Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer
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J. Iovanna | N. Dusetti | O. Larsson | C. Jean | S. Rocchi | Y. Martineau | C. Bousquet | S. Pyronnet | C. Neuzillet | C. Joffre | R. Nicolle | M. Ayadi | J. Raffenne | R. Samain | Sauyeun Shin | A. Brunel | J. Solórzano | Jacobo Solórzano | Carine Joffre
[1] J. Mancias,et al. Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer , 2020, Cell.
[2] L. Matrisian,et al. Projection of cancer incidence and death to 2040 in the US: Impact of cancer screening and a changing demographic. , 2020 .
[3] N. Malats,et al. Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses , 2020, Gut.
[4] E. O’Reilly,et al. New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma , 2020, Drugs.
[5] Stephen A. Sastra,et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice , 2020, Science.
[6] T. Nägele,et al. Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation , 2019, Cell reports.
[7] C. Tournigand,et al. Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: An open-label, randomized Phase IIb trial. , 2019, European journal of cancer.
[8] N. Sonenberg,et al. eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer. , 2019, JCI insight.
[9] E. Ruppin,et al. Translational Reprogramming Marks Adaptation to Asparagine Restriction in Cancer , 2019, Nature Cell Biology.
[10] S. Sivanand,et al. Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. , 2019, Cell metabolism.
[11] Joon-Oh Park,et al. Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. , 2019, The New England journal of medicine.
[12] Dae Cheon Jeong,et al. Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma , 2019, OncoTargets and therapy.
[13] O. Larsson,et al. Generally applicable transcriptome-wide analysis of translation using anota2seq , 2019, Nucleic acids research.
[14] Jeffrey E. Lee,et al. Expression and Clinical Significance of Protein Kinase RNA–Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2&agr; in Pancreatic Ductal Adenocarcinoma , 2019, Pancreas.
[15] P. Walter,et al. Small molecule ISRIB suppresses the integrated stress response within a defined window of activation , 2019, Proceedings of the National Academy of Sciences.
[16] R. Nishigaki,et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response , 2018, Proceedings of the National Academy of Sciences.
[17] L. Parts,et al. Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B , 2018, Science.
[18] Kwok-Kin Wong,et al. Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. , 2018, Cancer discovery.
[19] O. Elroy-Stein,et al. A Unique ISR Program Determines Cellular Responses to Chronic Stress. , 2017, Molecular cell.
[20] J. Iovanna,et al. Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts , 2017, Cell reports.
[21] Jingqin Luo,et al. Tissue‐Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression , 2017, Immunity.
[22] M. V. Vander Heiden,et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions , 2017, Nature Communications.
[23] S. Gallinger,et al. Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer , 2017, British Journal of Cancer.
[24] O. Larsson,et al. Polysome-profiling in small tissue samples , 2017, bioRxiv.
[25] Agnieszka K Witkiewicz,et al. Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility , 2017, Gut.
[26] Jingqin Luo,et al. Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression. , 2017, Immunity.
[27] Mila Ljujic,et al. The integrated stress response , 2016, EMBO reports.
[28] Karen H. Vousden,et al. Serine and one-carbon metabolism in cancer , 2016, Nature Reviews Cancer.
[29] Masato Miyake,et al. Integrated stress response of vertebrates is regulated by four eIF2α kinases , 2016, Scientific Reports.
[30] Brandon Da Silva,et al. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer , 2016, Cell.
[31] P. Abbe,et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. , 2016, Cancer cell.
[32] Nicholas T. Ingolia. Ribosome Footprint Profiling of Translation throughout the Genome , 2016, Cell.
[33] Christian M. Metallo,et al. Branched chain amino acid catabolism fuels adipocyte differentiation and lipogenesis , 2015, Nature chemical biology.
[34] H. A. King,et al. Translatome profiling: methods for genome-scale analysis of mRNA translation. , 2014, Briefings in functional genomics.
[35] P. Abbe,et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. , 2016, Cancer cell.
[36] M. Korc,et al. Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma , 2015, Cell Death and Disease.
[37] Jen Jen Yeh,et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma , 2015, Nature Genetics.
[38] N. Sonenberg,et al. Targeting the translation machinery in cancer , 2015, Nature Reviews Drug Discovery.
[39] C. Weekes,et al. Nanoparticle albumin-bound (nab)-paclitaxel for the treatment of pancreas ductal adenocarcinoma , 2015 .
[40] K. Vousden,et al. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. , 2014, Cell reports.
[41] Amy Y. M. Au,et al. Targeting mTOR dependency in pancreatic cancer , 2014, Gut.
[42] J. Pelletier,et al. Pancreatic tumours escape from translational control through 4E-BP1 loss , 2014, Oncogene.
[43] 徐凤鸣. Branched chain amino acid , 2013 .
[44] V. Carraro,et al. The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression , 2013, Nucleic acids research.
[45] Brent M. Sanders,et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. , 2013, Cancer research.
[46] J. Scoazec,et al. Pancreatic Tumor Sensitivity to Plasma L-Asparagine Starvation , 2012, Pancreas.
[47] J. Rabinowitz,et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation , 2012, Proceedings of the National Academy of Sciences.
[48] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[49] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[50] M. Goggins,et al. Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. , 2003, Journal of the National Cancer Institute.