Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.
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T. Hökfelt | C. Wahlestedt | J. Skouv | J. Wengel | F. Porreca | P. Salmi | A. Koshkin | M. Ossipov | J. Lai | H. Oerum | L. Good | F Porreca | T Hökfelt | C. Broberger | C Wahlestedt | C Broberger | T. Johnsson | P Salmi | L Good | J Kela | T Johnsson | J Lai | K Ren | M Ossipov | A Koshkin | N Jakobsen | J Skouv | H Oerum | M H Jacobsen | J Wengel | J. Lai | J. Kela | Thomas Johnsson | K. Ren | M. Jacobsen | N. Jakobsen | Kunkun Ren | Nana Jakobsen
[1] V. Hruby,et al. Characterization of supraspinal antinociceptive actions of opiod delta agonists in the rat , 1995, Pain.
[2] E. Golanov,et al. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions , 1993, Nature.
[3] A. Branch,et al. A good antisense molecule is hard to find , 1998 .
[4] L. Shenkman,et al. Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line. , 1980, Molecular pharmacology.
[5] R. Rothman,et al. Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo. , 1996, The Journal of pharmacology and experimental therapeutics.
[6] P. Schultz,et al. A biosynthetic approach for the incorporation of unnatural amino acids into proteins. , 1998, Methods in molecular biology.
[7] H. Engelhard,et al. Use of Antisense Vectors and Oligodeoxynucleotides in Neuro-Oncology , 1998, Pediatric Neurosurgery.
[8] Poul Nielsen,et al. LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition , 1998 .
[9] Poul Nielsen,et al. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition , 1998 .
[10] R. Wagner,et al. Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides , 1996 .
[11] C. Leumann,et al. Synthesis and Pairing Properties of Decanucleotides from (3′S,5′R)-2′-Deoxy-3′, 5′-ethanoβ-D-ribofuranosyladenine and -thymine† , 1993 .
[12] C. A. Stein,et al. Keeping the biotechnology of antisense in context , 1999, Nature Biotechnology.
[13] G. Pasternak,et al. Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor , 1994, Neuron.
[14] C Wahlestedt,et al. Antisense oligonucleotides - the way forward. , 1999, Current opinion in drug discovery & development.
[15] S. Agrawal,et al. Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects. , 1998, Bioorganic & medicinal chemistry letters.
[16] L. Kaczmarek,et al. Brain as a unique antisense environment. , 1999, Antisense & nucleic acid drug development.
[17] C. O'callaghan,et al. Novel Method for Detection of β-Lactamases by Using a Chromogenic Cephalosporin Substrate , 1972, Antimicrobial Agents and Chemotherapy.
[18] C. Wahlestedt,et al. Antisense oligonucleotide strategies in neuropharmacology. , 1994, Trends in pharmacological sciences.
[19] K. Altmann,et al. 4′,6′-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides , 1994 .
[20] C. Olsen,et al. A Novel Class of Oligonucleotide Analogues Containing 2'-O,3'-C-Linked [3.2.0]Bicyclo-arabinonucleoside Monomers: Synthesis, Thermal Affinity Studies and Molecular Modelling , 1998 .
[21] T. Yaksh,et al. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. , 1977, The Journal of pharmacology and experimental therapeutics.
[22] T. Hökfelt,et al. Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain. , 2000, Brain research. Molecular brain research.
[23] J. Kampine,et al. Antisense oligodeoxynucleotide to a δ-opioid receptor selectivily blocks the spinal antinociception induced by δ-, but not μ- or κ-opioid receptor agonists in the mouse , 1994 .
[24] J. Wengel. Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA) , 1999 .
[25] P. Nielsen,et al. Applications of peptide nucleic acids. , 1999, Current opinion in biotechnology.
[26] Y. Hari,et al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-O,4'- C-methyleneribonucleosides , 1998 .
[27] P. Salmi,et al. Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat. , 1994 .
[28] E. Uhlmann. Peptide nucleic acids (PNA) and PNA-DNA chimeras: from high binding affinity towards biological function. , 1998, Biological chemistry.
[29] S. Crooke. Vitravene--another piece in the mosaic. , 1998, Antisense & nucleic acid drug development.
[30] C. Leumann,et al. Tricyclo-DNA: A phosphodiester-backbone based DNA analog exhibiting strong complementary base-pairing properties , 1997 .
[31] B. Kest,et al. An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice , 1996, Brain Research Bulletin.
[32] G. Koob,et al. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. , 1993, Science.
[33] G. Paxinos,et al. The Rat Brain in Stereotaxic Coordinates , 1983 .
[34] W. Zhang,et al. Modification of phosphorothioate oligonucleotides yields potent analogs with minimal toxicity for antisense experiments in the CNS. , 1998, Brain research. Molecular brain research.
[35] J. Wengel,et al. LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes , 1998 .