Association of Neural Connectome With Early Experiences of Abuse in Adults

Key Points Question Is history of abuse associated with the intrinsic functional connectome of the adult brain independent of current psychiatric illness? Findings In this cohort study of 768 participants, individuals with abuse experienced during childhood (but not adolescence) demonstrated an altered connectome of greater functional connectivity associated with somatomotor and dorsal-ventral attention brain networks, irrespective of current diagnosis or symptom state. Meaning These findings suggest that a history of child abuse is associated with altered functioning of systems responsible for perceptual processing and attention, and these findings were transdiagnostic.

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