Age-related changes in auditory potentials of mongolian gerbil

The Mongolian gerbil is being evaluated as an animal model of age-related hearing loss (presbyacusis). Part of this evaluation involves estimating auditory thresholds from evoked potentials arising from the auditory nerve and brainstem. The gerbils are born and reared in an environment where the ambient noise level is less than 40 dBA. Some animals are followed longitudinally (8, 19, 23.5 and 36 months), others are studied at 6-8 months (controls), or at 36 months (cross-sectional). Physiological responses are obtained with the animals anesthetized with ketamine and xylazine and transdermal electrodes attached to the head. Auditory signals are tone pips with center frequencies from 1 to 16 kHz in octave steps. Signal levels are varied from 10 to 80 dB SPL in 10 dB steps. For animals (N = 48) in the age range of 6-8 months, mean auditory thresholds were about 20 dB SPL between 2.0 and 8.0 kHz, 25 dB at 16 kHz and 30 dB at 1.0 kHz. By age 22-24 months (N = 15) thresholds had increased by about 10 dB at nearly all frequencies. By age 36 months (N = 37 ears, 32 animals) threshold increases were about 30-35 dB at 8 and 16 kHz, were 25 dB at 4 kHz and 2 kHz, and were 19 dB at 1 kHz. These hearing losses in 36-month gerbil are qualitatively similar to human data for 60-65-year-old males and 70-year-old females. Individual differences in hearing loss were large with the range exceeding 65 dB. While some animals (26/37) had a high-frequency sloping loss, others (11/37) had a bimodal audiometric shape where the hearing loss was smallest at 4 kHz and increased by at least 10 dB at adjacent frequencies.

[1]  J. H. Mills,et al.  A comparison of brainstem, whole-nerve AP and single-fiber tuning curves in the gerbil: Normative data , 1985, Hearing Research.

[2]  J. Mills,et al.  Recoveries of whole-nerve AP thresholds, amplitudes and tuning curves in gerbils following noise exposure , 1989, Hearing Research.

[3]  G. V. Simpson,et al.  Altered peripheral and brainstem auditory function in aged rats , 1985, Brain Research.

[4]  Willy Passchier-Vermeer The Effects of Age, Otological Factors and Occupational Noise Exposure on Hearing Threshold Levels of Various Populations , 1986 .

[5]  R. Pujol,et al.  Age-related changes in the C57BL/6J mouse cochlea. I. Physiological findings. , 1981, Brain research.

[6]  E. Ostapoff,et al.  A degenerative disorder of the central auditory system of the gerbil , 1989, Hearing Research.

[7]  B. Faddis,et al.  Auditory experience affects degeneration of the ventral cochlear nucleus in mongolian gerbils , 1987, Hearing Research.

[8]  J. Mills,et al.  Anesthesia effects: auditory brain-stem response. , 1989, Electroencephalography and clinical neurophysiology.

[9]  T. Bhattacharyya,et al.  Age-Related Cochlear Hair Cell Loss in the Chinchilla , 1985, The Annals of otology, rhinology, and laryngology.

[10]  William L. Baughn Relation between Daily Noise Exposure and Hearing Loss Based on the Evaluation of 6,835 Industrial Noise Exposure Cases , 1973 .

[11]  J. Buchwald,et al.  Auditory brainstem responses in the aged cat , 1982, Neurobiology of Aging.

[12]  M. Bergman,et al.  LXII Presbycusis Study of a Relatively Noise-Free Population in the Sudan , 1962, The Annals of otology, rhinology, and laryngology.

[13]  E. Keithley,et al.  Spiral ganglion cell density in young and old gerbils , 1989, Hearing Research.

[14]  J. Lindsay,et al.  Histopathological Observations of Presbycusis , 1976, The Annals of otology, rhinology, and laryngology.

[15]  R. Naunton,et al.  Human whole-nerve response to clicks of various frequency. , 1976, Audiology : official organ of the International Society of Audiology.

[16]  V. Schramm,et al.  Analysis of Age-Related Changes in Electric Responses from the Inner Ear of Rats , 1972, The Annals of otology, rhinology, and laryngology.

[17]  W. Burns,et al.  Hearing and noise in industry , 1970 .

[18]  Joe C. Adams,et al.  Immunolocalization of Na+, K+-ATPase and carbonic anhydrase in the gerbil's vestibular system , 1990, Hearing Research.

[19]  K R Henry,et al.  Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. , 1980, Audiology : official organ of the International Society of Audiology.

