The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
暂无分享,去创建一个
David M. Wilson | A. Reith | F. King | A. Hird | Murray J. B. Brown | P. Lovell | A. Naylor | A. Takle | D. Dean | A. Gaiba | S. Davies | J. G. Steadman | Gerraint Francis | D. K. Dean
[1] J. McCubrey,et al. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). , 2003, International journal of oncology.
[2] G. Feuerstein,et al. Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis , 2003, Journal of Pharmacology and Experimental Therapeutics.
[3] D. Strumberg,et al. The Ras-Raf-MEK-ERK Pathway in the Treatment of Cancer , 2002, Oncology Research and Treatment.
[4] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[5] M. Moskowitz,et al. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[6] M. Cobb,et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.
[7] P. Cohen,et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .
[8] M. Salgaller. American Association for Cancer Research , 2000, Expert opinion on investigational drugs.
[9] A. Reith,et al. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. , 2000, Brain research. Molecular brain research.
[10] John C. Lee,et al. p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines. , 2001, Progress in medicinal chemistry.
[11] J. Boehm,et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. , 1997, Bioorganic & medicinal chemistry.