Novel quinolone substituted thiazolidin-4-ones as anti-inflammatory, anticancer agents: design, synthesis and biological screening.

[1]  R. Gambari,et al.  Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects. , 2011, European journal of medicinal chemistry.

[2]  L. Wiesmüller,et al.  NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes , 2011, Nucleic acids research.

[3]  R. Gambari,et al.  Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis. , 2010, Bioorganic & medicinal chemistry.

[4]  Yingnan Yang,et al.  Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells. , 2010, Chinese medical journal.

[5]  S. Im,et al.  Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1 , 2010, BMC Cancer.

[6]  Stefano Forli,et al.  Virtual screening with AutoDock: theory and practice , 2010, Expert opinion on drug discovery.

[7]  R. Gambari,et al.  Virtual Screening against p50 NF‐κB Transcription Factor for the Identification of Inhibitors of the NF‐κB–DNA Interaction and Expression of NF‐κB Upregulated Genes , 2009, ChemMedChem.

[8]  L. S. Yazan,et al.  Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. , 2009, Cancer epidemiology.

[9]  Johanna M Jansen,et al.  Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. , 2009, Journal of medicinal chemistry.

[10]  B. Aggarwal,et al.  Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis , 2008, Molecular Cancer Research.

[11]  S. Saraf,et al.  4-thiazolidinone--a biologically active scaffold. , 2008, European journal of medicinal chemistry.

[12]  Antonio Morreale,et al.  Structure-Based Discovery of Novel Non-nucleosidic DNA Alkyltransferase Inhibitors: Virtual Screening and in Vitro and in Vivo Activities , 2008, J. Chem. Inf. Model..

[13]  Jai-Sing Yang,et al.  Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). , 2008, Anticancer research.

[14]  Vladimir V Poroikov,et al.  Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition. , 2008, Journal of medicinal chemistry.

[15]  V. Revankar,et al.  Synthesis, Structure, Electrochemistry, and Spectral Characterization of Bis-Isatin Thiocarbohydrazone Metal Complexes and Their Antitumor Activity Against Ehrlich Ascites Carcinoma in Swiss Albino Mice , 2007, Metal-based drugs.

[16]  A. Griffioen,et al.  A new role for NF-κB in angiogenesis inhibition , 2007, Cell Death and Differentiation.

[17]  G. Melagraki,et al.  Design and Synthesis of Novel Quinolinone-3-aminoamides and Their α-Lipoic Acid Adducts as Antioxidant and Anti-inflammatory Agents , 2007 .

[18]  A. Cavalli,et al.  Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects. , 2006, Journal of medicinal chemistry.

[19]  K. Priyadarsini,et al.  Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and alpha-lipoic acid. , 2006, Bioorganic & medicinal chemistry.

[20]  M. A. Sridhar,et al.  Synthesis of new bioactive venlafaxine analogs: novel thiazolidin-4-ones as antimicrobials. , 2006, Bioorganic & medicinal chemistry.

[21]  M. Alexis,et al.  Chroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damage. , 2006, Journal of medicinal chemistry.

[22]  D. Zaharevitz,et al.  A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. , 2005, Journal of medicinal chemistry.

[23]  S. Menichetti,et al.  Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans. , 2005, Organic & biomolecular chemistry.

[24]  C. Lartigue,et al.  New 3- and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents. , 2005, Bioorganic & medicinal chemistry.

[25]  R. Mirimanoff,et al.  MGMT gene silencing and benefit from temozolomide in glioblastoma. , 2005, The New England journal of medicine.

[26]  Duane D. Miller,et al.  Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. , 2005, Journal of medicinal chemistry.

[27]  V. Tumiatti,et al.  Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds. , 2005, Journal of medicinal chemistry.

[28]  W. Humphreys,et al.  Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. , 2005, Journal of medicinal chemistry.

[29]  B. Aggarwal,et al.  Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation , 2004, Oncogene.

[30]  Archana.,et al.  Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents. , 2003, Bioorganic & medicinal chemistry.

[31]  T. Lightfoot,et al.  Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells , 2003, British Journal of Cancer.

[32]  Yi Xia,et al.  Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters. , 2003, Bioorganic & medicinal chemistry.

[33]  H. Padh,et al.  Novel drug designing approach for dual inhibitors as anti-inflammatory agents: implication of pyridine template. , 2003, Biochemical and biophysical research communications.

[34]  L. Coussens,et al.  Inflammation and cancer , 2002, Nature.

[35]  S. Marumoto,et al.  Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease. , 2002, Organic letters.

[36]  P. Chabrier,et al.  Novel lipoic acid analogues that inhibit nitric oxide synthase. , 2002, Bioorganic & medicinal chemistry letters.

[37]  G. Raj,et al.  Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. , 2002, The Journal of urology.

[38]  G. Garrido,et al.  Analgesic and anti‐inflammatory effects of Mangifera indica L. extract (Vimang) , 2001, Phytotherapy research : PTR.

[39]  Scar,et al.  Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. , 2000, The New England journal of medicine.

[40]  L. Wang,et al.  Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. , 1994, Biochemical and biophysical research communications.

[41]  K. Faber,et al.  Non‐steroidal antiinflammatory agents. 2. Synthesis of 4‐hydroxy‐1‐methyl‐2‐oxo‐dihydroquinolin‐3‐yl acetic acid and related tetrazolyl derivatives , 1984 .

[42]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[43]  C A WINTER,et al.  Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[44]  Didier Rognan,et al.  The practice of medicinal chemistry , 2015 .

[45]  V. Revankar,et al.  Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice. , 2010, European journal of medicinal chemistry.

[46]  Y. Naito,et al.  Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study. , 1995, Free radical biology & medicine.