Integrated real‐time Raman system for clinical in vivo skin analysis

Background: Raman spectroscopy is a non‐invasive optical technique that can probe the molecular structure and conformation of biochemical constituents. The probability of Raman scattering is exceedingly low (∼10−10), and consequently up to now the practical application of Raman spectroscopy to clinical medicine has been limited by either the weak spectral signal or by the long data acquisition times. Recent advances in Raman hardware and probe design have reduced spectral acquisition times, paving the way for clinical applications.

[1]  E. Sevick-Muraca,et al.  Quantitative optical spectroscopy for tissue diagnosis. , 1996, Annual review of physical chemistry.

[2]  D I McLean,et al.  Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements. , 2001, Optics letters.

[3]  Andrew Jirasek,et al.  Investigation of Selected Baseline Removal Techniques as Candidates for Automated Implementation , 2005, Applied spectroscopy.

[4]  Michele Follen,et al.  Calibration standards for multicenter clinical trials of fluorescence spectroscopy for in vivo diagnosis. , 2006, Journal of biomedical optics.

[5]  R. Dasari,et al.  Diagnosing breast cancer by using Raman spectroscopy. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Brian W. Barry,et al.  Potential applications of FT-Raman spectroscopy for dermatological diagnostics , 1995 .

[7]  James L Lambert,et al.  Glucose determination in human aqueous humor with Raman spectroscopy. , 2005, Journal of biomedical optics.

[8]  D. McLean,et al.  Automated Autofluorescence Background Subtraction Algorithm for Biomedical Raman Spectroscopy , 2007, Applied spectroscopy.

[9]  N Stone,et al.  Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer. , 2005, Urology.

[10]  N. Ramanujam,et al.  Development of a Fiber Optic Probe to Measure NIR Raman Spectra of Cervical Tissue In Vivo , 1998, Photochemistry and photobiology.

[11]  David E. Battey,et al.  New spectroscopic instrument based on volume holographic optical elements , 1995, Electronic Imaging.

[12]  Howell G. M. Edwards,et al.  Fourier transform Raman and infrared vibrational study of human skin: Assignment of spectral bands , 1992 .

[13]  Georgios N Stamatas,et al.  Optical non-invasive approaches to diagnosis of skin diseases. , 2002, The journal of investigative dermatology. Symposium proceedings.

[14]  C. MacAulay,et al.  The Dynamics of Laser‐Induced Changes in Human Skin Autofluorescence—Experimental Measurements and Theoretical Modeling , 1998, Photochemistry and photobiology.

[15]  A. Mahadevan-Jansen,et al.  Automated Method for Subtraction of Fluorescence from Biological Raman Spectra , 2003, Applied spectroscopy.

[16]  Christopher J. Frank,et al.  Raman spectroscopy of normal and diseased human breast tissues. , 1995, Analytical chemistry.

[17]  Michael L. Wach,et al.  In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy. , 2000, Analytical chemistry.

[18]  Pavel Matousek,et al.  Kerr-gated time-resolved Raman spectroscopy of equine cortical bone tissue. , 2005, Journal of biomedical optics.

[19]  M. Feld,et al.  Raman spectroscopy for noninvasive glucose measurements. , 2005, Journal of biomedical optics.

[20]  H. Bruining,et al.  In vitro and in vivo Raman spectroscopy of human skin. , 1998, Biospectroscopy.

[21]  B. Wilson,et al.  The Effects of ex vivo Handling Procedures on the Near‐Infrared Raman Spectra of Normal Mammalian Tissues , 1996, Photochemistry and photobiology.

[22]  Gerwin J. Puppels,et al.  Real-time tissue characterization on the basis of in vivo Raman spectra , 2002 .

[23]  R. Richards-Kortum,et al.  Raman spectroscopy for the detection of cancers and precancers. , 1996, Journal of biomedical optics.

[24]  Haishan Zeng,et al.  Cutaneous melanin exhibiting fluorescence emission under near-infrared light excitation. , 2006, Journal of biomedical optics.

[25]  R. McCreery,et al.  Noninvasive identification of materials inside USP vials with Raman spectroscopy and a Raman spectral library. , 1998, Journal of pharmaceutical sciences.

[26]  G. Puppels,et al.  Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. , 2003, Biophysical journal.

[27]  Haishan Zeng,et al.  Raman Spectroscopy in Combination with Background Near-infrared Autofluorescence Enhances the In Vivo Assessment of Malignant Tissues , 2005, Photochemistry and photobiology.

[28]  C. Hadjur,et al.  In vivo chemical investigation of human skin using a confocal Raman fiber optic microprobe. , 2005, Journal of biomedical optics.

[29]  B. Wilson,et al.  Development of an In Vivo Raman Spectroscopic System for Diagnostic Applications , 1997 .

[30]  Haishan Zeng,et al.  Raman spectroscopy of in vivo cutaneous melanin. , 2004, Journal of biomedical optics.

[31]  R. Dhillon,et al.  For the safe use of lasers , 1989 .

[32]  R. Dasari,et al.  Prospects for in vivo Raman spectroscopy , 2000 .

[33]  Abigail S Haka,et al.  Real-time Raman system for in vivo disease diagnosis. , 2005, Journal of biomedical optics.

[34]  R. Alfano,et al.  Human breast tissues studied by IR Fourier-transform Raman spectroscopy , 1991 .

[35]  William Montagna,et al.  Atlas of Normal Human Skin , 1992, Springer New York.

[36]  S. Lam,et al.  Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissues. , 2003, International journal of oncology.

[37]  Abigail S Haka,et al.  In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque. , 2006, Journal of biomedical optics.

[38]  R. Richards-Kortum,et al.  Near-Infrared Raman Spectroscopy for in vivo Detection of Cervical Precancers , 2001, Photochemistry and photobiology.

[39]  S. Lam,et al.  Near‐infrared Raman spectroscopy for optical diagnosis of lung cancer , 2003, International journal of cancer.