Orthogonally functionalizable polyacetals: a versatile platform for the design of acid sensitive amphiphilic copolymers

Dually functionalized amphiphilic copolyacetals as rational approach to the development of pH-responsive site-specific drug delivery systems.

[1]  A. Scala,et al.  Folate-Decorated Amphiphilic Cyclodextrins as Cell-Targeted Nanophototherapeutics. , 2019, Biomacromolecules.

[2]  A. Laschewsky,et al.  Ring-Opening Metathesis Polymerization of Biomass-Derived Levoglucosenol. , 2019, Angewandte Chemie.

[3]  Arif Z. Nelson,et al.  Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers. , 2019, Journal of the American Chemical Society.

[4]  Jiahui Yu,et al.  Rod-Shaped Micelles Based on PHF- g-(PCL-PEG) with pH-Triggered Doxorubicin Release and Enhanced Cellular Uptake. , 2019, Biomacromolecules.

[5]  V. Cádiz,et al.  Linear and branched acetal polymers from castor oil via acetal metathesis polymerization , 2018, European Polymer Journal.

[6]  Johannes C. Brendel,et al.  Smart pH-Sensitive Nanogels for Controlled Release in an Acidic Environment. , 2018, Biomacromolecules.

[7]  Jie He,et al.  A new design of cleavable acetal-containing amphiphilic block copolymers triggered by light , 2018, Journal of Polymer Science Part A: Polymer Chemistry.

[8]  M. Vicent,et al.  Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer. , 2018, Macromolecular rapid communications.

[9]  Xianzhu Yang,et al.  Acetal-Linked Hyperbranched Polyphosphoester Nanocarriers Loaded with Chlorin e6 for pH-Activatable Photodynamic Therapy. , 2018, ACS applied materials & interfaces.

[10]  Xuequan Zhang,et al.  Tumor-pH-Sensitive PLLA-Based Microsphere with Acid Cleavable Acetal Bonds on the Backbone for Efficient Localized Chemotherapy. , 2018, Biomacromolecules.

[11]  J. Koberstein,et al.  Main-chain polyacetal conjugates with HIF-1 inhibitors: temperature-responsive, pH-degradable drug delivery vehicles. , 2018, Journal of materials chemistry. B.

[12]  T. Endo,et al.  Reworkable Polyhydroxyurethane Films with Reversible Acetal Networks Obtained from Multifunctional Six-Membered Cyclic Carbonates. , 2018, Journal of the American Chemical Society.

[13]  Minna Hakkarainen,et al.  Designed to degrade , 2017, Science.

[14]  Fei Yang,et al.  Charge-reversible and pH-responsive biodegradable micelles and vesicles from linear-dendritic supramolecular amphiphiles for anticancer drug delivery , 2017 .

[15]  Derek L. Patton,et al.  Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization. , 2017, ACS macro letters.

[16]  B. Liu,et al.  Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels. , 2017, Journal of the American Chemical Society.

[17]  Jianjun Pan,et al.  Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria. , 2017, Biomacromolecules.

[18]  Srinivas Abbina,et al.  In Vivo Biological Evaluation of High Molecular Weight Multifunctional Acid-Degradable Polymeric Drug Carriers with Structurally Different Ketals. , 2016, Biomacromolecules.

[19]  Fei Yang,et al.  Facile synthesis and self-assembly behaviour of pH-responsive degradable polyacetal dendrimers , 2016 .

[20]  G. Guebitz,et al.  Hydrolytic degradation of ROMP thermosetting materials catalysed by bio-derived acids and enzymes: from networks to linear materials , 2016, 1603.03323.

[21]  J. Nicolas,et al.  Degradable vinyl polymers for biomedical applications. , 2015, Nature chemistry.

[22]  Zhiyuan Zhong,et al.  Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release. , 2015, Biomacromolecules.

[23]  V. Percec,et al.  A rational approach to activated polyacrylates and polymethacrylates by using a combination of model reactions and SET-LRP of hexafluoroisopropyl acrylate and methacrylate , 2015 .

[24]  A. Studer,et al.  Alternating copolymerization by nitroxide-mediated polymerization and subsequent orthogonal functionalization. , 2015, Angewandte Chemie.

[25]  Christopher E. Nelson,et al.  Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery , 2014, Biomacromolecules.

[26]  Mark M. Banaszak Holl,et al.  Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation , 2014, Biomacromolecules.

[27]  Liangfang Zhang,et al.  Current Advances in Polymer-Based Nanotheranostics for Cancer Treatment and Diagnosis , 2014, ACS applied materials & interfaces.

[28]  Robert J. Ono,et al.  Highly tunable polyurethanes: organocatalyzed polyaddition and subsequent post-polymerization modification of pentafluorophenyl ester sidechains , 2014 .

[29]  Wen‐Di Li,et al.  A degradable polycyclic cross-linker for UV-curing nanoimprint lithography , 2014 .

[30]  Jianhua Zhang,et al.  Comb-like amphiphilic copolymers bearing acetal-functionalized backbones with the ability of acid-triggered hydrophobic-to-hydrophilic transition as effective nanocarriers for intracellular release of curcumin. , 2013, Biomacromolecules.

[31]  M. Stenzel,et al.  Acid-degradable polymers for drug delivery: a decade of innovation. , 2013, Chemical communications.

[32]  Alexander G. Pemba,et al.  Acetal metathesis polymerization (AMP): A method for synthesizing biorenewable polyacetals , 2013 .

[33]  Youliang Zhao,et al.  Facile synthesis of ABCDE-type H-shaped quintopolymers by combination of ATRP, ROP, and click chemistry and their potential applications as drug carriers , 2012 .

[34]  V. Cádiz,et al.  Thiol–yne reaction of alkyne-derivatized fatty acids: biobased polyols and cytocompatibility of derived polyurethanes , 2012 .

[35]  Chi Wu,et al.  Formation Kinetics and Scaling of ``Defect-Free'' Hyperbranched Polystyrene Chains with Uniform Subchains Prepared from Seesaw-Type Macromonomers , 2011 .

[36]  H. Frey,et al.  PEG-based Multifunctional Polyethers with Highly Reactive Vinyl-Ether Side Chains for Click-Type Functionalization , 2011 .

[37]  D. Benoit,et al.  Synthesis of folate-functionalized RAFT polymers for targeted siRNA delivery. , 2011, Biomacromolecules.

[38]  R. Zentel,et al.  Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake. , 2010, Biomacromolecules.

[39]  C. Bowman,et al.  Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis. , 2010, Chemical Society reviews.

[40]  R. Broyer,et al.  Well‐defined polymers with acetal side chains as reactive scaffolds synthesized by atom transfer radical polymerization , 2006 .

[41]  C. S. Patrickios,et al.  Synthesis and characterization of polymer networks and star polymers containing a novel, hydrolyzable acetal-based dimethacrylate cross-linker , 2006 .

[42]  F. D. Du Prez,et al.  Thermoplastic polyacetals: chemistry from the past for a sustainable future? , 2019, Polymer Chemistry.

[43]  M. Vicent,et al.  pH-Responsive Polyacetal-Protein Conjugates Designed for Polymer Masked-Unmasked Protein Therapy (PUMPT). , 2018, Macromolecular bioscience.