Pressure-assisted spinning: A versatile and economical, direct fibre to scaffold spinning methodology

Spinning composite polymer fibres by means of electric fields has been investigated for well over a century. These spun fibres have been explored across many areas of research, spanning the physical to the life sciences; however, electrospinning has the hazardous nature of the high voltage at the spinning needle. We demonstrate here a competing direct fibre to scaffold preparation method, completely determined by an applied pressure. Our technique reported here removes the hazardous high-voltage element from the fibre/scaffold formation technique and has the ability to form uniaxial fibres and scaffolds comparable to those fabricated by electrospinning. We refer to this fibre generation approach as "pressure-assisted spinning (PAS)", which will have a tremendous impact in a range of applications, spanning the physical through to the life sciences. PAS joins the techniques for fibre to scaffold generation with a view to significantly and globally contributing to the micro- and nanosciences.

[1]  L. Larrondo,et al.  Electrostatic fiber spinning from polymer melts. II. Examination of the flow field in an electrically driven jet , 1981 .

[2]  Miqin Zhang,et al.  Electrospun chitosan-based nanofibers and their cellular compatibility. , 2005, Biomaterials.

[3]  L. Larrondo,et al.  Electrostatic fiber spinning from polymer melts. III. Electrostatic deformation of a pendant drop of polymer melt , 1981 .

[4]  C. Laurencin,et al.  Development of novel tissue engineering scaffolds via electrospinning , 2004, Expert opinion on biological therapy.

[5]  S. Jayasinghe.  Self-assembled nanostructures via electrospraying , 2006 .

[6]  A. Gañán-Calvo,et al.  Low and high Reynolds number flows inside Taylor cones , 1998 .

[7]  G. Whitesides,et al.  Self-Assembly at All Scales , 2002, Science.

[8]  C. Sung,et al.  Nanocharacterization of Electrospun Nanofibers of Polyaniline/Poly Methyl Methacrylate Blends Using SEM, TEM and AFM , 2004, Microscopy and Microanalysis.

[9]  Younan Xia,et al.  Use of electrospinning to directly fabricate hollow nanofibers with functionalized inner and outer surfaces. , 2004, Small.

[10]  M. Márquez,et al.  Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets , 2002, Science.

[11]  J. Mead,et al.  Preparation of Core‐Sheath Nanofibers from Conducting Polymer Blends , 2005 .

[12]  Yen Wei,et al.  Preparation and Characterization of Polypyrrole/TiO2 Coaxial Nanocables , 2006 .

[13]  D. Reneker,et al.  Nanometre diameter fibres of polymer, produced by electrospinning , 1996 .

[14]  J. Deitzel,et al.  The effect of processing variables on the morphology of electrospun nanofibers and textiles , 2001 .

[15]  Suwan N Jayasinghe,et al.  Electrohydrodynamic jet processing: an advanced electric-field-driven jetting phenomenon for processing living cells. , 2006, Small.

[16]  Zhi‐Kang Xu,et al.  Nanofibrous Membranes Containing Carbon Nanotubes: Electrospun for Redox Enzyme Immobilization , 2006 .

[17]  J. Rosell-Llompart,et al.  Generation of monodisperse droplets 0.3 to 4 μm in diameter from electrified cone-jets of highly conducting and viscous liquids , 1994 .

[18]  K. Leong,et al.  Significance of synthetic nanostructures in dictating cellular response. , 2005, Nanomedicine : nanotechnology, biology, and medicine.

[19]  Yi Xin,et al.  Fabrication of highly photoluminescent TiO2/PPV hybrid nanoparticle-polymer fibers by electrospinning , 2007 .

[20]  Kam W Leong,et al.  Sustained release of proteins from electrospun biodegradable fibers. , 2005, Biomacromolecules.

[21]  D. J. Brunner,et al.  ELECTROHYDRODYNAMIC ATOMIZATION IN THE CONE–JET MODE PHYSICAL MODELING OF THE LIQUID CONE AND JET , 1997 .

[22]  M. Mann,et al.  Electrospray ionization for mass spectrometry of large biomolecules. , 1989, Science.

[23]  S. Jayasinghe,et al.  Electrospraying: an in-situ polymerisation route for fabricating high macroporous scaffolds , 2006 .

[24]  W. Park,et al.  Preparation of Polymer Nanofibers Containing Silver Nanoparticles by Using Poly(N-vinylpyrrolidone) , 2005 .

[25]  Anthony S Weiss,et al.  Electrospun protein fibers as matrices for tissue engineering. , 2005, Biomaterials.

[26]  Suwan N Jayasinghe,et al.  Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. , 2006, Biomacromolecules.

[27]  S. Jayasinghe.  A Novel Technique for Forming Self‐Assembled Nanotube Structures , 2006 .

[28]  S. Ramakrishna,et al.  A review on electrospinning design and nanofibre assemblies , 2006, Nanotechnology.

[29]  Ioannis S. Chronakis,et al.  Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process—A review , 2005 .

[30]  Seong H. Kim,et al.  Fabrication of Electrically Conducting Polypyrrole‐Poly(ethylene oxide) Composite Nanofibers , 2005 .

[31]  I. Hayati,et al.  Mechanism of stable jet formation in electrohydrodynamic atomization , 1986, Nature.

[32]  Suwan N Jayasinghe,et al.  Electric field driven jetting: an emerging approach for processing living cells , 2006, Biotechnology journal.

[33]  Michael P. Brenner,et al.  Electrospinning: A whipping fluid jet generates submicron polymer fibers , 2001 .

[34]  L. Larrondo,et al.  Electrostatic fiber spinning from polymer melts. I. Experimental observations on fiber formation and properties , 1981 .