Dose and efficacy of repeated administrations of digoxin‐specific antibody fragments: Case report of foxglove poisoning

Digifab® is indicated for digoxin poisoning. One vial contains 40 mg of digoxin-specific antibody fragments (Fab) for intravenous administration. In cases of pharmaceutical digoxin poisoning, the necessary dose for complete neutralization is obtained by defined calculation. An empirical dose of 20 vials can be used in case of life-threatening poisoning without available serum digoxin level or estimation of amount ingested. Administration of initially 10 vials followed by 10 further vials is possible to avoid febrile reactions [1]. In cases of digoxin and cardiac glycosides plant poisoning, there are no official recommendations; the Digifab® dose administered is empirical.