[20]  K. Henry Influence of genotype and age on noise-induced auditory losses , 1982, Behavior genetics.

[21]  K. Parham,et al.  Response properties of inferior colliculus neurons in young and very old CBA/J mice , 1988, Hearing Research.

[22]  Tapan K. Bhattacharyya,et al.  Influence of age on hair cell loss in the rabbit cochlea , 1989, Hearing Research.

[23]  J. Zwislocki Theory of Temporal Auditory Summation , 1960 .

[24]  A. J. Klein,et al.  Acoustically dependent latency shifts of BSER (wave V) in man. , 1978, The Journal of the Acoustical Society of America.

[25]  J. Willott,et al.  Morphometric study of the anteroventral cochlear nucleus of two mouse models of presbycusis , 1987, The Journal of comparative neurology.

[26]  D. Eldredge,et al.  Temporary threshold shifts in chinchilla: electrophysiological correlates. , 1972, The Journal of the Acoustical Society of America.

[27]  K. Henry,et al.  Disparity in the cytocochleogram and the electrocochleogram in aging LP/J and A/J inbred mice. , 1983, Audiology : official organ of the International Society of Audiology.

[28]  R. D. Bruce,et al.  Book Reviews : HEARING AND NOISE IN INDUSTRY W. Burns and D. W. Robinson Her Majesty's Stationery Office, London, England (1970) , 1976 .

[29]  J. F. Corso Age correction factor in noise-induced hearing loss: a quantitative model. , 1980, Audiology.

[30]  M. Feldman,et al.  Hair cell counts in an age-graded series of rat cochleas , 1982, Hearing Research.

[31]  M. Feldman,et al.  Spiral ganglion cell counts in an age‐graded series of rat cochleas , 1979, The Journal of comparative neurology.

[32]  Demonstration of presbycusis across repeated measures in a nonhuman primate species. , 1983, Behavioral neuroscience.

[33]  M. Møller Hearing in 70 and 75 year old people: results from a cross sectional and longitudinal population study. , 1981, American journal of otolaryngology.

[34]  J. Coleman Hair cell loss as a function of age in the normal cochlea of the guinea pig. , 1976, Acta oto-laryngologica.

[35]  H. Davis,et al.  Principles of electric response audiometry. , 1976, The Annals of otology, rhinology, and laryngology.

[36]  K. D. Kryter Presbycusis, sociocusis and nosocusis , 1983 .

[37]  M. Cheal The gerbil: a unique model for research on aging. , 1986, Experimental aging research.

[38]  W. Covell,et al.  Pathologic changes in the inner ears of senile guinea pigs , 1957, The Laryngoscope.

[39]  J. Willott Effects of aging, hearing loss, and anatomical location on thresholds of inferior colliculus neurons in C57BL/6 and CBA mice. , 1986, Journal of neurophysiology.

[40]  A. Ryan,et al.  Hearing sensitivity of the mongolian gerbil, Meriones unguiculatis. , 1976, The Journal of the Acoustical Society of America.

[41]  E. Mościcki,et al.  Hearing Loss in the Elderly: An Epidemiologic Study of the Framingham Heart Study Cohort , 1985, Ear and hearing.

[42]  J. E. Hawkins Comparative otopathology: aging, noise, and ototoxic drugs. , 1973, Advances in oto-rhino-laryngology.

[43]  R. A. Schmiedt Spontaneous rates, thresholds and tuning of auditory-nerve fibers in the gerbil: Comparisons to cat data , 1989, Hearing Research.

[44]  A. Spoor,et al.  Presbycusis Values in Relation to Noise Induced Hearing Loss , 1967 .

[45]  D. W. Robinson,et al.  Age effect in hearing - a comparative analysis of published threshold data. , 1979, Audiology : official organ of the International Society of Audiology.

[46]  R. A. Schmiedt,et al.  Brainstem, whole-nerve AP and single-fiber suppression in the gerbil: Normative data , 1985, Hearing Research.

[47]  R. Levine,et al.  Comparison of cat and human brain-stem auditory evoked potentials. , 1987, Electroencephalography and clinical neurophysiology.

[48]  J. Willott Changes in frequency representation in the auditory system of mice with age-related hearing impairment , 1984, Brain Research.

[49]  R. A. Schmiedt Acoustic distortion in the ear canal. I. Cubic difference tones: effects of acute noise injury. , 1986, The Journal of the Acoustical Society of America.

[50]  C. Devigne,et al.  Age-related changes in the C57BL/6J mouse cochlea. II. Ultrastructural findings. , 1981, Brain research.