Keratin alterations could be an early event of wrinkle formation.

[1]  G. Imokawa Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase , 2008, Archives of Dermatological Research.

[2]  T. Fujimura,et al.  The formation of wrinkles caused by transition of keratin intermediate filaments after repetitive UVB exposure , 2005, Archives of Dermatological Research.

[3]  F. Bernerd,et al.  Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice , 2004, The British journal of dermatology.

[4]  P. Coulombe,et al.  Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair , 2003, The Journal of cell biology.

[5]  D. Wirtz,et al.  A 'hot-spot' mutation alters the mechanical properties of keratin filament networks , 2001, Nature Cell Biology.

[6]  P. Coulombe,et al.  Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin , 1994, The Journal of cell biology.

[7]  K. Shuai,et al.  Disease-activated transcription factor: allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17 , 1994, Molecular and cellular biology.

[8]  H I Maibach,et al.  Measurement of the transit time for cells through the epidermis and stratum corneum of the mouse and guinea‐pig , 1987, Cell and tissue kinetics.

[9]  Y. Asada,et al.  The effect of ultraviolet radiation on the water-reservoir functions of the stratum corneum. , 1992, Photodermatology, photoimmunology & photomedicine.