drazen,et al. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. , 2003, American journal of respiratory cell and molecular biology.
[82] Jun Zou,et al. Human ADAM33: protein maturation and localization. , 2003, Biochemical and biophysical research communications.
[83] L. Boulet,et al. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. , 2002, The international journal of biochemistry & cell biology.
[84] P. Thomas,et al. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma , 2002, Thorax.
[85] P. Howarth,et al. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. , 2002, American journal of respiratory cell and molecular biology.
[86] Steuart Rorke,et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness , 2002, Nature.
[87] Susan J Wilson,et al. Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells1 , 2002, The Journal of Immunology.
[88] A. Woodcock,et al. Specific airway resistance in 3-year-old children: a prospective cohort study , 2002, The Lancet.
[89] I. Adcock,et al. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. , 2002, The Journal of allergy and clinical immunology.
[90] K. J. Macleod,et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma , 2002, Thorax.
[91] P. Gibson,et al. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma , 2002, European Respiratory Journal.
[92] R. Pauwels,et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. , 2002, American journal of respiratory and critical care medicine.
[93] D. Johns,et al. Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. , 2001, American journal of respiratory and critical care medicine.
[94] J. Cidlowski,et al. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[95] P. Thomas. Tumour necrosis factor‐α: The role of this multifunctional cytokine in asthma , 2001 .
[96] W. Busse,et al. Pathophysiology of severe asthma. , 2000, The Journal of allergy and clinical immunology.
[97] M. Aldrich,et al. Modulation of allergic inflammation in mice deficient in TNF receptors. , 2000, American journal of physiology. Lung cellular and molecular physiology.
[98] N Franklin Adkinson,et al. Long-term effects of budesonide or nedocromil in children with asthma. , 2000, The New England journal of medicine.
[99] J. Spinelli,et al. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. , 2000, The Journal of allergy and clinical immunology.
[100] D. Johns,et al. Airway distensibility in healthy and asthmatic subjects: effect of lung volume history. , 2000, Journal of applied physiology.
[101] H. Bisgaard. Long‐acting β2‐agonists in management of childhood asthma: A critical review of the literature , 2000 .
[102] Britton,et al. Association between − 308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[103] J. Lafitte,et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. , 1999, American journal of respiratory and critical care medicine.
[104] V. Plaza,et al. Costs of asthma according to the degree of severity. , 1998, The European respiratory journal.
[105] J. Westwick,et al. Airway inflammation induced by recombinant guinea pig tumor necrosis factor-alpha. , 1997, The American journal of physiology.
[106] R. Djukanović,et al. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics. , 1997, The Journal of clinical investigation.
[107] S. Holgate,et al. Tumour necrosis factor alpha: a polcnlial mediator of asthma , 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[108] D. Yates,et al. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. , 1995, American journal of respiratory and critical care medicine.
[109] Melinda Fitzgerald,et al. Immunol. Cell Biol. , 1995 .
[110] M. Hibbert,et al. Outcome of childhood asthma in mid-adult life , 1994, BMJ.
[111] P. Howarth,et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. , 1994, American journal of respiratory cell and molecular biology.
[112] R. Pauwels,et al. Tumor necrosis factor causes bronchial hyperresponsiveness in rats. , 1992, The American review of respiratory disease.
[113] P. Howarth,et al. Myofibroblasts and subepithelial fibrosis in bronchial asthma. , 1990, American journal of respiratory cell and molecular biology.
[114] S. Holgate,et al. SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS , 1989, The Lancet.
[115] A. Cats,et al. HL-A 27 AND ANKYLOSING SPONDYLITIS , 1975, The Lancet.